Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies

Checkpoint blockade has formally demonstrated that reactivating anti-tumor immune responses can regress tumors. However, this only occurs in a fraction of patients. Incorporating these therapies in more powerful combinations is thus a logical next step. Here, we review functional roles of immune che...

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Vydané v:	Cancer cell Ročník 33; číslo 4; s. 581
Hlavní autori:	Zappasodi, Roberta, Merghoub, Taha, Wolchok, Jedd D
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 09.04.2018
Predmet:	Antibodies, Blocking - therapeutic use B7-H1 Antigen - immunology Clinical Trials as Topic Combined Modality Therapy - methods CTLA-4 Antigen - immunology Humans Immunotherapy - methods Neoplasms - immunology Neoplasms - therapy Programmed Cell Death 1 Receptor - immunology Tumor Burden - drug effects tumor immunology immunotherapy-based combinations cancer immunotherapy immune checkpoint blockade
ISSN:	1878-3686, 1878-3686
On-line prístup:	Zistit podrobnosti o prístupe
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