The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on 86Rb efflux in rat blood vessels

The effects of the antihypertensive agent BRL 34915 on a variety of responses of the aorta and portal vein of the rat have been compared with those of nicorandil. On portal vein, BRL 34915 (0.01-50 X 10(-6) M) and nicorandil (0.1-500 X 10(-6) M) abolished spontaneous mechanical activity and reduced...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 88; no. 1; p. 121
Main Authors:	Weir, S W, Weston, A H
Format:	Journal Article
Language:	English
Published:	England 01.05.1986
Subjects:	Animals Antihypertensive Agents - pharmacology Aorta, Thoracic - drug effects Benzopyrans - pharmacology Cromakalim In Vitro Techniques Ion Channels - drug effects Male Membrane Potentials - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Nicorandil Norepinephrine - pharmacology Portal Vein - drug effects Pyrroles - pharmacology Radioisotopes Rats Rats, Inbred Strains Rubidium Time Factors
ISSN:	0007-1188
Online Access:	Get more information
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