Rat Models of Metabolic Syndrome

Metabolic syndrome is a complex disorder that comprises several other complex disorders, including obesity, hypertension, dyslipidemia, and diabetes. There are several rat models that encompass component features of MetS. Some models are inbred strains selected for one or more traits underlying MetS...

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Vydáno v:Methods in molecular biology (Clifton, N.J.) Ročník 2018; s. 269
Hlavní autor: Kwitek, Anne E
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.01.2019
Témata:
Animals
Cholesterol - metabolism
Disease Models, Animal
Genetic Predisposition to Disease
Lipoproteins, HDL - metabolism
Metabolic Syndrome - etiology
Metabolic Syndrome - genetics
Metabolic Syndrome - metabolism
Rats
Rats, Inbred Strains
Hypertension
Obesity
Rat inbred model
Rat genetic model
MetS
Rat disease model
Metabolic syndrome
ISSN:1940-6029, 1940-6029
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Popis
Shrnutí:Metabolic syndrome is a complex disorder that comprises several other complex disorders, including obesity, hypertension, dyslipidemia, and diabetes. There are several rat models that encompass component features of MetS. Some models are inbred strains selected for one or more traits underlying MetS; others are population models with genetic risk for MetS traits, are induced by environmental stressors such as diet, are spontaneous monogenic mutant models, or are congenic strains derived from a combination of these models. Together they can be studied to identify the genetic and physiological underpinnings of MetS to identify candidate genes or mechanisms for study in human MetS subjects.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1940-6029
1940-6029
DOI:10.1007/978-1-4939-9581-3_13