Lymphatic distribution of an anti-tumor agent in postoperative adjuvant chemotherapy in gastric cancer: fat-emulsified preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil in lymph

In 8 postoperative patients with gastric cancer the effectiveness of fat emulsification of tegafur as a means of improving the drug distribution in the lymphatic tissue was studied. A water-in-oil type of emulsion of tegafur (FT-w/o) and an oil-in-water type of emulsion of tegafur (FT-o/w) were oral...

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Veröffentlicht in:Japanese journal of cancer research (Gann) Jg. 76; H. 12; S. 1230
Hauptverfasser: Hanaue, H, Kurosawa, T, Miyakawa, S, Horie, F, Nemoto, A, Nishimura, S, Yamoto, H, Yasuda, H, Asagoe, T, Miura, S
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Japan 1985
Schlagworte:
Administration, Oral
Adult
Combined Modality Therapy
Emulsions
Humans
Lymph - metabolism
Lymphoid Tissue - metabolism
Male
Middle Aged
Stomach Neoplasms - drug therapy
Stomach Neoplasms - surgery
Tegafur - administration & dosage
Time Factors
Tissue Distribution
ISSN:0910-5050
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Zusammenfassung:In 8 postoperative patients with gastric cancer the effectiveness of fat emulsification of tegafur as a means of improving the drug distribution in the lymphatic tissue was studied. A water-in-oil type of emulsion of tegafur (FT-w/o) and an oil-in-water type of emulsion of tegafur (FT-o/w) were orally administered. A fistula in the thoracic duct, prepared in advance, was used to collect lymph. The concentrations of tegafur and 5-FU were compared in simultaneously obtained specimens of lymph and peripheral blood. In the case of FT-w/o, the tegafur concentration at 30-60 min after administration was significantly higher in both the lymph and plasma than that found using FT-o/w. In the case of FT-w/o, the 5-FU concentration at 30-120 min after the administration was significantly higher than that found with FT-o/w in both the lymph and the plasma. Thus, FT-w/o shows excellent distribution in both lymph and blood, and is considered useful as an adjuvant chemotherapeutic agent in the postoperative treatment of gastric cancer patients.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0910-5050
DOI:10.20772/cancersci1985.76.12_1230