Risk of first-generation H₁-antihistamines: a GA²LEN position paper

To cite this article: Church MK, Maurer M, Simons FER, Bindslev-Jensen C, van Cauwenberge P, Bousquet J, Holgate ST, Zuberbier T. Risk of first-generation H₁-antihistamines: a GA²LEN position paper. Allergy 2010; 65: 459-466. First-generation H₁-antihistamines obtained without prescription are the m...

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Vydané v:Allergy (Copenhagen) Ročník 65; číslo 4; s. 459 - 466
Hlavní autori: Church, M.K, Maurer, M, Simons, F.E.R, Bindslev-Jensen, C, van Cauwenberge, P, Bousquet, J, Holgate, S.T, Zuberbier, T
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.04.2010
Blackwell Publishing Ltd
Blackwell
Predmet:
adverse event
allergic rhinitis
Biological and medical sciences
cognition
cognitive function
Consumer protection
Dermatology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Histamine
Medical sciences
Non tumoral diseases
Nonprescription drugs
Otorhinolaryngology. Stomatology
Patient safety
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
sedation
Side effects
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
cognitive function
Allergy
Immunopathology
Nose disease
Rhinitis
Dermatology
Position
Toxicity
Risk
adverse event
Cognition
Sedation
Antihistaminic
Immunology
Risk factor
Secondary effect
ENT disease
Paper
allergic rhinitis
ISSN:0105-4538, 1398-9995
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Shrnutí:To cite this article: Church MK, Maurer M, Simons FER, Bindslev-Jensen C, van Cauwenberge P, Bousquet J, Holgate ST, Zuberbier T. Risk of first-generation H₁-antihistamines: a GA²LEN position paper. Allergy 2010; 65: 459-466. First-generation H₁-antihistamines obtained without prescription are the most frequent form of self-medication for allergic diseases, coughs and colds and insomnia even though they have potentially dangerous unwanted effects which are not recognized by the general public. To increase consumer protection by bringing to the attention of regulatory authorities, physicians and the general public the potential dangers of the indiscriminate use first-generation H₁-antihistamines purchased over-the counter in the absence of appropriate medical supervision. A GA²LEN (Global Allergy and Asthma European Network) task force assessed the unwanted side-effects and potential dangers of first-generation H1-antihistamines by reviewing the literature (Medline and Embase) and performing a media audit of US coverage from 1996 to 2008 of accidents and fatal adverse events in which these drugs were implicated. First-generation H₁-antihistamines, all of which are sedating, are generally regarded as safe by laypersons and healthcare professionals because of their long-standing use. However, they reduce rapid eye movement (REM)-sleep, impair learning and reduce work efficiency. They are implicated in civil aviation, motor vehicle and boating accidents, deaths as a result of accidental or intentional overdosing in infants and young children and suicide in teenagers and adults. Some exhibit cardiotoxicity in overdose. This review raises the issue of better consumer protection by recommending that older first-generation H₁-antihistamines should no longer be available over-the-counter as prescription- free drugs for self-medication of allergic and other diseases now that newer second- generation nonsedating H₁-antihistamines with superior risk/benefit ratios are widely available at competitive prices.
Bibliografia:http://dx.doi.org/10.1111/j.1398-9995.2009.02325.x
Edited by: Thomas Bieber
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ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2009.02325.x