A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

DNA origami-based nanorobot presents thrombin to cause tumor infarction after specific recognition of a tumor vessel marker. Nanoscale robots have potential as intelligent drug delivery systems that respond to molecular triggers 1 , 2 , 3 , 4 . Using DNA origami we constructed an autonomous DNA robo...

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Bibliographic Details
Published in:	Nature biotechnology Vol. 36; no. 3; pp. 258 - 264
Main Authors:	Li, Suping, Jiang, Qiao, Liu, Shaoli, Zhang, Yinlong, Tian, Yanhua, Song, Chen, Wang, Jing, Zou, Yiguo, Anderson, Gregory J, Han, Jing-Yan, Chang, Yung, Liu, Yan, Zhang, Chen, Chen, Liang, Zhou, Guangbiao, Nie, Guangjun, Yan, Hao, Ding, Baoquan, Zhao, Yuliang
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.03.2018 Nature Publishing Group
Subjects:	13/31 13/51 14/19 14/3 14/34 14/5 59/57 631/67/1059/602 631/67/327 639/301/357/341 639/925/926/1048 639/925/926/1050 64/110 64/60 82/29 Agriculture Animal models Animals Aptamers Aptamers, Nucleotide - administration & dosage Aptamers, Nucleotide - genetics Bioinformatics Biomedical Engineering/Biotechnology Biomedicine Biotechnology Blood coagulation Blood vessels Blood Vessels - drug effects Blood Vessels - growth & development Blood Vessels - pathology Cancer Cancer treatment Cell Proliferation - drug effects Coagulation Deoxyribonucleic acid DNA DNA - administration & dosage DNA - chemistry Drug delivery Drug Delivery Systems Endothelial cells Endothelial Cells - drug effects Endothelial Cells - pathology Humans letter Life Sciences Mice Nanoparticles Neoplasms - drug therapy Neoplasms - pathology Nucleolin Payloads Phosphoproteins - genetics Protein Binding RNA-Binding Proteins - genetics Swine Technology application Thrombin Thrombin - administration & dosage Thrombin - chemistry Thromboembolism Thrombosis Tumors Xenograft Model Antitumor Assays
ISSN:	1087-0156, 1546-1696, 1546-1696
Online Access:	Get full text
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