Genetic modifiers of β-thalassemia and clinical severity as assessed by age at first transfusion

The clinical and hematologic features of β-thalassemia are modulated by different factors, resulting in a wide range of clinical severity. The main factors are the type of disease-causing mutation and the ability to produce α-globin and γ-globin chains. In the present study we investigated the respe...

Full description

Saved in:

Bibliographic Details
Published in:	Haematologica (Roma) Vol. 97; no. 7; pp. 989 - 993
Main Authors:	DANJOU, Fabrice, ANNI, Franco, PERSEU, Lucia, SATTA, Stefania, DESSI, Carlo, LAI, Maria Eliana, FORTINA, Paolo, DEVOTO, Marcella, GALANELLO, Renzo
Format:	Journal Article
Language:	English
Published:	Pavia Ferrata Storti Foundation 01.07.2012
Subjects:	Adolescent Adult Age Factors alpha-Globins - genetics Anemias. Hemoglobinopathies beta-Globins - genetics beta-Thalassemia - genetics beta-Thalassemia - mortality beta-Thalassemia - pathology Biological and medical sciences Blood Transfusion Carrier Proteins - genetics Cohort Studies Diseases of red blood cells DNA Fingerprinting DNA, Intergenic - genetics Female Fetal Hemoglobin - genetics Genetic Loci Genetic Markers Hematologic and hematopoietic diseases Humans Male Medical sciences Middle Aged Nuclear Proteins - genetics Original and Brief Reports Polymorphism, Single Nucleotide Proportional Hazards Models Severity of Illness Index Survival Analysis thalassemia major Hemoglobinopathy Transfusion Hematology Hemopathy beta-thalassemia genetic modifiers thalassemia intermedia Genetic disease Fetal hemoglobin Hemolytic anemia β-Thalassemia Genetics Age
ISSN:	0390-6078, 1592-8721, 1592-8721
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!