Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment of distant metastases. Additionally, the acquisition of invasive properties driven by epithelial-mesenchymal transition (EMT) is critica...

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Bibliographic Details

Published in:	The Journal of clinical investigation Vol. 122; no. 5; pp. 1849 - 1868
Main Authors:	Celia-Terrassa, Toni, Meca-Cortes, Oscar, Mateo, Francesca, De Paz, Alexia Martinez, Rubio, Nuria, Arnal-Estape, Anna, Ell, Brian J, Bermudo, Raquel, Diaz, Alba, Guerra-Rebollo, Marta, Lozano, Juan Jose, Estaras, Conchi, Ulloa, Catalina, Alvarez-Simon, Daniel, Mila, Jordi, Vilella, Ramon, Paciucci, Rosanna, Martinez-Balbas, Marian, De Herreros, Antonio Garcia, Gomis, Roger R, Kang, Yibin, Blanco, Jeronimo, Fernondez, Pedro L, Thomson, Timothy M
Format:	Journal Article
Language:	English
Published:	American Society for Clinical Investigation 01.05.2012
Subjects:	Cancer cells Epithelial tumors Metastasis Physiological aspects Stem cells
ISSN:	0021-9738
Online Access:	Get full text
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