Drug resistance and IS6110-RFLP patterns of Mycobacterium tuberculosis in patients with recurrent tuberculosis in northern Thailand

The emergence of drug resistant Mycobacterium tuberculosis has become a global threat to tuberculosis (TB) prevention and control efforts. This study aimed to determine the drug resistance profiles and DNA fingerprints of M. tuberculosis strains isolated from patients with relapsed or retreatment pu...

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Vydané v:Microbiology and immunology Ročník 57; číslo 1; s. 21 - 29
Hlavní autori: Sukkasem, Supaporn, Yanai, Hideki, Mahasirimongkol, Surakameth, Yamada, Norio, Rienthong, Dhanida, Palittapongarnpim, Prasit, Khusmith, Srisin
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Australia Blackwell Publishing Ltd 01.01.2013
Wiley Subscription Services, Inc
Predmet:
Adult
Aged
Antitubercular Agents - pharmacology
DNA Fingerprinting
DNA Transposable Elements
Drug resistance
Drug Resistance, Bacterial
Female
Genotype
Humans
IS6110- restriction fragment length polymorphism patterns
Male
Middle Aged
Molecular Typing
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Polymorphism, Restriction Fragment Length
Recurrence
recurrent tuberculosis
Thailand
Tuberculosis
Tuberculosis, Pulmonary - microbiology
Thailand
ISSN:0385-5600, 1348-0421, 1348-0421
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Shrnutí:The emergence of drug resistant Mycobacterium tuberculosis has become a global threat to tuberculosis (TB) prevention and control efforts. This study aimed to determine the drug resistance profiles and DNA fingerprints of M. tuberculosis strains isolated from patients with relapsed or retreatment pulmonary TB in Chiang Rai province in northern Thailand. Significant differences in multidrug resistance (MDR) (P = 0.025) and resistance to isoniazid (P = 0.025) and rifampin (P = 0.046) between first and second registrations of patients with retreatment TB were found. However, there were no significant differences in resistance to any drugs in patients with relapsed TB. The rate of MDR‐TB strains was 12.2% among new patients at first registration, 22.5% among patients with recurrence who had previously undergone treatment at second registration and 12.5% at third registration. Two retreatment patients whose initial treatment had failed had developed MDR‐TB with resistance to all TB drugs tested, including rifampin, isoniazid, streptomycin and ethambutol. IS6110‐RFLP analysis revealed that 66.7% (10/15 isolates) of MDR‐TB belonged to the Beijing family. In most cases, IS6110‐RFLP patterns of isolates from the same patients were identical in relapse and retreatment groups. However, some pairs of isolates from retreatment patients after treatment failure had non‐identical IS6110‐RFLP patterns. These results suggest that, after failure and default treatment, patients with retreatment tuberculosis have a significantly greater risk of MDR‐TB, isoniazid and rifampin resistance than do other patients.
Bibliografia:ark:/67375/WNG-JHZF44QR-1
ArticleID:MIM12000
istex:B7CBEF168B4EF658A317379C062341B40EEF4A06
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0385-5600
1348-0421
1348-0421
DOI:10.1111/1348-0421.12000