Ebola virus entry requires the host-programmed recognition of an intracellular receptor

Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite considerable efforts, no essential cellular receptors for filovirus entry have been identified. We showed previously that Niemann‐Pick C1 (NPC1), a lysosomal cholesterol transporter, is required for filovirus entry....

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Veröffentlicht in:	The EMBO journal Jg. 31; H. 8; S. 1947 - 1960
Hauptverfasser:	Miller, Emily Happy, Obernosterer, Gregor, Raaben, Matthijs, Herbert, Andrew S, Deffieu, Maika S, Krishnan, Anuja, Ndungo, Esther, Sandesara, Rohini G, Carette, Jan E, Kuehne, Ana I, Ruthel, Gordon, Pfeffer, Suzanne R, Dye, John M, Whelan, Sean P, Brummelkamp, Thijn R, Chandran, Kartik
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Chichester, UK John Wiley & Sons, Ltd 18.04.2012 Nature Publishing Group UK Springer Nature B.V Nature Publishing Group
Schlagworte:	Animals Binding sites Carrier Proteins - metabolism Cell Line Cholesterol Ebola virus Ebolavirus - physiology EMBO20 EMBO23 Filovirus Glycoproteins Humans Marburg virus Membrane Glycoproteins - metabolism Membranes Microbiology Models, Biological Models, Molecular Molecular biology Niemann-Pick C1 Outbreaks Protein Binding Receptors, Virus - metabolism Viperidae viral entry Viral Envelope Proteins - chemistry Viral Envelope Proteins - metabolism viral receptor Virus Internalization Ebola virus viral entry Marburg virus Niemann‐Pick C1 viral receptor
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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