Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We used these engineered...

Full description

Saved in:

Bibliographic Details
Published in:	Nature (London) Vol. 517; no. 7536; pp. 583 - 588
Main Authors:	Konermann, Silvana, Brigham, Mark D., Trevino, Alexandro E., Joung, Julia, Abudayyeh, Omar O., Barcena, Clea, Hsu, Patrick D., Habib, Naomi, Gootenberg, Jonathan S., Nishimasu, Hiroshi, Nureki, Osamu, Zhang, Feng
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29.01.2015 Nature Publishing Group
Subjects:	45/23 631/337/572/2102 Cell Line, Tumor Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR-Associated Proteins - genetics CRISPR-Associated Proteins - metabolism CRISPR-Cas Systems - genetics Crystal structure DNA, Complementary - biosynthesis DNA, Complementary - genetics Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzymes Epigenetics Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Library Genetic aspects Genetic engineering Genetic Engineering - methods Genetic Loci - genetics Genetic regulation Genetic research Genetic Testing Genetic transcription Genome, Human - genetics Genomes Genomics Health aspects Humanities and Social Sciences Humans Indoles - pharmacology Melanoma Melanoma - drug therapy Melanoma - genetics multidisciplinary Nucleotide sequence Proteins Proto-Oncogene Proteins B-raf - antagonists & inhibitors Reproducibility of Results RNA, Untranslated - biosynthesis RNA, Untranslated - genetics RNA, Untranslated - metabolism Science Sulfonamides - pharmacology Transcription factors Transcriptional Activation - genetics Up-Regulation - genetics United States
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We used these engineered Cas9 activation complexes to investigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to demonstrate multiplexed activation of ten genes simultaneously, and to upregulate long intergenic non-coding RNA (lincRNA) transcripts. We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon activation, confer resistance to a BRAF inhibitor. The top hits included genes previously shown to be able to confer resistance, and novel candidates were validated using individual sgRNA and complementary DNA overexpression. A gene expression signature based on the top screening hits correlated with markers of BRAF inhibitor resistance in cell lines and patient-derived samples. These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. The CRISPR-Cas9 system, a powerful tool for genome editing, has been engineered to activate endogenous gene transcription specifically and potently on a genome-wide scale and applied to a large-scale gain-of-function screen for studying melanoma drug resistance. CRISPR-Cas9 used for gene-expression regulation The CRISPR-Cas9 system has emerged as a powerful tool for genome editing and transcriptional regulation of specific genes. Feng Zhang and colleagues have successfully modified the system to specifically and potently activate endogenous gene transcription on a genome-wide scale, such that it can be used for large-scale functional genomics screens. Application to a genome-wide screen of melanoma cells for genes which when overexpressed can confer resistance to a BRAF inhibitor demonstrates the feasibility of such screens, and also led to the discovery of potential new resistance mechanisms.
AbstractList	Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We used these engineered Cas9 activation complexes to investigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to demonstrate multiplexed activation of ten genes simultaneously, and to upregulate long intergenic non-coding RNA (lincRNA) transcripts. We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon activation, confer resistance to a BRAF inhibitor. The top hits included genes previously shown to be able to confer resistance, and novel candidates were validated using individual sgRNA and complementary DNA overexpression. A gene expression signature based on the top screening hits correlated with markers of BRAF inhibitor resistance in cell lines and patient-derived samples. These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology.Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We used these engineered Cas9 activation complexes to investigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to demonstrate multiplexed activation of ten genes simultaneously, and to upregulate long intergenic non-coding RNA (lincRNA) transcripts. We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon activation, confer resistance to a BRAF inhibitor. The top hits included genes previously shown to be able to confer resistance, and novel candidates were validated using individual sgRNA and complementary DNA overexpression. A gene expression signature based on the top screening hits correlated with markers of BRAF inhibitor resistance in cell lines and patient-derived samples. These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We used these engineered Cas9 activation complexes to investigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to demonstrate multiplexed activation of ten genes simultaneously, and to upregulate long intergenic non-coding RNA (lincRNA) transcripts. We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon activation, confer resistance to a BRAF inhibitor. The top hits included genes previously shown to be able to confer resistance, and novel candidates were validated using individual sgRNA and complementary DNA overexpression. A gene expression signature based on the top screening hits correlated with markers of BRAF inhibitor resistance in cell lines and patient-derived samples. These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We used these engineered Cas9 activation complexes to investigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to demonstrate multiplexed activation of ten genes simultaneously, and to upregulate long intergenic non-coding RNA (lincRNA) transcripts. We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon activation, confer resistance to a BRAF inhibitor. The top hits included genes previously shown to be able to confer resistance, and novel candidates were validated using individual sgRNA and complementary DNA overexpression. A gene expression signature based on the top screening hits correlated with markers of BRAF inhibitor resistance in cell lines and patient-derived samples. These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. The CRISPR-Cas9 system, a powerful tool for genome editing, has been engineered to activate endogenous gene transcription specifically and potently on a genome-wide scale and applied to a large-scale gain-of-function screen for studying melanoma drug resistance. CRISPR-Cas9 used for gene-expression regulation The CRISPR-Cas9 system has emerged as a powerful tool for genome editing and transcriptional regulation of specific genes. Feng Zhang and colleagues have successfully modified the system to specifically and potently activate endogenous gene transcription on a genome-wide scale, such that it can be used for large-scale functional genomics screens. Application to a genome-wide screen of melanoma cells for genes which when overexpressed can confer resistance to a BRAF inhibitor demonstrates the feasibility of such screens, and also led to the discovery of potential new resistance mechanisms. Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We used these engineered Cas9 activation complexes to investigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to demonstrate multiplexed activation of ten genes simultaneously, and to upregulate long intergenic non-coding RNA (lincRNA) transcripts. We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon activation, confer resistance to a BRAF inhibitor. The top hits included genes previously shown to be able to confer resistance, and novel candidates were validated using individual sgRNA and complementary DNA overexpression. A gene expression signature based on the top screening hits correlated with markers of BRAF inhibitor resistance in cell lines and patient-derived samples. These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. The CRISPR-Cas9 system, a powerful tool for genome editing, has been engineered to activate endogenous gene transcription specifically and potently on a genome-wide scale and applied to a large-scale gain-of-function screen for studying melanoma drug resistance. CRISPR-Cas9 used for gene-expression regulation The CRISPR-Cas9 system has emerged as a powerful tool for genome editing and transcriptional regulation of specific genes. Feng Zhang and colleagues have successfully modified the system to specifically and potently activate endogenous gene transcription on a genome-wide scale, such that it can be used for large-scale functional genomics screens. Application to a genome-wide screen of melanoma cells for genes which when overexpressed can confer resistance to a BRAF inhibitor demonstrates the feasibility of such screens, and also led to the discovery of potential new resistance mechanisms. Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. Expected and potentially novel resistance genes are enriched in the top hits and are validated using individual sgRNA as well as cDNA overexpression. The signature of our top screening hits is significantly correlated with gene expression data from clinical melanoma samples. These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology.
