NEAT1: A novel cancer‐related long non‐coding RNA

Aberrant overexpression of the long non‐coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor pro...

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Vydané v:Cell proliferation Ročník 50; číslo 2; s. np - n/a
Hlavní autori: Yu, Xin, Li, Zheng, Zheng, Heyi, Chan, Matthew T. V., Wu, William Ka Kei
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England John Wiley & Sons, Inc 01.04.2017
John Wiley and Sons Inc
Predmet:
Aberration
Animals
Cancer
Carcinogenesis - genetics
Carcinoma, Hepatocellular - genetics
Cell Line, Tumor
Colorectal carcinoma
Colorectal Neoplasms - genetics
Differentiation
Esophagus
Hepatocellular carcinoma
Humans
Leukemia
Liver Neoplasms - genetics
Lung cancer
Non-coding RNA
Review
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
Transcription
Tumors
Utilities
ISSN:0960-7722, 1365-2184
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Popis
Shrnutí:Aberrant overexpression of the long non‐coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast, NEAT1 is downregulated in acute promyelocytic leukaemia where it promotes leucocyte differentiation. In this review, we provide an overview of current evidence concerning the oncogenic role and potential clinical utilities of NEAT1. Further investigations are warranted to elucidate the upstream and downstream mechanisms of NEAT1 overexpression.
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ObjectType-Review-1
ISSN:0960-7722
1365-2184
DOI:10.1111/cpr.12329