The power of genetic diversity in genome-wide association studies of lipids

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use 1 . Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels 2 , he...

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Published in:	Nature (London) Vol. 600; no. 7890; pp. 675 - 679
Main Authors:	Ramdas, Shweta, Vedantam, Sailaja, Locke, Adam E., Narita, Akira, Choudhury, Ananyo, Trivedi, Bhavi, Zhu, Xiang, Gudbjartsson, Daniel F., Lingren, Todd, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Zhao, Wei, Weir, David R., Schmidt, Ellen M., Luan, Jian’an, Yoon, Kyungheon, Medina-Gomez, Carolina, Willemsen, Gonneke, Haworth, Simon, Warren, Helen R., Sabater-Lleal, Maria, Noordam, Raymond, Fiorillo, Edoardo, Wielscher, Matthias, Munz, Matthias, Zeng, Lingyao, Kurbasic, Azra, Daw, E. Warwick, Christensen, Henry, Verweij, Niek, Iha, Hiroyuki, Wong, Andrew, Yousri, Noha A., Arbeeva, Liubov, Li, Xiaohui, Takeuchi, Fumihiko, Spracklen, Cassandra N., Sung, Yun Ju, Hung, Yi-Jen, Chen, Shufeng, Meidtner, Karina, Bielak, Lawrence F., Lin, Maoxuan, Cade, Brian E., Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Obura, Morgan O., Highland, Heather M., Kawaguchi, Takahisa, Nalls, Mike A., Braund, Peter S., Giardoglou, Tota, de Kleijn, Dominique, Rallidis, Loukianos S., Hewitt, Alex W., Ohlsson, Claes, Mellström, Dan, Homuth, Georg, Chen, Y. Eugene, Bandinelli, Stefania, Kato, Norihiro, De Jager, Philip L., Mamakou, Vasiliki, Caulfield, Mark J., Kaprio, Jaakko, Bechayda, Sonny Augustin, den Hollander, Anneke I., Wilson, James G., Nelson, Amanda E., Cruz, Miguel, Lettre, Guillaume, Loos, Ruth J. F., Psaty, Bruce M., Brandslund, Ivan, Christensen, Kaare, Loeffler, Markus, Khera, Amit V., Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Wong, Tien-Yin, Peters, Annette, Gieger, Christian, Langenberg, Claudia, Morrison, Alanna C., North, Kari E., Holmes, Michael V., Justice, Anne E., Kooperberg, Charles, Wei, Wei-Qi, Åsvold, Bjørn Olav, Kamatani, Yoichiro, Thorsteinsdottir, Unnur, Chang, Kyong-Mi, Tamiya, Gen, Mohlke, Karen L., Boehnke, Michael, Natarajan, Pradeep, Brown, Christopher D.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.12.2021 Nature Publishing Group
Subjects:	45/43 631/114/2397 631/208/205/2138 692/499 692/700/459/1748 Basic Medicine Biobanks Blood Blood lipids Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - genetics Cholesterol Consortia Coronary artery disease Diagnosis Endocrinology and Diabetes Endokrinologi och diabetes Evaluation Gene frequency Gene mapping Genetic analysis Genetic aspects Genetic diversity Genetic Predisposition to Disease - genetics Genetic variance Genome-wide association studies Genome-Wide Association Study - methods Genomes Health aspects Heart diseases High density lipoprotein Hispanic people Humanities and Social Sciences Humans Linkage Disequilibrium Lipids Lipoproteins Measurement Medical and Health Sciences Medical Genetics and Genomics (including Gene Therapy) Medicin och hälsovetenskap Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Meta-analysis multidisciplinary Multifactorial Inheritance Polymorphism, Single Nucleotide - genetics Population Groups Precision medicine Risk analysis Risk factors Science Science (multidisciplinary) Systematic review Therapeutic targets United States Europe United Kingdom > UK
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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