Audience	Academic
Author	Konermann, Silvana Trevino, Alexandro E. Habib, Naomi Nishimasu, Hiroshi Nureki, Osamu Joung, Julia Abudayyeh, Omar O. Barcena, Clea Brigham, Mark D. Gootenberg, Jonathan S. Hsu, Patrick D. Zhang, Feng
AuthorAffiliation	1 Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA 4 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2 McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 5 Department of Systems Biology, Harvard Medical School, Boston, MA 02115 7 JST, PRESTO, 2-11-16 Yayoi, Bunkyo, Tokyo, 113-0032, Japan 6 Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo, Tokyo, 113-0032, Japan
AuthorAffiliation_xml	– name: 2 McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA – name: 6 Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo, Tokyo, 113-0032, Japan – name: 7 JST, PRESTO, 2-11-16 Yayoi, Bunkyo, Tokyo, 113-0032, Japan – name: 5 Department of Systems Biology, Harvard Medical School, Boston, MA 02115 – name: 4 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA – name: 1 Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA – name: 3 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Author_xml	– sequence: 1 givenname: Silvana surname: Konermann fullname: Konermann, Silvana organization: Broad Institute of MIT and Harvard, 75 Ames Street, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Department of Biological Engineering, Massachusetts Institute of Technology – sequence: 2 givenname: Mark D. surname: Brigham fullname: Brigham, Mark D. organization: Broad Institute of MIT and Harvard, 75 Ames Street, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Department of Biological Engineering, Massachusetts Institute of Technology – sequence: 3 givenname: Alexandro E. surname: Trevino fullname: Trevino, Alexandro E. organization: Broad Institute of MIT and Harvard, 75 Ames Street, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Department of Biological Engineering, Massachusetts Institute of Technology – sequence: 4 givenname: Julia surname: Joung fullname: Joung, Julia organization: Broad Institute of MIT and Harvard, 75 Ames Street, Department of Biological Engineering, Massachusetts Institute of Technology – sequence: 5 givenname: Omar O. surname: Abudayyeh fullname: Abudayyeh, Omar O. organization: Broad Institute of MIT and Harvard, 75 Ames Street, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Department of Biological Engineering, Massachusetts Institute of Technology – sequence: 6 givenname: Clea surname: Barcena fullname: Barcena, Clea organization: Broad Institute of MIT and Harvard, 75 Ames Street, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Department of Biological Engineering, Massachusetts Institute of Technology – sequence: 7 givenname: Patrick D. surname: Hsu fullname: Hsu, Patrick D. organization: Broad Institute of MIT and Harvard, 75 Ames Street, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Department of Biological Engineering, Massachusetts Institute of Technology – sequence: 8 givenname: Naomi surname: Habib fullname: Habib, Naomi organization: Broad Institute of MIT and Harvard, 75 Ames Street – sequence: 9 givenname: Jonathan S. surname: Gootenberg fullname: Gootenberg, Jonathan S. organization: Broad Institute of MIT and Harvard, 75 Ames Street, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Department of Systems Biology, Harvard Medical School – sequence: 10 givenname: Hiroshi surname: Nishimasu fullname: Nishimasu, Hiroshi organization: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi Bunkyo, Tokyo 113-0032, Japan, JST, PRESTO 2-11-16 Yayoi Bunkyo, Tokyo 113-0032, Japan – sequence: 11 givenname: Osamu surname: Nureki fullname: Nureki, Osamu organization: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi Bunkyo, Tokyo 113-0032, Japan – sequence: 12 givenname: Feng surname: Zhang fullname: Zhang, Feng email: zhang@broadinstitute.org organization: Broad Institute of MIT and Harvard, 75 Ames Street, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Department of Biological Engineering, Massachusetts Institute of Technology
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25494202$$D View this record in MEDLINE/PubMed
BookMark	eNqNk89v0zAUgC00xH7AiTuK4AKCDDt2bPeCNFUwKlUCdXC2XOcleErszk6m7b_HXcdIpw6mHKI43_vee7bfIdpz3gFCLwk-JpjKj073QwDCCOVP0AFhgueMS7GHDjAuZI4l5fvoMMZzjHFJBHuG9ouSTViBiwM0PwXnO8ij0S1kfdAummBXvfVOt5k2vb3U649seZ1pl4FrrAMIUGXTxezs-yKf6jjJjO9WLVw9R09r3UZ4cfs-Qj-_fP4x_ZrPv53Opifz3EhJ-pyaSlMoKNDa1FhwscSiNLSiVaWLJTMY03rCmakZLsWyAFxWotTMCMyF1JzQI_Rp410Nyw4qAy4V3qpVsJ0O18prq7b_OPtLNf5SsdQ0pzwJ3t4Kgr8YIPaqs9FA22oHfoiK8LJgRSnxOtebe-i5H0LanBuKlHQiKP1LNWkblXW1T3nNWqpOOMckyUr5T4ql06FSynVx-Q6qAQeplXT0tU3LW9bH8GP_6x28WdkLNZY-CI1Nxzug9FTQWbOz1EcFjDO82wpITA9XfaOHGNXsbLEt_x879r4a36C7q_NnMBLwfgOY4GMMUN8hBKv12KnR2CWa3KON7W_mJvVn2wdiPmxiYjK7BsLoYu3AfwMgSTfH
CODEN	NATUAS
CitedBy_id	crossref_primary_10_1002_smll_202309431 crossref_primary_10_3390_microorganisms13040927 crossref_primary_10_1042_BCJ20170025 crossref_primary_10_1016_j_tranon_2024_102264 crossref_primary_10_1016_j_omtn_2017_06_007 crossref_primary_10_1126_science_abq4822 crossref_primary_10_1038_s41434_023_00414_0 crossref_primary_10_1094_CCHEM_05_17_0101_FI crossref_primary_10_3389_fbioe_2020_00692 crossref_primary_10_4103_aja202193 crossref_primary_10_1093_nar_gkz210 crossref_primary_10_1016_j_arabjc_2022_103984 crossref_primary_10_1007_s42994_019_00007_9 crossref_primary_10_1038_s41467_017_01875_9 crossref_primary_10_1038_s41467_022_29205_8 crossref_primary_10_1002_j_2040_4603_2016_tb00681_x crossref_primary_10_1016_j_cotox_2019_02_009 crossref_primary_10_1146_annurev_biochem_060815_014607 crossref_primary_10_1016_j_neures_2021_03_008 crossref_primary_10_1089_crispr_2020_0106 crossref_primary_10_1111_pbi_12465 crossref_primary_10_1007_s00253_019_09726_x crossref_primary_10_1016_j_tibtech_2021_09_007 crossref_primary_10_1038_s41392_022_01211_8 crossref_primary_10_1186_s13062_024_00559_x crossref_primary_10_1038_s41592_024_02216_7 crossref_primary_10_1186_s13059_020_02118_9 crossref_primary_10_1002_btm2_70017 crossref_primary_10_1016_j_ymthe_2024_11_024 crossref_primary_10_3389_fcell_2020_604220 crossref_primary_10_1016_j_mcn_2020_103532 crossref_primary_10_1016_j_neuron_2022_08_011 crossref_primary_10_1089_crispr_2020_0108 crossref_primary_10_1186_s12885_021_08388_1 crossref_primary_10_15252_embj_201796941 crossref_primary_10_15252_emmm_202013162 crossref_primary_10_1016_j_addr_2019_11_005 crossref_primary_10_1016_j_copbio_2016_06_003 crossref_primary_10_1093_nar_gkab838 crossref_primary_10_1158_0008_5472_CAN_19_2578 crossref_primary_10_1186_s13046_024_03011_0 crossref_primary_10_1038_ncomms12009 crossref_primary_10_1038_nrg3956 crossref_primary_10_1007_s00425_022_03894_3 crossref_primary_10_1016_j_semcancer_2018_04_001 crossref_primary_10_1002_anie_201709201 crossref_primary_10_1093_nar_gkw1048 crossref_primary_10_1161_CIRCGEN_118_002082 crossref_primary_10_1186_s13059_020_02051_x crossref_primary_10_1038_s41467_022_31574_z crossref_primary_10_1016_j_aca_2020_03_058 crossref_primary_10_1002_advs_202202858 crossref_primary_10_1016_j_jbiotec_2019_05_306 crossref_primary_10_1038_s41467_021_22319_5 crossref_primary_10_1007_s11427_017_9029_9 crossref_primary_10_1016_j_crbiot_2025_100295 crossref_primary_10_1089_crispr_2020_0137 crossref_primary_10_1089_crispr_2020_0134 crossref_primary_10_1038_s41586_021_03589_x crossref_primary_10_1038_s41417_019_0116_8 