Metabolism and biomarkers of Vitamin D

Abstract The last decade has witnessed a renaissance in the interest in the metabolism and biological actions of vitamin D3. Part of this new found interest stems from the discovery that its active form, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], through its nuclear vitamin D receptor [VDR], regulates...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Scandinavian journal of clinical & laboratory investigation. Supplement Ročník 72; číslo S243; s. 7 - 13
Hlavný autor:	Jones, Glenville
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Colchester Informa Healthcare 01.04.2012 Taylor & Francis Informa
Predmet:	1,25-dihydroxyvitamin D3 25-hydroxyvitamin D Biological and medical sciences Biomarkers - blood Calcitriol - pharmacology Calcium homeostasis CYP24A1 CYP27B1 CYP2R1 DBP Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences phosphate homeostasis VDR Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - metabolism Vitamin D Deficiency - etiology Phosphates phosphate homeostasis 1,25-dihydroxyvitamin D3 Calcium 25-hydroxyvitamin D Steroid hormone VDR Calcitriol Homeostasis Biological marker Metabolism Inorganic element CYP27B1 CYP24A1 DBP Vitamin D Clinical biology Cholecalciferol(25-hydroxy) CYP2R1 Calcium homeostasis
ISSN:	0036-5513, 2166-1030, 1502-7686, 2166-1030
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Abstract The last decade has witnessed a renaissance in the interest in the metabolism and biological actions of vitamin D3. Part of this new found interest stems from the discovery that its active form, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], through its nuclear vitamin D receptor [VDR], regulates hundreds of genes around the body including those coding for proteins involved in cell differentiation and cell proliferation as well as calcium and phosphate homeostasis. Furthermore, epidemiological association studies have suggested that levels of the main circulating form, 25-hydroxyvitamin D3 [25(OH)D3] correlate positively with various health outcomes connected to major diseases: cancer, immune function and infections and cardiovascular disease. Consequently, the biochemistry around the metabolism of vitamin D, its mechanism of its action in target cells and the clinical chemistry questions regarding its specific and sensitive assay remain relevant. This short article will review the current state of knowledge of the cytochrome P450-enzymes involved in activation and inactivation of vitamin D, as well as provide a synopsis of the biochemistry and physiology surrounding its roles in the body. The review will end by discussing the appropriate biomarkers to assess vitamin D metabolism and vitamin D status in various clinical disease settings.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0036-5513 2166-1030 1502-7686 2166-1030
DOI:	10.3109/00365513.2012.681892