Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases

Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activ...

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Vydané v:	Nutrition reviews Ročník 66; číslo 10; s. 591 - 596
Hlavní autori:	Knutson, Mitchell D, Leeuwenburgh, Christiaan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Malden, USA Blackwell Publishing Inc 01.10.2008 Wiley Oxford University Press
Predmet:	age Aging animal age animal proteins Animals Bioavailability Biological and medical sciences Biological Availability Cardiovascular Diseases Cardiovascular Diseases - drug therapy Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 - drug therapy drug effects drug therapy Drugs enzyme activation Enzyme Activation - drug effects Enzyme Activators Enzyme Activators - pharmacology Enzyme Activators - toxicity Enzymes Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans hydrolases Inflammation Inflammation - drug therapy laboratory animals life span literature reviews longevity metabolism Neurodegenerative Diseases Neurodegenerative Diseases - drug therapy noninfectious diseases Nutrient availability pharmacokinetics Pharmacology physiology polyphenol red wine resveratrol Rodents senescence sirtuin Sirtuin 1 Sirtuins Sirtuins - drug effects Sirtuins - physiology Stilbenes Stilbenes - pharmacokinetics Stilbenes - pharmacology Stilbenes - therapeutic use Studies therapeutic use toxicity transcription factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Wines Yeasts Senescence Disease Ageing life span Rodentia Longevity Red wine Vertebrata Polyphenol Mammalia Mouse sirtuin Resveratrol Age Food
ISSN:	0029-6643, 1753-4887, 1753-4887
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Shrnutí:	Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of mice fed high-fat diets. Resveratrol appears to mediate these effects partly by activating SIRT1, a deacetylase enzyme that regulates the activity of several transcriptional factors and enzymes responsive to nutrient availability. However, few foods contain resveratrol and humans metabolize it extensively, resulting in very low systemic bioavailability. Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders.
Bibliografia:	ArticleID:NURE109 ark:/67375/WNG-51ZJ9M8D-K istex:3AC7DCE4DFDBED2D0520E022E2B4D83031466B63 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-2 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3
ISSN:	0029-6643 1753-4887 1753-4887
DOI:	10.1111/j.1753-4887.2008.00109.x