crossref_primary_10_1016_j_cobme_2017_10_009 crossref_primary_10_1002_ctd2_142 crossref_primary_10_3390_biomedicines10030581 crossref_primary_10_1038_nbt_3715 crossref_primary_10_1016_j_biomaterials_2020_120225 crossref_primary_10_1038_ncomms11178 crossref_primary_10_7554_eLife_87722_3 crossref_primary_10_1002_iub_1697 crossref_primary_10_1007_s11816_023_00876_z crossref_primary_10_1016_j_cobme_2017_10_011 crossref_primary_10_3389_fnmol_2020_00168 crossref_primary_10_1093_nar_gkz267 crossref_primary_10_1016_j_omtn_2023_03_017 crossref_primary_10_1039_D5SC00918A crossref_primary_10_1016_j_preteyeres_2018_01_004 crossref_primary_10_1111_tpj_13100 crossref_primary_10_1016_j_bbcan_2015_09_003 crossref_primary_10_1016_j_molmet_2017_07_001 crossref_primary_10_1128_JVI_00211_19 crossref_primary_10_1038_s41467_021_24137_1 crossref_primary_10_1038_s41467_023_37542_5 crossref_primary_10_1063_5_0228874 crossref_primary_10_1016_j_cellin_2025_100254 crossref_primary_10_1007_s00018_023_05101_2 crossref_primary_10_1007_s11626_020_00469_y crossref_primary_10_1016_j_stem_2017_12_001 crossref_primary_10_1097_CM9_0000000000003088 crossref_primary_10_1186_s13059_015_0846_3 crossref_primary_10_1016_j_molcel_2019_04_011 crossref_primary_10_1016_j_exphem_2019_03_004 crossref_primary_10_1038_s41590_022_01224_z crossref_primary_10_1016_j_cell_2015_08_007 crossref_primary_10_1186_s12931_019_1253_1 crossref_primary_10_1038_nmeth_3630 crossref_primary_10_1038_s41386_022_01311_7 crossref_primary_10_1038_s41592_023_02036_1 crossref_primary_10_3389_fcell_2023_1220376 crossref_primary_10_1016_j_tig_2019_04_007 crossref_primary_10_1038_s41568_022_00441_w crossref_primary_10_1097_BS9_0000000000000123 crossref_primary_10_1111_cas_14637 crossref_primary_10_1002_bmm2_12025 crossref_primary_10_3389_fbioe_2022_901037 crossref_primary_10_1084_jem_20181895 crossref_primary_10_1016_j_cbpa_2017_06_003 crossref_primary_10_1016_j_tibtech_2020_10_012 crossref_primary_10_1136_jmedgenet_2014_102968 crossref_primary_10_1242_dmm_050669 crossref_primary_10_1016_j_ccell_2022_10_012 crossref_primary_10_1371_journal_ppat_1008777 crossref_primary_10_1007_s11886_024_02125_3 crossref_primary_10_1126_science_aaf5573 crossref_primary_10_1534_g3_116_032482 crossref_primary_10_3389_fmicb_2024_1498641 crossref_primary_10_1021_acssynbio_4c00569 crossref_primary_10_1186_s13059_025_03640_4 crossref_primary_10_1016_j_jare_2024_08_024 crossref_primary_10_1186_s13072_015_0023_7 crossref_primary_10_1186_s12864_019_5888_6 crossref_primary_10_1016_j_bios_2021_113073 crossref_primary_10_1111_pbi_13723 crossref_primary_10_1038_s41590_017_0032_8 crossref_primary_10_1016_j_chembiol_2017_06_011 crossref_primary_10_1016_j_talanta_2022_123773 crossref_primary_10_1200_JCO_2015_63_7793 crossref_primary_10_1016_j_chom_2023_08_001 crossref_primary_10_1016_j_copbio_2016_04_005 crossref_primary_10_1161_CIRCRESAHA_116_309727 crossref_primary_10_1038_s41467_019_08736_7 crossref_primary_10_1007_s43188_024_00249_w crossref_primary_10_1093_nar_gkz271 crossref_primary_10_1016_j_cels_2023_07_001 crossref_primary_10_1080_15592294_2023_2175522 crossref_primary_10_1016_j_bbrc_2017_03_076 crossref_primary_10_1002_biot_202100408 crossref_primary_10_1038_s41580_024_00769_1 crossref_primary_10_1002_advs_202101281 crossref_primary_10_1038_s41420_024_02186_x crossref_primary_10_1111_jpi_12787 crossref_primary_10_1016_j_molcel_2025_03_001 crossref_primary_10_1101_gr_199919_115 crossref_primary_10_1016_j_coisb_2017_02_002 crossref_primary_10_1002_dvdy_24414 crossref_primary_10_1002_advs_201801423 crossref_primary_10_1038_s41398_018_0182_y crossref_primary_10_1186_s13073_015_0178_7 crossref_primary_10_1002_advs_202104789 crossref_primary_10_1038_s41467_019_09974_5 crossref_primary_10_1016_j_jmb_2025_169209 crossref_primary_10_1371_journal_pone_0235530 crossref_primary_10_1016_j_jaci_2020_09_035 crossref_primary_10_1038_s41598_018_37940_6 crossref_primary_10_1016_j_virusres_2017_03_010 crossref_primary_10_1089_regen_2021_0003 crossref_primary_10_1093_procel_pwad013 crossref_primary_10_3390_life11111255 crossref_primary_10_1139_gen_2024_0088 crossref_primary_10_1039_C6NP00017G crossref_primary_10_1016_j_bbadis_2018_12_006 crossref_primary_10_1093_nar_gkaa177 crossref_primary_10_1016_j_celrep_2023_113311 crossref_primary_10_1038_s41598_017_06269_x crossref_primary_10_3390_ijms19040946 crossref_primary_10_1002_ps_7851 crossref_primary_10_3389_fpls_2021_689937 crossref_primary_10_1016_j_bbagen_2024_130580 crossref_primary_10_1038_s41569_021_00669_3 crossref_primary_10_3389_fendo_2018_00038 crossref_primary_10_3389_fphar_2021_779606 crossref_primary_10_1146_annurev_genom_091416_035537 crossref_primary_10_1038_s41593_017_0060_6 crossref_primary_10_1186_s13046_024_02995_z crossref_primary_10_3390_molecules27082434 crossref_primary_10_1080_07388551_2020_1808583 crossref_primary_10_3389_fncel_2019_00352 crossref_primary_10_1038_nmeth_4108 crossref_primary_10_1038_s41598_018_24956_1 crossref_primary_10_1016_j_nantod_2023_101992 crossref_primary_10_1038_s41467_020_14623_3 crossref_primary_10_3390_genes12101604 crossref_primary_10_1021_acssynbio_5c00358 crossref_primary_10_3390_ijms19040933 crossref_primary_10_1093_nar_gkad1108 crossref_primary_10_1073_pnas_1516305112 crossref_primary_10_1016_j_jbc_2024_107486 crossref_primary_10_1016_j_tibtech_2018_08_010 crossref_primary_10_1007_s42994_019_00003_z crossref_primary_10_1016_j_tim_2016_06_005 crossref_primary_10_12688_f1000research_12596_1 crossref_primary_10_3390_plants10081667 crossref_primary_10_1038_s41467_024_45163_9 crossref_primary_10_1016_j_addr_2022_114562 crossref_primary_10_71150_jm_2501008 crossref_primary_10_1093_nar_gkaf841 crossref_primary_10_1016_j_tibtech_2018_08_002 crossref_primary_10_1016_j_tig_2019_06_006 crossref_primary_10_1016_j_cell_2024_03_023 crossref_primary_10_1038_s41589_025_01860_0 crossref_primary_10_1038_s41467_018_04252_2 crossref_primary_10_1186_s13287_017_0511_8 crossref_primary_10_1093_nar_gkac344 crossref_primary_10_15302_J_QB_022_0299 crossref_primary_10_1016_j_cell_2024_03_020 crossref_primary_10_3390_v10040157 crossref_primary_10_1089_crispr_2023_0078 crossref_primary_10_1111_cpr_12818 crossref_primary_10_3389_fgene_2020_00855 crossref_primary_10_1101_gad_322495_118 crossref_primary_10_1016_j_ymben_2020_10_004 crossref_primary_10_15252_emmm_202114797 crossref_primary_10_1093_nar_gkaf423 crossref_primary_10_1038_s41422_021_00515_8 crossref_primary_10_3389_fimmu_2024_1412731 crossref_primary_10_1016_j_chembiol_2024_07_007 crossref_primary_10_1038_nm_3981 crossref_primary_10_1038_s41467_018_04158_z crossref_primary_10_1016_j_devcel_2019_07_013 crossref_primary_10_1186_s40779_015_0038_1 crossref_primary_10_1158_0008_5472_CAN_19_2924 crossref_primary_10_1016_j_copbio_2019_08_006 crossref_primary_10_4049_jimmunol_1900272 crossref_primary_10_1093_nar_gkw997 crossref_primary_10_1038_s41467_022_35041_7 crossref_primary_10_1038_gt_2017_35 crossref_primary_10_3389_fgene_2020_00851 crossref_primary_10_1007_s11248_017_0030_5 crossref_primary_10_1073_pnas_1611142114 crossref_primary_10_1002_wrna_1731 crossref_primary_10_1007_s12272_018_1029_z crossref_primary_10_1016_j_ijbiomac_2018_10_170 crossref_primary_10_1093_brain_awaa045 crossref_primary_10_1016_j_ajp_2025_104501 crossref_primary_10_1093_nar_gkae549 crossref_primary_10_1007_s12247_020_09496_4 crossref_primary_10_1007_s00011_025_02079_4 crossref_primary_10_1146_annurev_biophys_062215_010830 crossref_primary_10_3390_ijms21051574 