Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells

Here, we investigate the role of caveolin-1 (Cav-1) in breast cancer onset and progression, with a focus on epithelial-stromal interactions, ie, the tumor microenvironment. Cav-1 is highly expressed in adipocytes and is abundant in mammary fat pads (stroma), but it remains unknown whether loss of Ca...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 169; no. 5; p. 1784
Main Authors:	Williams, Terence M, Sotgia, Federica, Lee, Hyangkyu, Hassan, Ghada, Di Vizio, Dolores, Bonuccelli, Gloria, Capozza, Franco, Mercier, Isabelle, Rui, Hallgeir, Pestell, Richard G, Lisanti, Michael P
Format:	Journal Article
Language:	English
Published:	United States 01.11.2006
Subjects:	Adipose Tissue - cytology Adipose Tissue - pathology Animals Caveolin 1 - deficiency Caveolin 1 - metabolism Cell Proliferation Cyclin D1 - antagonists & inhibitors Cyclin D1 - metabolism Enzyme Activation Epithelial Cells - cytology Female Hyperplasia Male Mammary Glands, Animal - pathology Mammary Neoplasms, Animal - chemically induced Mammary Neoplasms, Animal - pathology Mammary Tumor Virus, Mouse Mice Mice, Knockout Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Phenotype Protective Agents - metabolism Signal Transduction STAT5 Transcription Factor - metabolism Stromal Cells - cytology
ISSN:	0002-9440
Online Access:	Get more information
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