Amyloid-like p53 as prognostic biomarker in serous ovarian cancer—a study of the OVCAD consortium

TP53 is the most commonly mutated gene in cancer and has been shown to form amyloid-like aggregates, similar to key proteins in neurodegenerative diseases. Nonetheless, the clinical implications of p53 aggregation remain unclear. Here, we investigated the presence and clinical relevance of p53 aggre...

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Veröffentlicht in:	Oncogene Jg. 42; H. 33; S. 2473 - 2484
Hauptverfasser:	Heinzl, Nicole, Maritschnegg, Elisabeth, Koziel, Katarzyna, Schilhart-Wallisch, Christine, Heinze, Georg, Yang, Wei-Lei, Bast, Robert C., Sehouli, Jalid, Braicu, Elena I., Vergote, Ignace, Van Gorp, Toon, Mahner, Sven, Paspalj, Valentina, Grimm, Christoph, Obermayr, Eva, Schuster, Eva, Holzer, Barbara, Rousseau, Frederic, Schymkowitz, Joost, Concin, Nicole, Zeillinger, Robert
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 11.08.2023 Nature Publishing Group
Schlagworte:	13/1 13/2 13/51 14 14/63 45/29 631/67/1517/1709 692/53/2422 82 Amyloid Apoptosis Autoantibodies Cell Biology Cytotoxicity Human Genetics Immune response Internal Medicine Medical prognosis Medicine Medicine & Public Health Missense mutation Neurodegenerative diseases Oncology Ovarian cancer p53 Protein Survival
ISSN:	0950-9232, 1476-5594, 1476-5594
Online-Zugang:	Volltext
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