Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases

Spontaneous beating of rabbit sinoatrial node cells (SANCs) is controlled by cAMP-mediated, protein kinase A-dependent local subsarcolemmal ryanodine receptor Ca(2+) releases (LCRs). LCRs activated an inward Na(+)/Ca(2+) exchange current that increases the terminal diastolic depolarization rate and,...

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Bibliographic Details
Published in:	Circulation research Vol. 102; no. 7; p. 761
Main Authors:	Vinogradova, Tatiana M, Sirenko, Syevda, Lyashkov, Alexey E, Younes, Antoine, Li, Yue, Zhu, Weizhong, Yang, Dongmei, Ruknudin, Abdul M, Spurgeon, Harold, Lakatta, Edward G
Format:	Journal Article
Language:	English
Published:	United States 11.04.2008
Subjects:	1-Methyl-3-isobutylxanthine - pharmacology Animals Biological Clocks - physiology Calcium - metabolism Calcium-Binding Proteins - metabolism Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Activation Heart Rate - physiology Patch-Clamp Techniques Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases - drug effects Phosphoric Diester Hydrolases - metabolism Phosphorylation Rabbits Ryanodine Receptor Calcium Release Channel - metabolism Signal Transduction - physiology Sinoatrial Node - metabolism Sinoatrial Node - pathology
ISSN:	1524-4571, 1524-4571
Online Access:	Get more information
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