crossref_primary_10_3390_ncrna7040079 crossref_primary_10_1186_s12934_017_0664_2 crossref_primary_10_1073_pnas_1707635114 crossref_primary_10_1038_s44325_024_00035_5 crossref_primary_10_1128_JVI_01324_18 crossref_primary_10_1016_j_jbiotec_2023_12_003 crossref_primary_10_1186_s13036_019_0170_7 crossref_primary_10_1016_j_molcel_2016_02_018 crossref_primary_10_1016_j_ccell_2018_10_015 crossref_primary_10_1016_j_pharmthera_2025_108862 crossref_primary_10_1016_j_molcel_2015_07_002 crossref_primary_10_1080_15384101_2019_1593650 crossref_primary_10_1016_j_jim_2016_09_006 crossref_primary_10_1093_nar_gkx829 crossref_primary_10_3390_ijms20153719 crossref_primary_10_1016_j_jgg_2017_04_009 crossref_primary_10_3389_fimmu_2018_02967 crossref_primary_10_1016_j_bios_2022_114712 crossref_primary_10_1146_annurev_cancerbio_030617_050455 crossref_primary_10_1016_j_rsci_2018_11_001 crossref_primary_10_1016_j_ymeth_2016_11_012 crossref_primary_10_1002_cpph_24 crossref_primary_10_1002_sae2_12014 crossref_primary_10_1002_ange_201609229 crossref_primary_10_1038_s41467_024_55104_1 crossref_primary_10_1039_C6CS00197A crossref_primary_10_1007_s00018_021_03832_8 crossref_primary_10_1371_journal_pone_0299513 crossref_primary_10_1016_j_molp_2021_09_015 crossref_primary_10_1534_genetics_115_181065 crossref_primary_10_1073_pnas_2310821121 crossref_primary_10_1016_j_mmm_2020_10_001 crossref_primary_10_1038_s41467_022_35504_x crossref_primary_10_1177_10738584221088244 crossref_primary_10_1016_j_bbcan_2020_188378 crossref_primary_10_1146_annurev_genom_083115_022258 crossref_primary_10_1038_nbt_3390 crossref_primary_10_1093_nar_gkv226 crossref_primary_10_1146_annurev_genet_120215_034902 crossref_primary_10_1242_jcs_256818 crossref_primary_10_15252_embr_201540809 crossref_primary_10_1158_2159_8290_CD_16_0154 crossref_primary_10_1126_science_aad5147 crossref_primary_10_3390_brainsci9010017 crossref_primary_10_1017_qpb_2025_3 crossref_primary_10_1038_ncomms10770 crossref_primary_10_1016_j_omtm_2021_03_018 crossref_primary_10_1016_j_cels_2023_05_002 crossref_primary_10_1002_1878_0261_13272 crossref_primary_10_1016_j_bioactmat_2021_02_008 crossref_primary_10_1007_s12031_017_1011_0 crossref_primary_10_1016_j_foodcont_2025_111200 crossref_primary_10_1099_jgv_0_001754 crossref_primary_10_3389_fgeed_2021_715697 crossref_primary_10_1186_s13073_021_00857_3 crossref_primary_10_7554_eLife_45973 crossref_primary_10_1038_nmeth_4038 crossref_primary_10_1093_nar_gkae591 crossref_primary_10_1093_stmcls_sxae092 crossref_primary_10_1139_cjpp_2023_0088 crossref_primary_10_1016_j_virol_2017_09_028 crossref_primary_10_1039_c6ib00140h crossref_primary_10_1002_advs_202412250 crossref_primary_10_1073_pnas_2016806118 crossref_primary_10_1146_annurev_genom_120423_013542 crossref_primary_10_1038_s41598_018_28178_3 crossref_primary_10_1007_s12015_023_10506_4 crossref_primary_10_1016_j_copbio_2020_04_005 crossref_primary_10_1016_j_scr_2016_10_011 crossref_primary_10_1371_journal_pone_0230203 crossref_primary_10_12688_f1000research_11113_1 crossref_primary_10_3390_ijms19041089 crossref_primary_10_1038_s41467_017_01804_w crossref_primary_10_1101_gr_190124_115 crossref_primary_10_1016_j_ibmb_2019_05_007 crossref_primary_10_1038_nprot_2018_005 crossref_primary_10_1161_CIRCRESAHA_122_320496 crossref_primary_10_1002_ange_201601708 crossref_primary_10_1016_j_critrevonc_2025_104916 crossref_primary_10_1016_j_tranon_2018_11_017 crossref_primary_10_3389_fbioe_2025_1336313 crossref_primary_10_1038_s41467_018_06951_2 crossref_primary_10_1016_j_chembiol_2024_05_005 crossref_primary_10_1073_pnas_2215553120 crossref_primary_10_1111_bjh_14297 crossref_primary_10_1016_j_stem_2018_09_003 crossref_primary_10_1186_s13059_018_1538_6 crossref_primary_10_1242_jcs_260031 crossref_primary_10_3390_cells11193045 crossref_primary_10_1016_j_jgg_2023_07_007 crossref_primary_10_1007_s00438_017_1350_0 crossref_primary_10_1016_j_copbio_2017_03_025 crossref_primary_10_1007_s10557_021_07158_2 crossref_primary_10_1002_advs_202004629 crossref_primary_10_1038_s41593_019_0338_y crossref_primary_10_1002_advs_201902552 crossref_primary_10_1111_apha_13087 crossref_primary_10_1016_j_ymthe_2023_03_024 crossref_primary_10_1080_15427528_2019_1678541 crossref_primary_10_1038_nrn_2015_2 crossref_primary_10_1016_j_semcancer_2018_02_008 crossref_primary_10_1128_mSphere_00474_21 crossref_primary_10_1089_ten_tea_2023_29046_abstracts crossref_primary_10_1002_jbmr_3086 crossref_primary_10_1038_s41467_020_15021_5 crossref_primary_10_3389_fphys_2018_01201 crossref_primary_10_1038_s41588_018_0060_9 crossref_primary_10_1186_s13072_019_0275_8 crossref_primary_10_1007_s00439_016_1713_3 crossref_primary_10_3390_ijms21124197 crossref_primary_10_1016_j_drudis_2014_12_016 crossref_primary_10_1134_S1990519X25030101 crossref_primary_10_3389_fmicb_2021_638096 crossref_primary_10_1186_s13059_015_0823_x crossref_primary_10_1093_nar_gkz605 crossref_primary_10_3390_genes11090976 crossref_primary_10_3390_jcdd8070072 crossref_primary_10_1038_nrrheum_2017_6 crossref_primary_10_1038_s12276_025_01463_8 crossref_primary_10_1016_j_jbiotec_2018_03_018 crossref_primary_10_1093_nar_gkaf017 crossref_primary_10_1093_hr_uhab037 crossref_primary_10_1016_j_mam_2025_101358 crossref_primary_10_1038_s41467_017_01408_4 crossref_primary_10_1038_s42003_024_06190_w crossref_primary_10_1038_s41467_025_58032_w crossref_primary_10_1016_j_cell_2022_04_034 crossref_primary_10_1089_cell_2017_0006 crossref_primary_10_1093_jamia_ocw007 crossref_primary_10_1038_ncomms14725 crossref_primary_10_1111_febs_16217 crossref_primary_10_3390_cells12081103 crossref_primary_10_3390_jcm8111782 crossref_primary_10_1002_hep_30414 crossref_primary_10_1016_j_mib_2015_08_007 crossref_primary_10_1016_j_neubiorev_2019_12_013 crossref_primary_10_1038_s41556_024_01448_1 crossref_primary_10_3389_fgeed_2023_1218328 crossref_primary_10_1016_j_berh_2024_101937 crossref_primary_10_1016_j_molcel_2021_08_008 crossref_primary_10_1038_s41467_025_60793_3 crossref_primary_10_1016_j_jbc_2022_102085 crossref_primary_10_1038_s41467_023_40788_8 crossref_primary_10_1002_ctm2_1087 crossref_primary_10_1038_s41467_022_31762_x crossref_primary_10_1080_03008207_2016_1194406 crossref_primary_10_1016_j_apsb_2019_09_003 crossref_primary_10_1016_j_bbrc_2018_08_158 crossref_primary_10_1016_j_molcel_2016_02_020 crossref_primary_10_1016_j_ymthe_2025_08_047 crossref_primary_10_1016_j_canlet_2018_10_035 crossref_primary_10_1038_s41467_018_05495_9 crossref_primary_10_1186_s13046_020_01814_5 crossref_primary_10_1007_s13238_017_0410_x crossref_primary_10_1016_j_csbj_2019_09_006 crossref_primary_10_1093_nar_gkaf074 crossref_primary_10_1016_j_yjmcc_2023_07_008 crossref_primary_10_1093_neuonc_noac068 crossref_primary_10_1101_gr_179044_114 crossref_primary_10_1038_s42255_020_0205_x crossref_primary_10_1016_j_cbpa_2019_05_020 crossref_primary_10_3390_cancers12123695 crossref_primary_10_1016_j_prp_2024_155785 crossref_primary_10_1038_mtna_2015_37 crossref_primary_10_1016_j_omtn_2024_102428 crossref_primary_10_1002_advs_202409004 crossref_primary_10_1002_1873_3468_13073 crossref_primary_10_3389_fcell_2024_1484955 crossref_primary_10_3389_fpls_2024_1370675 crossref_primary_10_1096_fj_202101507RR crossref_primary_10_1016_j_gene_2024_149075 crossref_primary_10_3109_07388551_2016_1165180 crossref_primary_10_1038_s41588_020_00749_z crossref_primary_10_1016_j_cell_2017_11_008 crossref_primary_10_1002_bit_28664 crossref_primary_10_1038_s41392_023_01309_7 