A T 1 MRI detectable hyaluronic acid hydrogel for in vivo tracking after intracerebral injection in stroke

Injectable hydrogels have emerged as a promising strategy for treating stroke and neurodegenerative diseases, but their effectiveness depends on precise injection, defect filling, and long-term retention at the target site. While MRI can help visualize hydrogels, distinguishing them from fluid-fille...

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Vydané v:Journal of materials chemistry. B, Materials for biology and medicine Ročník 13; číslo 13; s. 4103
Hlavní autori: Said, Moustoifa, Jing, Jing, Montigon, Olivier, Collomb, Nora, Vossier, Frédérique, Chovelon, Benoît, El Amine, Bayan, Jeacomine, Isabelle, Lemasson, Benjamin, Barbier, Emmanuel Luc, Detante, Olivier, Rome, Claire, Auzély-Velty, Rachel
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 26.03.2025
Predmet:
Animals
Biocompatible Materials - chemistry
Brain - diagnostic imaging
Contrast Media - chemistry
Gadolinium - chemistry
Humans
Hyaluronic Acid - administration & dosage
Hyaluronic Acid - chemistry
Hydrogels - administration & dosage
Hydrogels - chemistry
Magnetic Resonance Imaging
Mice
Stroke - diagnostic imaging
Stroke - drug therapy
ISSN:2050-7518
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Shrnutí:Injectable hydrogels have emerged as a promising strategy for treating stroke and neurodegenerative diseases, but their effectiveness depends on precise injection, defect filling, and long-term retention at the target site. While MRI can help visualize hydrogels, distinguishing them from fluid-filled spaces, like a post-stroke cavity at a chronic stage, is challenging owing to their high water content and similar MR properties. In this study, a MRI detectable hyaluronic acid (HA) hydrogel that is injectable and self-healing was developed for tracking after intracerebral injection in stroke. This HA hydrogel was functionalized with a thermodynamically stable and kinetically inert gadolinium(III) complex for monitoring its long-term fate in the brain with -contrast enhanced MRI. The dynamic covalent cross-links based on boronate ester bonds in the hydrogel network ensured precise injection and instantaneous self-healing. The HA network did not induce adverse tissue response and was biocompatible with therapeutic cells (human adipose stromal/stem cells). Furthermore, this labeling strategy enabled accurate tracking of hydrogel distribution and degradation in stroke condition, allowing a better assessment of efficacy and safety. This MRI-visible hydrogel has significant potential as a scaffold for stem cells, growth factors, and/or drugs, paving the way for more effective treatments for brain disorders.
ISSN:2050-7518
DOI:10.1039/d4tb02722a