N-Substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.

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Podrobná bibliografie
Vydáno v:	Pharmazie Ročník 62; číslo 8; s. 636 - 637
Hlavní autoři:	Rakowitz, D., Gmeiner, A., Matuszczak, B.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	ESCHBORN Govi-Verlag Pharmazeutischer Verlag Gmbh 01.08.2007
Témata:	Acetates - chemical synthesis Acetates - pharmacology Aldehyde Reductase - antagonists & inhibitors Animals Cattle Chemistry Chemistry, Medicinal Chemistry, Multidisciplinary Dimethyl Sulfoxide Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Lens, Crystalline - enzymology Life Sciences & Biomedicine Magnetic Resonance Spectroscopy Pharmacology & Pharmacy Physical Sciences Quinazolines - chemical synthesis Quinazolines - pharmacology Science & Technology Solvents Spectrometry, Mass, Electrospray Ionization DIABETIC COMPLICATIONS POTENTIAL AGENTS
ISSN:	0031-7144
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Popis
Shrnutí:	Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
ISSN:	0031-7144
DOI:	10.1691/ph.2007.8.7520