Alexithymia and apathy in Parkinson's disease: neurocognitive correlates

Non-motor symptoms such as neuropsychiatric and cognitive dysfunction have been found to be common in Parkinson's disease (PD) but the relation between such symptoms is poorly understood. We focused on alexithymia, an impairment of affective and cognitive emotional processing, as there is evide...

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Vydáno v:Behavioural neurology Ročník 27; číslo 4; s. 535 - 545
Hlavní autoři: Bogdanova, Yelena, Cronin-Golomb, Alice
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands IOS Press 01.01.2013
Wiley
Témata:
Affective Symptoms - complications
Affective Symptoms - psychology
Apathy
Case-Control Studies
Cognition Disorders - complications
Cognition Disorders - psychology
Depression - complications
Depression - psychology
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Parkinson Disease - complications
Parkinson Disease - psychology
Psychiatric Status Rating Scales
Research Report
ACC
right hemisphere
Non-motor symptoms
frontostriatal
basal ganglia
ISSN:1875-8584, 0953-4180, 1875-8584
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Shrnutí:Non-motor symptoms such as neuropsychiatric and cognitive dysfunction have been found to be common in Parkinson's disease (PD) but the relation between such symptoms is poorly understood. We focused on alexithymia, an impairment of affective and cognitive emotional processing, as there is evidence for its interaction with cognition in other disorders. Twenty-two non-demented PD patients and 22 matched normal control adults (NC) were administered rating scales assessing neuropsychiatric status, including alexithymia, apathy, and depression, and a series of neuropsychological tests. As expected, PD patients showed more alexithymia than NC, and there was a significant association between alexithymia and disease stage. Alexithymia was associated with performance on non-verbally mediated measures of executive and visuospatial function, but not on verbally mediated tasks. By contrast, there was no correlation between cognition and ratings of either depression or apathy. Our findings demonstrate a distinct association of alexithymia with non-verbal cognition in PD, implicating right hemisphere processes, and differentiate between alexithymia and other neuropsychiatric symptoms in regard to PD cognition.
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ISSN:1875-8584
0953-4180
1875-8584
DOI:10.3233/BEN-129021