N-Substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.

Saved in:
Bibliographic Details
Published in:Pharmazie Vol. 62; no. 8; pp. 636 - 637
Main Authors: Rakowitz, D., Gmeiner, A., Matuszczak, B.
Format: Journal Article
Language:English
Published: ESCHBORN Govi-Verlag Pharmazeutischer Verlag Gmbh 01.08.2007
Subjects:
Acetates - chemical synthesis
Acetates - pharmacology
Aldehyde Reductase - antagonists & inhibitors
Animals
Cattle
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Dimethyl Sulfoxide
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Lens, Crystalline - enzymology
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Pharmacology & Pharmacy
Physical Sciences
Quinazolines - chemical synthesis
Quinazolines - pharmacology
Science & Technology
Solvents
Spectrometry, Mass, Electrospray Ionization
DIABETIC COMPLICATIONS
POTENTIAL AGENTS
ISSN:0031-7144
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
ISSN:0031-7144
DOI:10.1691/ph.2007.8.7520