crossref_primary_10_1093_nar_gkaa645 crossref_primary_10_1161_CIRCULATIONAHA_124_070279 crossref_primary_10_3390_foods11203248 crossref_primary_10_1002_EXP_20210081 crossref_primary_10_1016_j_omto_2022_02_007 crossref_primary_10_1002_ijc_29626 crossref_primary_10_1002_advs_202304519 crossref_primary_10_1007_s00335_017_9684_9 crossref_primary_10_1073_pnas_1517883113 crossref_primary_10_1016_j_tig_2015_03_010 crossref_primary_10_1016_j_yjmcc_2018_01_015 crossref_primary_10_1038_s41467_022_29292_7 crossref_primary_10_3389_fimmu_2023_1216344 crossref_primary_10_1038_s41598_021_00966_4 crossref_primary_10_1093_hmg_ddy120 crossref_primary_10_1186_s13059_016_0915_2 crossref_primary_10_1016_j_biochi_2015_03_025 crossref_primary_10_3390_ijms221810065 crossref_primary_10_7717_peerj_9046 crossref_primary_10_1016_j_gene_2020_145225 crossref_primary_10_1360_SSV_2025_0142 crossref_primary_10_1016_j_gene_2017_06_019 crossref_primary_10_3390_ijms25063271 crossref_primary_10_1016_j_copbio_2018_03_007 crossref_primary_10_3389_fcimb_2022_880030 crossref_primary_10_1002_jnr_23776 crossref_primary_10_1038_s41477_017_0046_0 crossref_primary_10_1038_s41592_018_0048_5 crossref_primary_10_3389_fgeed_2021_630600 crossref_primary_10_3390_ijms222212543 crossref_primary_10_1038_s41467_021_27290_9 crossref_primary_10_3390_v10010040 crossref_primary_10_1038_s41575_021_00465_x crossref_primary_10_1182_blood_2016_01_678151 crossref_primary_10_1002_ange_201504741 crossref_primary_10_1038_s41467_019_11513_1 crossref_primary_10_1038_s41434_023_00413_1 crossref_primary_10_1155_2020_2907623 crossref_primary_10_1016_j_jbiosc_2019_09_011 crossref_primary_10_1016_j_biomaterials_2023_122106 crossref_primary_10_1038_nbt_3659 crossref_primary_10_4252_wjsc_v13_i6_485 crossref_primary_10_1186_s12859_019_3151_4 crossref_primary_10_3389_fbioe_2019_00459 crossref_primary_10_1007_s40291_019_00391_4 crossref_primary_10_1016_j_ymeth_2019_05_003 crossref_primary_10_1016_j_molcel_2015_05_016 crossref_primary_10_1016_j_ccell_2023_03_015 crossref_primary_10_1016_j_molp_2020_11_002 crossref_primary_10_1155_2020_8483035 crossref_primary_10_1016_j_trac_2023_116931 crossref_primary_10_1016_j_biochi_2015_03_014 crossref_primary_10_1016_j_tcb_2021_12_001 crossref_primary_10_1038_s41467_021_21518_4 crossref_primary_10_1089_hum_2018_018 crossref_primary_10_1093_nar_gkaf093 crossref_primary_10_1534_g3_120_401614 crossref_primary_10_59717_j_xinn_med_2024_100050 crossref_primary_10_1007_s43152_020_00011_y crossref_primary_10_1016_j_jacc_2017_10_002 crossref_primary_10_1038_nrg_2015_10 crossref_primary_10_1038_s41467_022_34334_1 crossref_primary_10_1038_s41477_021_00953_7 crossref_primary_10_1007_s10142_025_01612_2 crossref_primary_10_1146_annurev_micro_091014_104441 crossref_primary_10_1016_j_jgg_2019_03_006 crossref_primary_10_1016_j_jare_2024_10_027 crossref_primary_10_1016_j_jmb_2018_06_026 crossref_primary_10_1038_s41467_019_08541_2 crossref_primary_10_3389_fnins_2020_579062 crossref_primary_10_1089_crispr_2020_0029 crossref_primary_10_3390_ijms25094816 crossref_primary_10_1038_s41467_023_43264_5 crossref_primary_10_1002_advs_202300195 crossref_primary_10_1111_wrr_12881 crossref_primary_10_26508_lsa_201900528 crossref_primary_10_1093_nar_gky051 crossref_primary_10_1186_s12967_024_05235_2 crossref_primary_10_1016_j_biochi_2019_09_003 crossref_primary_10_1111_cmi_12693 crossref_primary_10_1159_000515845 crossref_primary_10_1016_j_molcel_2021_03_033 crossref_primary_10_1016_j_ymthe_2022_08_008 crossref_primary_10_1146_annurev_cancerbio_030518_055742 crossref_primary_10_1002_ajmg_c_31444 crossref_primary_10_1093_nar_gkab519 crossref_primary_10_1002_cbic_201700635 crossref_primary_10_1016_j_jplph_2020_153332 crossref_primary_10_1007_s00018_022_04175_8 crossref_primary_10_1016_j_tibtech_2015_05_001 crossref_primary_10_1172_JCI183697 crossref_primary_10_1038_s41467_017_02075_1 crossref_primary_10_1007_s00005_016_0427_5 crossref_primary_10_1186_s13073_017_0477_2 crossref_primary_10_1002_jgm_3721 crossref_primary_10_1093_nar_gkaa671 crossref_primary_10_1016_j_bcp_2020_114228 crossref_primary_10_1016_j_jconrel_2025_113853 crossref_primary_10_1242_dev_182667 crossref_primary_10_1093_nar_gkab527 crossref_primary_10_1161_CIRCRESAHA_117_306290 crossref_primary_10_1007_s11427_023_2571_0 crossref_primary_10_1038_nmeth_3993 crossref_primary_10_1016_j_canlet_2016_03_029 crossref_primary_10_1007_s11248_021_00252_z crossref_primary_10_1073_pnas_1921786117 crossref_primary_10_1038_s41598_017_06468_6 crossref_primary_10_1038_s10038_017_0377_8 crossref_primary_10_1038_s41586_019_1383_0 crossref_primary_10_3233_JHD_160222 crossref_primary_10_1007_s11427_021_1990_5 crossref_primary_10_12688_f1000research_8682_1 crossref_primary_10_1038_s43587_022_00186_z crossref_primary_10_1093_pcmedi_pbab015 crossref_primary_10_1073_pnas_2213715120 crossref_primary_10_1007_s00018_016_2271_5 crossref_primary_10_1038_s41598_020_59812_8 crossref_primary_10_1002_ijch_202200056 crossref_primary_10_1111_tpj_13899 crossref_primary_10_3389_fgene_2016_00047 crossref_primary_10_1038_s12276_025_01500_6 crossref_primary_10_1016_j_bios_2025_117221 crossref_primary_10_1242_dmm_050533 crossref_primary_10_1016_j_ymthe_2019_09_024 crossref_primary_10_1038_s41698_024_00554_5 crossref_primary_10_3390_agronomy7030058 crossref_primary_10_1111_pbi_13834 crossref_primary_10_1002_ange_202009240 crossref_primary_10_1038_s41580_022_00571_x crossref_primary_10_1007_s12033_021_00345_4 crossref_primary_10_1089_crispr_2020_0064 crossref_primary_10_1186_s12935_019_0726_0 crossref_primary_10_1038_s41573_020_0083_7 crossref_primary_10_1002_bab_2200 crossref_primary_10_1016_j_archger_2023_105283 crossref_primary_10_1089_crispr_2022_0056 crossref_primary_10_4049_jimmunol_1701616 crossref_primary_10_1089_crispr_2022_0052 crossref_primary_10_1016_j_copbio_2015_11_008 crossref_primary_10_1016_j_tibtech_2017_06_004 crossref_primary_10_1016_j_stem_2022_03_015 crossref_primary_10_1089_crispr_2020_0035 crossref_primary_10_3389_fcell_2020_00347 crossref_primary_10_1186_s12896_022_00741_x crossref_primary_10_1007_s11814_022_1076_5 crossref_primary_10_3389_fbioe_2020_00711 crossref_primary_10_1038_s41598_019_54179_x crossref_primary_10_1186_s13148_023_01546_1 crossref_primary_10_3390_plants10102055 crossref_primary_10_1093_nar_gkaa231 crossref_primary_10_1016_j_biotechadv_2024_108382 crossref_primary_10_1016_j_chembiol_2021_04_011 crossref_primary_10_1016_j_visres_2023_108315 crossref_primary_10_1016_j_coph_2015_05_004 crossref_primary_10_1038_s41576_019_0093_7 crossref_primary_10_1126_science_aat6982 crossref_primary_10_1186_s13068_018_1181_1 crossref_primary_10_1038_s41594_018_0134_5 crossref_primary_10_1126_science_abb0736 crossref_primary_10_1111_cge_12606 crossref_primary_10_1002_ggn2_10040 crossref_primary_10_1093_procel_pwac036 crossref_primary_10_1101_gad_349659_122 crossref_primary_10_1016_j_cels_2018_01_009 crossref_primary_10_1073_pnas_1821893117 crossref_primary_10_1016_j_jmb_2018_06_037 crossref_primary_10_1038_s41416_023_02522_5 crossref_primary_10_1016_j_yjmcc_2023_03_008 crossref_primary_10_1016_j_jmb_2018_06_034 crossref_primary_10_1038_s41467_017_01007_3 crossref_primary_10_3389_fgene_2019_00365 crossref_primary_10_1038_nrg_2015_17 crossref_primary_10_1007_s12257_019_0107_5 crossref_primary_10_1242_dev_186650 crossref_primary_10_1111_1744_7917_12634 crossref_primary_10_3390_bioengineering9100490 crossref_primary_10_1093_stcltm_szad019 