A rare NAB2ex6::STAT6ex3 fusion identified in a large pelvic epithelioid and cystic high-risk solitary fibrous tumor (SFT)

Solitary Fibrous Tumour (SFT) is a fibroblastic mesenchymal neoplasm with variable clinical behaviour with a genetic hallmark of recurrent fusion of NAB2 and STAT6 genes. More than 40 fusion variants have been reported and the NAB2ex6::STAT6ex16/17 groups have been found to carry significant higher...

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Vydáno v:Human Pathology Reports Ročník 42; s. 300806
Hlavní autoři: Nandi, Jhuma, Peeples, Mary, Stephenson, Ruth D., Gottshall, Lauren, Ghodoussipour, Saum, Becker, Murray, Riedlinger, Gregory M., Li, Lin
Médium: Journal Article
Jazyk:angličtina
Vydáno: Elsevier Inc 01.11.2025
Témata:
Epithelioid
Exon
Fusion
NAB2
Pathology
Pelvic
Solitary fibrous tumor (SFT)
STAT6
Solitary fibrous tumor (SFT)
Exon
NAB2
STAT6
Pelvic
Fusion
Epithelioid
ISSN:2772-736X, 2772-736X
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Shrnutí:Solitary Fibrous Tumour (SFT) is a fibroblastic mesenchymal neoplasm with variable clinical behaviour with a genetic hallmark of recurrent fusion of NAB2 and STAT6 genes. More than 40 fusion variants have been reported and the NAB2ex6::STAT6ex16/17 groups have been found to carry significant higher risk of recurrence. We reported here a rare NAB2ex6::STAT6ex3 fusion found in a large pelvic epithelioid and cystic high risk SFT in a 65-year-old women. Significantly the molecular findings in our patient correlate with the patient’s clinical-pathological high-risk features, expanding the landscape of our knowledge of SFT.
ISSN:2772-736X
2772-736X
DOI:10.1016/j.hpr.2025.300806