The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C

Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular domain increases the levels of intracellular cGMP. The intracellular domain of these receptors is composed of a kinase homology domain (KHD), a linker of approximately 70 amino acids, followed by the C-termi...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 284; no. 40; p. 27135
Main Authors:	Saha, Sayanti, Biswas, Kabir Hassan, Kondapalli, Chandana, Isloor, Nishitha, Visweswariah, Sandhya S
Format:	Journal Article
Language:	English
Published:	United States 02.10.2009
Subjects:	Amino Acid Sequence Animals Cell Line Detergents - pharmacology Enzyme Activation - drug effects Guanylate Cyclase - chemistry Guanylate Cyclase - genetics Guanylate Cyclase - metabolism Humans Hydrophobic and Hydrophilic Interactions Ligands Mice Models, Molecular Molecular Sequence Data Mutagenesis Point Mutation Protein Structure, Tertiary Rats Receptors, Enterotoxin Receptors, Guanylate Cyclase-Coupled Receptors, Peptide - chemistry Receptors, Peptide - genetics Receptors, Peptide - metabolism
ISSN:	1083-351X, 1083-351X
Online Access:	Get more information
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