Roles of RNA modifications in aging and age-related diseases

RNA modifications are key epigenetic alterations that play regulatory functions in RNA biology, including RNA stability and translation. Emerging evidence indicates that RNA modification is crucial for various physiological and pathological processes, including aging. This review describes functions...

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Published in:BMB reports Vol. 58; no. 9; pp. 389 - 396
Main Authors: Eunseok Kang, Rosa Haque, Hanseul Lee, Seung-jae V. Lee
Format: Journal Article
Language:Korean
Published: 생화학분자생물학회 30.09.2025
Subjects:
Age-related diseases
Aging
Longevity
RNA modification
Senescence
Aging
RNA modification
Senescence
Age-related diseases
Longevity
ISSN:1976-6696, 1976-670X
Online Access:Get full text
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Summary:RNA modifications are key epigenetic alterations that play regulatory functions in RNA biology, including RNA stability and translation. Emerging evidence indicates that RNA modification is crucial for various physiological and pathological processes, including aging. This review describes functions of key RNA modifications, including N 6 -methyladenosine (m 6 A), 5-methylcytosine (m 5 C), N 7 -methylguanosine (m 7 G), 2’-O-methylation (Nm), N 1 -methyladenosine (m 1 A), adenosine-to-inosine (A-to-I) RNA editing, pseudouridylation (ψ), and N4-acetylcytidine (ac4C), highlighting their roles in aging and age-associated diseases. We also discuss dynamics of RNA modifications and associated protein factors during aging. This review provides important information on molecular mechanisms underlying aging regulation, focusing on effects of RNA modifications, which can help us understand healthy longevity in humans. [BMB Reports 2025; 58(9): 389-396]
Bibliography:Korean Society for Biochemistry and Molecular Biology
KISTI1.1003/JNL.JAKO202530350455864
ISSN:1976-6696
1976-670X
DOI:10.5483/BMBRep.2025-0053