Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc-receptor-expressing immune cells, including neutrophils. However, the mechanism(s) by which neutrophils kill antibody-opsoni...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 23; H. 13; S. 3946 - 3959.e6
Hauptverfasser:	Matlung, Hanke L., Babes, Liane, Zhao, Xi Wen, van Houdt, Michel, Treffers, Louise W., van Rees, Dieke J., Franke, Katka, Schornagel, Karin, Verkuijlen, Paul, Janssen, Hans, Halonen, Pasi, Lieftink, Cor, Beijersbergen, Roderick L., Leusen, Jeanette H.W., Boelens, Jaap J., Kuhnle, Ingrid, van der Werff Ten Bosch, Jutte, Seeger, Karl, Rutella, Sergio, Pagliara, Daria, Matozaki, Takashi, Suzuki, Eiji, Menke-van der Houven van Oordt, Catharina Willemien, van Bruggen, Robin, Roos, Dirk, van Lier, Rene A.W., Kuijpers, Taco W., Kubes, Paul, van den Berg, Timo K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 26.06.2018 Elsevier
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antibody-Dependent Cell Cytotoxicity antibody-dependent cellular cytotoxicity CD11b Antigen - metabolism CD18 Antigens - metabolism CD47 Antigen - metabolism CD47-SIRPα interaction Cell Line, Tumor Female Humans Male Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Neoplasms - drug therapy Neoplasms - immunology Neoplasms - pathology neutrophils Neutrophils - immunology Receptors, IgG - metabolism Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Transplantation, Homologous trogocytosis trogoptosis trogocytosis trogoptosis antibody-dependent cellular cytotoxicity CD47-SIRPα interaction neutrophils
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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