A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a prefusion stabilized spike protein (ChAd-SARS-CoV-2-S) in challenge studies with severe acute respir...

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Bibliographic Details
Published in:	Cell Vol. 183; no. 1; p. 169
Main Authors:	Hassan, Ahmed O, Kafai, Natasha M, Dmitriev, Igor P, Fox, Julie M, Smith, Brittany K, Harvey, Ian B, Chen, Rita E, Winkler, Emma S, Wessel, Alex W, Case, James Brett, Kashentseva, Elena, McCune, Broc T, Bailey, Adam L, Zhao, Haiyan, VanBlargan, Laura A, Dai, Ya-Nan, Ma, Meisheng, Adams, Lucas J, Shrihari, Swathi, Danis, Jonathan E, Gralinski, Lisa E, Hou, Yixuan J, Schäfer, Alexandra, Kim, Arthur S, Keeler, Shamus P, Weiskopf, Daniela, Baric, Ralph S, Holtzman, Michael J, Fremont, Daved H, Curiel, David T, Diamond, Michael S
Format:	Journal Article
Language:	English
Published:	United States 01.10.2020
Subjects:	Adenoviridae - genetics Administration, Intranasal Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Chlorocebus aethiops Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - prevention & control COVID-19 COVID-19 Vaccines Female HEK293 Cells Humans Immunogenicity, Vaccine Injections, Intramuscular Mice Mice, Inbred BALB C Pandemics Pneumonia, Viral - immunology Pneumonia, Viral - pathology Respiratory Mucosa - immunology Respiratory Mucosa - pathology Respiratory Mucosa - virology Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Vero Cells Viral Vaccines - administration & dosage Viral Vaccines - immunology COVID-19 pathogenesis IgA SARS-CoV-2 vaccine antibody intranasal protection T cells mucosal immunity
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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