ACUTE EXPOSURE TO ARSENITE INDUCES METALLOTHIONEIN ISOFORM-SPECIFIC GENE EXPRESSION IN HUMAN PROXIMAL TUBULE CELLS

The expression of metallothionein (MT) mRNA and protein was determined in human proximal tubule cells (HPT) following acute exposure to the classic stimulators of the stress response, heat and sodium arsenite (As 3+ ). Treatment of the cells with 100 µ M As 3+ for 4 h resulted in a significant incre...

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Bibliographic Details

Published in:	Journal of Toxicology and Environmental Health, Part A Vol. 64; no. 4; pp. 343 - 355
Main Authors:	Garrett, Scott H., Belcastro, Marycharmain, Sens, Mary Ann, Somji, Seema, Sens, Donald A.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 26.10.2001
Subjects:	Arsenites - toxicity Cell Culture Techniques Enzyme Induction Gene Expression Regulation - drug effects Humans Isoenzymes Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Metallothionein - biosynthesis RNA, Messenger - biosynthesis Teratogens - toxicity
ISSN:	1528-7394, 1087-2620
Online Access:	Get full text
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