crossref_primary_10_1016_j_cell_2018_03_052 crossref_primary_10_1016_j_xgen_2025_100878 crossref_primary_10_1038_s41587_019_0296_7 crossref_primary_10_1016_j_bcp_2021_114562 crossref_primary_10_3390_ijms222212178 crossref_primary_10_1002_1873_3468_12993 crossref_primary_10_1016_j_csbj_2022_09_012 crossref_primary_10_1016_j_chom_2017_08_004 crossref_primary_10_1038_s41467_021_21188_2 crossref_primary_10_1093_nar_gkad1216 crossref_primary_10_1002_1873_3468_14709 crossref_primary_10_3390_biom13121684 crossref_primary_10_1096_fj_202000171R crossref_primary_10_1016_j_bios_2018_09_035 crossref_primary_10_3389_fgeed_2023_1269115 crossref_primary_10_3389_fendo_2020_576632 crossref_primary_10_1002_smll_202102494 crossref_primary_10_2217_epi_2020_0110 crossref_primary_10_1089_crispr_2022_0011 crossref_primary_10_1111_jcmm_14470 crossref_primary_10_1038_nmeth_4466 crossref_primary_10_1126_science_abj4008 crossref_primary_10_1007_s41649_021_00167_1 crossref_primary_10_1016_j_cell_2018_03_068 crossref_primary_10_1089_scd_2019_0188 crossref_primary_10_1016_j_cels_2024_09_002 crossref_primary_10_1016_j_neuint_2021_105039 crossref_primary_10_1016_j_copbio_2017_06_001 crossref_primary_10_1093_nar_gkae1039 crossref_primary_10_1016_j_biotechadv_2021_107853 crossref_primary_10_1002_anie_201914575 crossref_primary_10_1038_s41467_024_54355_2 crossref_primary_10_1093_nar_gkad301 crossref_primary_10_1016_j_gene_2024_148670 crossref_primary_10_1038_nmeth_4430 crossref_primary_10_1093_bib_bbw052 crossref_primary_10_1016_j_canlet_2019_01_017 crossref_primary_10_1080_13102818_2021_1892524 crossref_primary_10_1186_s13059_023_03087_5 crossref_primary_10_1038_s41589_024_01655_9 crossref_primary_10_1371_journal_pone_0136064 crossref_primary_10_3109_10409238_2015_1117053 crossref_primary_10_1126_scitranslmed_adg7740 crossref_primary_10_1002_jcb_26111 crossref_primary_10_1074_jbc_REV119_005601 crossref_primary_10_1002_cbic_202100561 crossref_primary_10_1093_nar_gkac464 crossref_primary_10_3390_biomedicines10081842 crossref_primary_10_1093_nar_gkac463 crossref_primary_10_1186_s13287_019_1458_8 crossref_primary_10_1007_s13402_023_00847_0 crossref_primary_10_1038_s41467_023_36452_w crossref_primary_10_1016_j_bbrc_2023_02_061 crossref_primary_10_1016_j_molcel_2023_02_011 crossref_primary_10_1038_s41467_024_49678_z crossref_primary_10_1038_s41467_021_25991_9 crossref_primary_10_15252_msb_20177834 crossref_primary_10_1016_j_stem_2017_09_006 crossref_primary_10_1016_j_cellin_2022_100068 crossref_primary_10_1128_spectrum_05204_22 crossref_primary_10_1073_pnas_2003702117 crossref_primary_10_1038_s41588_025_02284_1 crossref_primary_10_1038_s44318_025_00502_4 crossref_primary_10_1126_science_aau0629 crossref_primary_10_1038_srep28566 crossref_primary_10_1016_j_jneumeth_2016_12_015 crossref_primary_10_1016_j_cell_2021_03_025 crossref_primary_10_1016_j_ccell_2019_12_007 crossref_primary_10_1038_nrc3950 crossref_primary_10_1134_S2079059717040116 crossref_primary_10_2147_JIR_S506760 crossref_primary_10_1038_nrmicro_2015_24 crossref_primary_10_1002_smtd_201900640 crossref_primary_10_1038_s41467_018_07901_8 crossref_primary_10_1016_j_cels_2017_08_011 crossref_primary_10_1038_s41598_020_74537_4 crossref_primary_10_1016_j_lfs_2024_123317 crossref_primary_10_1093_cvr_cvac191 crossref_primary_10_3892_mmr_2017_8099 crossref_primary_10_1371_journal_ppat_1013278 crossref_primary_10_1038_ncomms11707 crossref_primary_10_1038_s41398_023_02356_y crossref_primary_10_1155_2016_3582380 crossref_primary_10_1038_srep36199 crossref_primary_10_1038_s41419_021_03507_z crossref_primary_10_1089_crispr_2022_0001 crossref_primary_10_1074_jbc_M117_777722 crossref_primary_10_1038_s41596_021_00666_3 crossref_primary_10_1016_j_ymthe_2018_01_004 crossref_primary_10_1016_j_omtn_2018_12_003 crossref_primary_10_1002_biot_201500082 crossref_primary_10_1007_s00018_020_03695_5 crossref_primary_10_1016_j_nbt_2024_09_001 crossref_primary_10_1002_art_42703 crossref_primary_10_3390_cells10020260 crossref_primary_10_1016_j_stem_2016_01_024 crossref_primary_10_1080_1744666X_2017_1241711 crossref_primary_10_1002_hep4_1413 crossref_primary_10_1158_0008_5472_CAN_24_2938 crossref_primary_10_1007_s40572_022_00372_6 crossref_primary_10_1016_j_devcel_2020_11_002 crossref_primary_10_1002_mba2_70 crossref_primary_10_1093_nar_gkab174 crossref_primary_10_1128_jvi_00707_22 crossref_primary_10_1016_j_crmeth_2021_100082 crossref_primary_10_1016_j_ymeth_2020_04_006 crossref_primary_10_1038_s41467_019_13315_x crossref_primary_10_1096_fj_201901107RR crossref_primary_10_1016_j_micres_2020_126694 crossref_primary_10_1016_j_jgg_2016_03_001 crossref_primary_10_1093_nar_gkx993 crossref_primary_10_1016_j_omtn_2019_07_003 crossref_primary_10_1038_s41467_022_35580_z crossref_primary_10_1016_j_microc_2024_110581 crossref_primary_10_1038_s41421_022_00421_2 crossref_primary_10_1038_s41573_022_00476_6 crossref_primary_10_1093_nar_gkaf585 crossref_primary_10_1186_s12929_018_0425_5 crossref_primary_10_3390_ijms21020530 crossref_primary_10_3389_fgeed_2021_644319 crossref_primary_10_1186_s13619_025_00260_y crossref_primary_10_1093_nar_gkaa1000 crossref_primary_10_1182_blood_2021012806 crossref_primary_10_1038_s41419_022_04663_6 crossref_primary_10_1161_CIRCULATIONAHA_121_056850 crossref_primary_10_1016_j_bbrc_2020_04_040 crossref_primary_10_3389_fimmu_2020_02062 crossref_primary_10_3390_microorganisms8050784 crossref_primary_10_1016_j_ymthe_2019_11_029 crossref_primary_10_1016_j_devcel_2024_02_008 crossref_primary_10_1038_s41467_018_04901_6 crossref_primary_10_1002_jev2_70017 crossref_primary_10_1007_s13238_018_0552_5 crossref_primary_10_3390_ijms20184381 crossref_primary_10_1016_j_neo_2016_07_001 crossref_primary_10_3390_ijms22010397 crossref_primary_10_1016_j_jbiotec_2015_12_026 crossref_primary_10_1016_j_coviro_2018_03_007 crossref_primary_10_1016_j_omto_2023_100733 crossref_primary_10_1016_j_cell_2023_08_031 crossref_primary_10_2217_nnm_2022_0083 crossref_primary_10_1038_s12276_025_01514_0 crossref_primary_10_1155_2020_8857344 crossref_primary_10_1161_CIRCRESAHA_118_314522 crossref_primary_10_1016_j_ajhg_2022_07_003 crossref_primary_10_1016_j_bios_2021_113027 crossref_primary_10_1063_5_0167440 crossref_primary_10_1038_s41587_022_01255_9 crossref_primary_10_1016_j_cell_2024_01_042 crossref_primary_10_1016_j_gde_2018_05_001 crossref_primary_10_1038_s41467_017_01695_x crossref_primary_10_1038_s41587_024_02224_0 crossref_primary_10_1038_s41418_018_0192_6 crossref_primary_10_1093_infdis_jiz512 crossref_primary_10_1038_s41467_024_53736_x crossref_primary_10_1002_jcb_26198 crossref_primary_10_3892_ol_2017_5732 crossref_primary_10_1126_science_aax6648 crossref_primary_10_1186_s12943_024_01987_z crossref_primary_10_3389_fcell_2023_1295555 crossref_primary_10_1093_nar_gkad395 crossref_primary_10_1038_s41589_020_0483_3 crossref_primary_10_1038_s41592_023_02162_w crossref_primary_10_1126_scitranslmed_aaz8664 crossref_primary_10_1158_2767_9764_CRC_24_0416 crossref_primary_10_3389_fpls_2016_00703 crossref_primary_10_1016_j_coche_2016_12_002 crossref_primary_10_3389_fgene_2023_1147222 crossref_primary_10_1038_s41467_020_20165_5 crossref_primary_10_1093_protein_gzaf008 crossref_primary_10_1038_s41467_023_39337_0 crossref_primary_10_1371_journal_pone_0181902 crossref_primary_10_3390_antibiotics8010018 crossref_primary_10_1038_s41421_018_0069_3 crossref_primary_10_1038_s41583_019_0121_9 crossref_primary_10_1093_plcell_koaa029 crossref_primary_10_1007_s12250_020_00208_3 