Age-Varying Association Between Statin Use and Incident Alzheimer's Disease

OBJECTIVES: To determine whether risk reduction of statins for Alzheimer's disease (AD) varies by age or presence of apolipoprotein E (APOE) ɛ4 allele. DESIGN: A cohort of cognitively intact elderly participants was assessed biennially for dementia and AD. SETTING: Community based. PARTICIPANTS...

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Vydané v:	Journal of the American Geriatrics Society (JAGS) Ročník 58; číslo 7; s. 1311 - 1317
Hlavní autori:	Li, Ge, Shofer, Jane B., Rhew, Isaac C., Kukull, Walter A., Peskind, Elaine R., McCormick, Wayne, Bowen, James D., Schellenberg, Gerard D., Crane, Paul K., Breitner, John C.S., Larson, Eric B.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Malden, USA Blackwell Publishing Inc 01.07.2010 Wiley-Blackwell
Predmet:	Adult and adolescent clinical studies Age Factors Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer Disease - prevention & control Alzheimer's disease APOE genotype Apolipoprotein E4 - genetics Biological and medical sciences Cohort Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female General aspects Genotype Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Incidence Male Medical sciences Neurology old age Organic mental disorders. Neuropsychology Proportional Hazards Models Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors statin Human Nervous system diseases Typing Alzheimer disease Use Genotype Statin derivative Cerebral disorder Gerontology Association statin Apolipoprotein E old age Central nervous system disease Degenerative disease Elderly Alzheimer's disease Age Geriatrics Antilipemic agent APOE genotype
ISSN:	0002-8614, 1532-5415, 1532-5415
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