High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells

Local, rhythmic, subsarcolemmal Ca2+ releases (LCRs) from the sarcoplasmic reticulum (SR) during diastolic depolarization in sinoatrial nodal cells (SANC) occur even in the basal state and activate an inward Na(+)-Ca2+ exchanger current that affects spontaneous beating. Why SANC can generate spontan...

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Bibliographic Details
Published in:	Circulation research Vol. 98; no. 4; p. 505
Main Authors:	Vinogradova, Tatiana M, Lyashkov, Alexey E, Zhu, Weizhong, Ruknudin, Abdul M, Sirenko, Syevda, Yang, Dongmei, Deo, Shekhar, Barlow, Matthew, Johnson, Shavsha, Caffrey, James L, Zhou, Ying-Ying, Xiao, Rui-Ping, Cheng, Heping, Stern, Michael D, Maltsev, Victor A, Lakatta, Edward G
Format:	Journal Article
Language:	English
Published:	United States 03.03.2006
Subjects:	Action Potentials Animals Calcium - metabolism Calcium Signaling Cyclic AMP - physiology Cyclic AMP-Dependent Protein Kinases - physiology Diastole - physiology Myocardial Contraction Myocytes, Cardiac - physiology Phosphorylation Rabbits Receptors, Adrenergic, beta - physiology Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum - metabolism Signal Transduction - physiology Sinoatrial Node - cytology Sinoatrial Node - physiology Sodium-Calcium Exchanger - physiology
ISSN:	1524-4571, 1524-4571
Online Access:	Get more information
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