A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a prefusion stabilized spike protein (ChAd-SARS-CoV-2-S) in challenge studies with severe acute respir...

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Veröffentlicht in:	Cell Jg. 183; H. 1; S. 169
Hauptverfasser:	Hassan, Ahmed O, Kafai, Natasha M, Dmitriev, Igor P, Fox, Julie M, Smith, Brittany K, Harvey, Ian B, Chen, Rita E, Winkler, Emma S, Wessel, Alex W, Case, James Brett, Kashentseva, Elena, McCune, Broc T, Bailey, Adam L, Zhao, Haiyan, VanBlargan, Laura A, Dai, Ya-Nan, Ma, Meisheng, Adams, Lucas J, Shrihari, Swathi, Danis, Jonathan E, Gralinski, Lisa E, Hou, Yixuan J, Schäfer, Alexandra, Kim, Arthur S, Keeler, Shamus P, Weiskopf, Daniela, Baric, Ralph S, Holtzman, Michael J, Fremont, Daved H, Curiel, David T, Diamond, Michael S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2020
Schlagworte:	Adenoviridae - genetics Administration, Intranasal Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Chlorocebus aethiops Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - prevention & control COVID-19 COVID-19 Vaccines Female HEK293 Cells Humans Immunogenicity, Vaccine Injections, Intramuscular Mice Mice, Inbred BALB C Pandemics Pneumonia, Viral - immunology Pneumonia, Viral - pathology Respiratory Mucosa - immunology Respiratory Mucosa - pathology Respiratory Mucosa - virology Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Vero Cells Viral Vaccines - administration & dosage Viral Vaccines - immunology COVID-19 pathogenesis IgA SARS-CoV-2 vaccine antibody intranasal protection T cells mucosal immunity
ISSN:	1097-4172, 1097-4172
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