N-Substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.

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Veröffentlicht in:Pharmazie Jg. 62; H. 8; S. 636 - 637
Hauptverfasser: Rakowitz, D., Gmeiner, A., Matuszczak, B.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: ESCHBORN Govi-Verlag Pharmazeutischer Verlag Gmbh 01.08.2007
Schlagworte:
Acetates - chemical synthesis
Acetates - pharmacology
Aldehyde Reductase - antagonists & inhibitors
Animals
Cattle
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Dimethyl Sulfoxide
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Lens, Crystalline - enzymology
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Pharmacology & Pharmacy
Physical Sciences
Quinazolines - chemical synthesis
Quinazolines - pharmacology
Science & Technology
Solvents
Spectrometry, Mass, Electrospray Ionization
DIABETIC COMPLICATIONS
POTENTIAL AGENTS
ISSN:0031-7144
Online-Zugang:Weitere Angaben
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Beschreibung
Zusammenfassung:Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
ISSN:0031-7144
DOI:10.1691/ph.2007.8.7520