Bacterial evasion of antimicrobial peptides by biofilm formation

Biofilm formation is a main virulence determinant in many bacterial infections. It significantly increases bacterial resistance to antibiotics and innate host defense. In general, the specific physiology of biofilms and the barrier function of the extracellular biofilm matrix determine resistance to...

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Vydáno v:Current topics in microbiology and immunology Ročník 306; s. 251
Hlavní autor: Otto, M
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany 2006
Témata:
Adhesins, Bacterial - physiology
Animals
Antimicrobial Cationic Peptides - physiology
Bacterial Capsules - physiology
Bacterial Infections - immunology
Biofilms - growth & development
Drug Resistance, Bacterial
Humans
Polysaccharides, Bacterial - physiology
ISSN:0070-217X
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Shrnutí:Biofilm formation is a main virulence determinant in many bacterial infections. It significantly increases bacterial resistance to antibiotics and innate host defense. In general, the specific physiology of biofilms and the barrier function of the extracellular biofilm matrix determine resistance to antibacterials. However, resistance to antimicrobial peptides appears to be mainly based on the interaction with biofilm and capsule exopolymers. These polymers may work by electrostatic repulsion and/or sequestration of antibacterial substances. As biofilm polymers play an eminent role in biofilm structuring and resistance, their destruction by dedicated enzymes is a promising attempt to prevent colonization and develop treatment for biofilm-associated infections.
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ISSN:0070-217X
DOI:10.1007/3-540-29916-5_10