Ursodeoxycholic acid inhibits the initiation and postinitiation phases of azoxymethane-induced colonic tumor development

Colonic tumorigenesis involves the processes of initiation and promotion/progression from normal epithelial cells to tumors. Studies in both humans and experimental models of colon cancer indicate that secondary bile acids promote tumor development. In contrast, we have demonstrated previously that...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention Jg. 11; H. 11; S. 1316
Hauptverfasser:	Wali, Ramesh K, Stoiber, Debra, Nguyen, Lan, Hart, John, Sitrin, Michael D, Brasitus, Thomas, Bissonnette, Marc
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2002
Schlagworte:	Animals Azoxymethane Cholagogues and Choleretics - therapeutic use Colonic Neoplasms - chemically induced Colonic Neoplasms - pathology Colonic Neoplasms - prevention & control Disease Models, Animal Disease Progression Dose-Response Relationship, Drug Incidence Male Rats Rats, Inbred F344 Time Factors Treatment Outcome Ursodeoxycholic Acid - therapeutic use
ISSN:	1055-9965
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