Monocyte heterogeneity and functions in cancer

Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diver...

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Bibliographic Details
Published in:Journal of leukocyte biology Vol. 106; no. 2; pp. 309 - 322
Main Authors: Olingy, Claire E., Dinh, Huy Q., Hedrick, Catherine C.
Format: Journal Article
Language:English
Published: England Oxford University Press 01.08.2019
John Wiley and Sons Inc
Subjects:
Angiogenesis
Animals
Biomarkers
Cancer
Cancer therapies
Cell Movement
Combined Modality Therapy
Dendritic cells
Disease Management
Disease Susceptibility
Extracellular matrix
Heterogeneity
Homeostasis
Humans
Immune clearance
Immune system
Immunophenotyping
Lymphocytes
Macrophages
Monocytes
Monocytes - immunology
Monocytes - metabolism
Monocytes - pathology
Mononuclear phagocyte system
myeloid cells
Neoplasms - diagnosis
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - therapy
Phagocytosis
Review
Reviews
tumor microenvironment
Tumor Microenvironment - immunology
Tumors
Monocytes
cancer
myeloid cells
tumor microenvironment
ISSN:0741-5400, 1938-3673, 1938-3673
Online Access:Get full text
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Summary:Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functions that contribute to both pro‐ and antitumoral immunity, including phagocytosis, secretion of tumoricidal mediators, promotion of angiogenesis, remodeling of the extracellular matrix, recruitment of lymphocytes, and differentiation into tumor‐associated macrophages and dendritic cells. The ability of cancer to evade immune recognition and clearance requires protumoral signals to outweigh ongoing attempts by the host immune system to prevent tumor growth. This review discusses current understanding of monocyte heterogeneity during homeostasis, highlights monocyte functions in cancer progression, and describes monocyte‐targeted therapeutic strategies for cancer treatment. Review on monocyte heterogeneity, monocyte roles in cancer progression, and therapeutic strategies to target monocytes for cancer treatment.
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ISSN:0741-5400
1938-3673
1938-3673
DOI:10.1002/JLB.4RI0818-311R