MRGPRX2 is negatively targeted by SCF and IL‐4 to diminish pseudo‐allergic stimulation of skin mast cells in culture

MRGPRX2 was recently uncovered as the “missing link” in clinically relevant mast cell (MC) activation explaining previously puzzling phenomena. It is the receptor for various endogenous ligands and exogenous compounds alike, whose binding evokes rapid degranulation much like allergen‐mediated exocyt...

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Bibliographic Details
Published in:	Experimental dermatology Vol. 27; no. 11; pp. 1298 - 1303
Main Authors:	Babina, Magda, Wang, Zhao, Artuc, Metin, Guhl, Sven, Zuberbier, Torsten
Format:	Journal Article
Language:	English
Published:	Denmark Wiley Subscription Services, Inc 01.11.2018
Subjects:	Allergens allergy Cell activation Cell culture Degranulation Exocytosis Hypersensitivity Mast cells MRGPRX2 pseudo‐allergy SCF Skin allergy pseudo-allergy mast cells MRGPRX2 SCF
ISSN:	0906-6705, 1600-0625, 1600-0625
Online Access:	Get full text
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