crossref_primary_10_3390_ijms20133168 crossref_primary_10_1016_j_ccell_2024_02_016 crossref_primary_10_1177_17534259231225611 crossref_primary_10_1186_s13059_020_01989_2 crossref_primary_10_1186_s13059_020_02137_6 crossref_primary_10_1186_s12943_025_02401_y crossref_primary_10_1016_j_gim_2024_101097 crossref_primary_10_1038_srep19675 crossref_primary_10_1016_j_molcel_2024_10_021 crossref_primary_10_1038_ncomms11786 crossref_primary_10_1186_s12864_018_4963_8 crossref_primary_10_1016_j_stem_2023_09_007 crossref_primary_10_1093_nar_gky890 crossref_primary_10_7554_eLife_19760 crossref_primary_10_1016_j_cell_2022_11_026 crossref_primary_10_1016_j_molcel_2023_04_012 crossref_primary_10_1038_s41467_019_14147_5 crossref_primary_10_1002_anie_202009062 crossref_primary_10_1111_febs_13251 crossref_primary_10_1136_jmedgenet_2015_103409 crossref_primary_10_1002_jcp_26141 crossref_primary_10_1016_j_pbiomolbio_2022_05_001 crossref_primary_10_1038_s41467_021_23316_4 crossref_primary_10_1002_advs_202001447 crossref_primary_10_1002_jcp_27476 crossref_primary_10_1038_s41418_020_0499_y crossref_primary_10_1038_s41467_022_33181_4 crossref_primary_10_1016_j_conb_2019_05_005 crossref_primary_10_1016_j_omtn_2016_11_004 crossref_primary_10_1155_2020_5425612 crossref_primary_10_1016_j_molcel_2020_06_012 crossref_primary_10_1111_febs_13248 crossref_primary_10_3390_ijms26010314 crossref_primary_10_1016_j_molcel_2020_06_014 crossref_primary_10_3390_toxins17040178 crossref_primary_10_1016_j_xplc_2025_101427 crossref_primary_10_1038_s41467_024_55134_9 crossref_primary_10_1016_j_cr_2019_08_001 crossref_primary_10_1016_j_omtn_2017_04_001 crossref_primary_10_1111_jipb_12734 crossref_primary_10_1089_crispr_2018_0009 crossref_primary_10_1038_s41598_017_07827_z crossref_primary_10_1007_s13534_021_00199_4 crossref_primary_10_1038_s41467_025_60001_2 crossref_primary_10_1089_crispr_2018_0012 crossref_primary_10_1038_s41587_024_02442_6 crossref_primary_10_1080_08923973_2018_1437625 crossref_primary_10_1016_j_conb_2019_03_010 crossref_primary_10_1038_s41467_017_00530_7 crossref_primary_10_1136_gutjnl_2023_330414 crossref_primary_10_1007_s00299_016_1987_x crossref_primary_10_1016_j_coisb_2017_08_002 crossref_primary_10_3390_ijms24054778 crossref_primary_10_1186_s40643_022_00614_3 crossref_primary_10_1007_s00299_023_03072_z crossref_primary_10_1021_jacs_9b11638 crossref_primary_10_3390_v13071373 crossref_primary_10_1016_j_jcmgh_2025_101460 crossref_primary_10_1139_gen_2020_0104 crossref_primary_10_1186_s13059_017_1318_8 crossref_primary_10_3390_vaccines5040037 crossref_primary_10_1016_j_virusres_2017_07_020 crossref_primary_10_1038_s41388_023_02929_7 crossref_primary_10_1038_s41596_021_00595_1 crossref_primary_10_1080_15384101_2019_1656019 crossref_primary_10_1111_jcmm_14916 crossref_primary_10_1016_j_ijbiomac_2024_130413 crossref_primary_10_1038_nature23451 crossref_primary_10_3389_fgene_2024_1309175 crossref_primary_10_1038_s42003_021_01747_5 crossref_primary_10_1089_crispr_2018_0026 crossref_primary_10_1038_s41590_019_0500_4 crossref_primary_10_1038_s41467_025_62818_3 crossref_primary_10_1038_s41467_022_29120_y crossref_primary_10_1016_j_jid_2016_06_007 crossref_primary_10_1038_s41598_023_49284_x crossref_primary_10_1016_j_semcdb_2019_04_018 crossref_primary_10_1007_s12195_025_00843_4 crossref_primary_10_1016_j_omtm_2019_12_010 crossref_primary_10_1002_adbi_201800132 crossref_primary_10_1038_s41467_025_63570_4 crossref_primary_10_1155_2018_7834175 crossref_primary_10_3390_bioengineering10080884 crossref_primary_10_1016_j_jbiotec_2018_10_011 crossref_primary_10_1002_biot_201500027 crossref_primary_10_1038_s41592_021_01207_2 crossref_primary_10_1016_j_ijbiomac_2020_07_039 crossref_primary_10_1016_j_canlet_2016_01_030 crossref_primary_10_1016_j_preteyeres_2016_05_001 crossref_primary_10_1158_0008_5472_CAN_19_0244 crossref_primary_10_1126_scitranslmed_aai9118 crossref_primary_10_3389_fonc_2022_891652 crossref_primary_10_1038_s41581_022_00636_2 crossref_primary_10_1073_pnas_1802448115 crossref_primary_10_1002_jev2_70071 crossref_primary_10_1038_srep18759 crossref_primary_10_1038_nrm_2015_2 crossref_primary_10_1016_j_ebiom_2020_102667 crossref_primary_10_1016_j_bbcan_2016_09_002 crossref_primary_10_1016_j_semcdb_2019_05_007 crossref_primary_10_1002_jcp_30260 crossref_primary_10_1371_journal_ppat_1010464 crossref_primary_10_1146_annurev_immunol_042718_041522 crossref_primary_10_1080_14728222_2020_1820986 crossref_primary_10_1007_s11033_022_07880_6 crossref_primary_10_1016_j_jconrel_2016_02_002 crossref_primary_10_1016_j_ccell_2019_01_019 crossref_primary_10_1016_j_bbcan_2016_03_005 crossref_primary_10_7554_eLife_77825 crossref_primary_10_1016_j_ymben_2022_10_005 crossref_primary_10_1073_pnas_1805784115 crossref_primary_10_3390_biomedicines11010101 crossref_primary_10_1038_s41388_025_03273_8 crossref_primary_10_1016_j_semcdb_2019_05_013 crossref_primary_10_1038_s41392_024_01754_y crossref_primary_10_1038_s41467_020_14362_5 crossref_primary_10_1038_nrd_2016_238 crossref_primary_10_1007_s11248_018_0096_8 crossref_primary_10_1038_s41467_020_14397_8 crossref_primary_10_1186_s12943_021_01431_6 crossref_primary_10_1038_mt_2016_7 crossref_primary_10_3233_JAD_180422 crossref_primary_10_1038_s41467_019_11371_x crossref_primary_10_1016_j_ejca_2018_01_002 crossref_primary_10_1155_2021_3829286 crossref_primary_10_1038_s41467_021_22490_9 crossref_primary_10_1002_hep_30102 crossref_primary_10_1002_eji_201444558 crossref_primary_10_1038_mt_2015_202 crossref_primary_10_1002_anie_201606123 crossref_primary_10_1038_mt_2015_200 crossref_primary_10_1007_s00018_025_05786_7 crossref_primary_10_1101_gr_190983_115 crossref_primary_10_1093_hmg_ddac193 crossref_primary_10_1186_s13073_019_0665_3 crossref_primary_10_7554_eLife_53839 crossref_primary_10_1093_hmg_ddac194 crossref_primary_10_1016_j_pbi_2020_101980 crossref_primary_10_1038_ncomms14422 crossref_primary_10_1038_s41467_020_15053_x crossref_primary_10_1016_j_intimp_2024_112730 crossref_primary_10_1089_crispr_2024_0013 crossref_primary_10_1002_adfm_202402630 crossref_primary_10_1021_acssynbio_5c00170 crossref_primary_10_1016_j_molmed_2017_08_002 crossref_primary_10_3390_molecules27196266 crossref_primary_10_1038_s41467_022_32628_y crossref_primary_10_1002_cplu_202000785 crossref_primary_10_1038_nbt_3526 crossref_primary_10_3389_fimmu_2024_1426682 crossref_primary_10_3389_fpls_2023_1157678 crossref_primary_10_1186_s13148_023_01482_0 crossref_primary_10_1186_s40364_021_00297_6 crossref_primary_10_1186_s13073_022_01134_7 crossref_primary_10_3390_ijms242317029 crossref_primary_10_1016_j_xgen_2025_100982 crossref_primary_10_1038_s41467_018_04899_x crossref_primary_10_1016_j_pt_2016_04_013 crossref_primary_10_1089_omi_2015_0023 crossref_primary_10_3389_fimmu_2017_01616 crossref_primary_10_1038_srep26857 crossref_primary_10_1016_j_conb_2017_03_010 crossref_primary_10_1186_s13024_019_0343_3 crossref_primary_10_1016_j_jtice_2025_106304 crossref_primary_10_1002_JLB_3MR0717_307R crossref_primary_10_1038_s41587_023_01748_1 crossref_primary_10_1016_j_slast_2024_100121 crossref_primary_10_1038_s41467_024_54824_8 crossref_primary_10_1016_j_ymben_2022_01_003 crossref_primary_10_1038_s41467_018_05773_6 crossref_primary_10_7554_eLife_60583 crossref_primary_10_1002_jcb_26406 crossref_primary_10_1093_g3journal_jkac301 crossref_primary_10_1038_nchembio_1963 crossref_primary_10_1096_fj_201700485rr crossref_primary_10_1016_j_molcel_2016_07_004 