Liver iron concentrations and urinary hepcidin in β-thalassemia

Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of iron...

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Bibliographic Details
Published in:	Haematologica (Roma) Vol. 92; no. 5; pp. 583 - 588
Main Authors:	ORIGA, Raffaella, GALANELLO, Renzo, GANZ, Tomas, GIAGU, Nicolina, MACCIONI, Liliana, FAA, Gavino, NEMETH, Elizabeta
Format:	Journal Article
Language:	English
Published:	Pavia Haematologica 01.05.2007 Ferrata Storti Foundation
Subjects:	Adolescent Adult Anemias. Hemoglobinopathies Antimicrobial Cationic Peptides - deficiency Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - physiology Antimicrobial Cationic Peptides - urine beta-Thalassemia - drug therapy beta-Thalassemia - genetics beta-Thalassemia - metabolism beta-Thalassemia - therapy Biological and medical sciences Blood Transfusion Chelation Therapy Combined Modality Therapy Deferoxamine - therapeutic use Diseases of red blood cells Erythropoiesis Female Ferritins - blood Ferritins - metabolism Gene Expression Regulation Hematologic and hematopoietic diseases Hepcidins Humans Intestinal Absorption Iron - analysis Iron - metabolism Iron Chelating Agents - therapeutic use Iron Overload - etiology Iron Overload - metabolism Iron, Dietary - pharmacokinetics Liver - chemistry Liver - metabolism Macrophages - metabolism Male Medical sciences Severity of Illness Index Transferrin - analysis iron absorption Hemoglobinopathy Ineffective erythropoiesis Hematology Digestive system Liver iron-loading anemia Hemopathy Iron Genetic disease Hemolytic anemia Absorption β-Thalassemia hepatic iron Hepcidin
ISSN:	0390-6078, 1592-8721, 1592-8721
Online Access:	Get full text
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