The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults

The aim of this study was to assess the Dutch nationwide incidence of myelin oligodendrocyte glycoprotein (MOG)-IgG-associated acquired demyelinating syndromes (ADS) and to describe the clinical and serological characteristics of these patients. All serum samples for routine diagnostics from Februar...

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Veröffentlicht in:Multiple sclerosis Jg. 26; H. 7; S. 1352458519845112
Hauptverfasser: de Mol, C L, Wong, Yym, van Pelt, E D, Wokke, Bha, Siepman, Tam, Neuteboom, R F, Hamann, D, Hintzen, R Q
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.06.2020
Schlagworte:
multiple sclerosis variants
Acquired demyelinating syndromes
anti-MOG antibodies
children
incidence
adults
ISSN:1477-0970, 1477-0970
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Zusammenfassung:The aim of this study was to assess the Dutch nationwide incidence of myelin oligodendrocyte glycoprotein (MOG)-IgG-associated acquired demyelinating syndromes (ADS) and to describe the clinical and serological characteristics of these patients. All serum samples for routine diagnostics from February 2014 to December 2017 were sent to the single central reference laboratory for the full-length MOG-IgG cell-based assay (CBA) in the Netherlands. Clinical data from patients known in our National ADS centre were available. A total of 1414 samples of 1277 patients were received; of these, 92 patients (7%) were MOG-IgG-seropositive. The mean incidence was 0.16/100,000 people, with higher seropositivity in children (0.31/100,000) than in adults (0.13/100,000). In MOG-IgG-positive patients at the National ADS centre (61/92, 66%), the most common presenting phenotype is acute disseminated encephalomyelitis (ADEM, 56%) in children and optic neuritis (ON, 44%) in adults. Relapsing disease occurred in 9/34 (26%) children and 11/27 (41%) adults during median follow-up of 27.5 months. Patients were tested MOG-IgG-positive >200 months after the initial attack, suggesting an extended time to first relapse (TTFR). Longitudinal analysis of MOG-IgG (25/61, 41%) showed that 67% of the monophasic patients remain seropositive and 60% in relapsing patients. Majority of seronegative patients had no relapses (89%). This nationwide study shows that the overall incidence of MOG-IgG-seropositive disorders is 0.16 per 100,000 people. The distribution over the clinical phenotypes differs between adults and children. Seropositivity can be maintained over years even without clinical activity, while seronegative patients generally had no relapses.
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ISSN:1477-0970
1477-0970
DOI:10.1177/1352458519845112