Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

Aims/hypothesis The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium...

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Vydané v:Diabetologia Ročník 60; číslo 6; s. 1022 - 1032
Hlavní autori: Chen, Yu, Wu, Fen, Saito, Eiko, Lin, Yingsong, Song, Minkyo, Luu, Hung N., Gupta, Prakash C., Sawada, Norie, Tamakoshi, Akiko, Shu, Xiao-Ou, Koh, Woon-Puay, Xiang, Yong-Bing, Tomata, Yasutake, Sugiyama, Kemmyo, Park, Sue K., Matsuo, Keitaro, Nagata, Chisato, Sugawara, Yumi, Qiao, You-Lin, You, San-Lin, Wang, Renwei, Shin, Myung-Hee, Pan, Wen-Harn, Pednekar, Mangesh S., Tsugane, Shoichiro, Cai, Hui, Yuan, Jian-Min, Gao, Yu-Tang, Tsuji, Ichiro, Kanemura, Seiki, Ito, Hidemi, Wada, Keiko, Ahn, Yoon-Ok, Yoo, Keun-Young, Ahsan, Habibul, Chia, Kee Seng, Boffetta, Paolo, Zheng, Wei, Inoue, Manami, Kang, Daehee, Potter, John D.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2017
Springer Nature B.V
Predmet:
Aged
Asia
Bile ducts
Cancer
Cervix
Colon
Consortia
Death
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - mortality
Diabetes Mellitus, Type 2 - physiopathology
Endometrium
Esophagus
Exercise
Female
Gallbladder
Health risk assessment
Human Physiology
Humans
Hypertension - mortality
Hypertension - physiopathology
Internal Medicine
Kidneys
Leukemia
Liver
Lungs
Lymphoma
Male
Medicine
Medicine & Public Health
Meta-analysis
Metabolic Diseases
Middle Aged
Mortality
Neoplasms - mortality
Neoplasms - physiopathology
Pancreas
Prostate
Randomized Controlled Trials as Topic
Rectum
Stomach
Surveys and Questionnaires
Thyroid
Thyroid gland
Urinary bladder
Type 2 diabetes
Cancer mortality
Asia Cohort Consortium
Asians
Meta-analysis
ISSN:0012-186X, 1432-0428, 1432-0428
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Shrnutí:Aims/hypothesis The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. Results During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Significant positive associations with diabetes were observed for cancers of the colorectum (HR 1.41; 95% CI 1.26, 1.57), liver (HR 2.05; 95% CI 1.77, 2.38), bile duct (HR 1.41; 95% CI 1.04, 1.92), gallbladder (HR 1.33; 95% CI 1.10, 1.61), pancreas (HR 1.53; 95% CI 1.32, 1.77), breast (HR 1.72; 95% CI 1.34, 2.19), endometrium (HR 2.73; 95% CI 1.53, 4.85), ovary (HR 1.60; 95% CI 1.06, 2.42), prostate (HR 1.41; 95% CI 1.09, 1.82), kidney (HR 1.84; 95% CI 1.28, 2.64) and thyroid (HR 1.99; 95% CI 1.03, 3.86), as well as lymphoma (HR 1.39; 95% CI 1.04, 1.86). Diabetes was not statistically significantly associated with the risk of death from leukaemia and cancers of the bladder, cervix, oesophagus, stomach and lung. Conclusions/interpretation Diabetes was associated with a 26% increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.
Bibliografia:ObjectType-Article-1
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ISSN:0012-186X
1432-0428
1432-0428
DOI:10.1007/s00125-017-4229-z