crossref_primary_10_1038_s41419_019_2155_3 crossref_primary_10_1146_annurev_pharmtox_033123_123610 crossref_primary_10_1016_j_virusres_2020_198260 crossref_primary_10_3390_ijms22137177 crossref_primary_10_4252_wjsc_v11_i11_937 crossref_primary_10_1016_j_molcel_2020_01_016 crossref_primary_10_1016_j_xgen_2025_100927 crossref_primary_10_1186_s12951_023_01952_w crossref_primary_10_3390_cells11050806 crossref_primary_10_3390_ijms24010397 crossref_primary_10_1152_physrev_00036_2015 crossref_primary_10_3389_fimmu_2022_1041451 crossref_primary_10_3390_ijms23158750 crossref_primary_10_3390_ijms23136964 crossref_primary_10_1002_bab_1901 crossref_primary_10_1038_s41582_020_0373_z crossref_primary_10_3389_frsus_2024_1378712 crossref_primary_10_1038_s41467_022_32485_9 crossref_primary_10_1038_s41467_019_12543_5 crossref_primary_10_1038_s41467_022_32023_7 crossref_primary_10_1093_plphys_kiae149 crossref_primary_10_1002_anie_201601708 crossref_primary_10_1038_ncomms12284 crossref_primary_10_1038_s41467_024_47633_6 crossref_primary_10_1158_0008_5472_CAN_16_1267_T crossref_primary_10_1038_ncomms15315 crossref_primary_10_3389_fgene_2018_00640 crossref_primary_10_1038_s41467_023_37829_7 crossref_primary_10_1007_s12275_022_00005_5 crossref_primary_10_1111_apha_14271 crossref_primary_10_3389_fnins_2022_924917 crossref_primary_10_3389_fbioe_2020_00882 crossref_primary_10_1038_nmeth_3871 crossref_primary_10_1016_j_tcb_2016_08_004 crossref_primary_10_1038_s41556_019_0409_z crossref_primary_10_1016_j_cels_2019_10_003 crossref_primary_10_1002_ange_201806941 crossref_primary_10_1016_j_mocell_2024_100092 crossref_primary_10_3389_fpls_2023_1146922 crossref_primary_10_1073_pnas_1800677115 crossref_primary_10_1002_advs_202501663 crossref_primary_10_1038_s41592_023_02038_z crossref_primary_10_3389_fgeed_2022_846669 crossref_primary_10_3389_fgeed_2025_1602983 crossref_primary_10_1016_j_jbc_2021_101088 crossref_primary_10_1186_s12943_024_02033_8 crossref_primary_10_1038_s44318_024_00188_0 crossref_primary_10_1038_ncomms15334 crossref_primary_10_1111_ahg_12271 crossref_primary_10_1177_15330338231165125 crossref_primary_10_1098_rsob_180013 crossref_primary_10_1007_s00204_017_2135_2 crossref_primary_10_1016_j_pbi_2016_11_011 crossref_primary_10_1016_j_coisb_2017_05_008 crossref_primary_10_1016_j_ymben_2022_12_004 crossref_primary_10_3389_fncel_2023_1237641 crossref_primary_10_3390_ijms20236041 crossref_primary_10_3390_plants11010051 crossref_primary_10_1038_nmeth_3452 crossref_primary_10_1038_emm_2016_111 crossref_primary_10_1016_j_tig_2018_06_002 crossref_primary_10_3389_fncir_2017_00076 crossref_primary_10_1002_advs_202300656 crossref_primary_10_1038_s41598_019_50588_0 crossref_primary_10_1186_s13059_020_02044_w crossref_primary_10_3390_ijms23158714 crossref_primary_10_1016_j_cobme_2023_100479 crossref_primary_10_1101_gr_208926_116 crossref_primary_10_3389_fmolb_2023_1110445 crossref_primary_10_1039_D1NR04430C crossref_primary_10_1002_pros_24251 crossref_primary_10_1242_dev_160333 crossref_primary_10_1016_j_addr_2021_114042 crossref_primary_10_3892_ijo_2018_4434 crossref_primary_10_1016_j_neuron_2023_04_021 crossref_primary_10_1038_s43018_024_00784_3 crossref_primary_10_1002_anie_201609229 crossref_primary_10_1007_s13258_021_01199_5 crossref_primary_10_1158_1541_7786_MCR_20_0262 crossref_primary_10_1016_j_omtn_2020_04_005 crossref_primary_10_1038_s41598_018_28653_x crossref_primary_10_3389_fcell_2021_730014 crossref_primary_10_1038_s41576_021_00409_w crossref_primary_10_1016_j_ymthe_2018_08_019 crossref_primary_10_1038_nmeth_3433 crossref_primary_10_1016_j_drudis_2018_01_014 crossref_primary_10_1093_nar_gkab211 crossref_primary_10_1111_cpr_70099 crossref_primary_10_1007_s13238_016_0360_8 crossref_primary_10_1038_s41580_021_00335_z crossref_primary_10_1126_science_aay0939 crossref_primary_10_1016_j_saa_2023_123121 crossref_primary_10_1038_s41467_021_25684_3 crossref_primary_10_3390_v16020297 crossref_primary_10_1186_s13059_015_0794_y crossref_primary_10_2147_IJN_S455574 crossref_primary_10_26508_lsa_202402715 crossref_primary_10_1038_s41375_021_01409_9 crossref_primary_10_3390_cells9081888 crossref_primary_10_1016_j_mcp_2018_03_006 crossref_primary_10_1038_s41378_019_0112_z crossref_primary_10_1093_nar_gkaf620 crossref_primary_10_1002_biot_202100239 crossref_primary_10_1007_s00294_018_0887_8 crossref_primary_10_1016_j_mib_2017_08_002 crossref_primary_10_1021_jacs_2c09129 crossref_primary_10_1038_s41587_022_01444_6 crossref_primary_10_1016_j_ymthe_2019_01_014 crossref_primary_10_1016_j_jconrel_2016_11_014 crossref_primary_10_1038_nn_4362 crossref_primary_10_1016_j_ymthe_2021_10_015 crossref_primary_10_1038_s41580_019_0131_5 crossref_primary_10_1038_s41588_021_00829_8 crossref_primary_10_1080_21541264_2019_1695492 crossref_primary_10_1007_s10577_022_09706_4 crossref_primary_10_1371_journal_pone_0154604 crossref_primary_10_1016_j_arr_2024_102327 crossref_primary_10_1164_rccm_201807_1239ED crossref_primary_10_1016_j_xpro_2024_103306 crossref_primary_10_1126_science_aav6872 crossref_primary_10_1016_j_apsb_2025_05_007 crossref_primary_10_1038_s41467_022_33287_9 crossref_primary_10_1053_j_ajkd_2018_02_347 crossref_primary_10_1016_j_biotechadv_2019_107447 crossref_primary_10_1016_j_intimp_2020_107071 crossref_primary_10_1186_s12864_017_4285_2 crossref_primary_10_1016_j_molcel_2016_12_023 crossref_primary_10_1002_smll_201907301 crossref_primary_10_1016_j_gde_2020_12_005 crossref_primary_10_1016_j_cell_2019_04_009 crossref_primary_10_1534_genetics_115_184879 crossref_primary_10_1158_1078_0432_CCR_17_1455 crossref_primary_10_1016_j_trecan_2025_08_001 crossref_primary_10_1038_s41392_021_00645_w crossref_primary_10_1371_journal_pone_0198714 crossref_primary_10_1089_nat_2015_0545 crossref_primary_10_1016_j_ijbiomac_2023_123262 crossref_primary_10_1016_j_copbio_2018_08_008 crossref_primary_10_3389_fmolb_2022_1070526 crossref_primary_10_1007_s11481_019_09878_7 crossref_primary_10_1002_advs_201700964 crossref_primary_10_1038_s41556_022_01008_5 crossref_primary_10_1038_s41467_023_40836_3 crossref_primary_10_1186_s12711_021_00662_x crossref_primary_10_1016_j_cobme_2018_08_001 crossref_primary_10_1016_j_tplants_2019_09_006 crossref_primary_10_1002_ctm2_835 crossref_primary_10_1016_j_cels_2016_12_011 crossref_primary_10_1038_s41598_019_56670_x crossref_primary_10_1016_j_bbcan_2024_189212 crossref_primary_10_1093_nar_gkac582 crossref_primary_10_1016_j_gene_2017_11_033 crossref_primary_10_1080_15384101_2023_2299624 crossref_primary_10_1128_JVI_01002_20 crossref_primary_10_3390_ani15010019 crossref_primary_10_1007_s12195_019_00606_y crossref_primary_10_26508_lsa_202201404 crossref_primary_10_1038_s41467_019_13403_y crossref_primary_10_1016_j_omtn_2020_02_009 crossref_primary_10_3389_fgene_2015_00362 crossref_primary_10_1002_cbic_201800823 crossref_primary_10_3389_fgene_2023_1273994 crossref_primary_10_3390_ijms161023143 crossref_primary_10_1016_j_preteyeres_2024_101289 crossref_primary_10_1038_nbt_3199 crossref_primary_10_3390_genes14040906 crossref_primary_10_1515_hsz_2023_0174 crossref_primary_10_1161_JAHA_121_024561 crossref_primary_10_1038_s41467_017_01650_w crossref_primary_10_1126_science_abb6896 crossref_primary_10_1371_journal_pone_0158294 crossref_primary_10_1016_j_omtm_2021_04_009 crossref_primary_10_1038_s41467_025_61788_w crossref_primary_10_1016_j_csbj_2020_08_009 crossref_primary_10_1016_j_ymben_2021_04_002 crossref_primary_10_3390_ph14080765 crossref_primary_10_1002_jgm_3377 crossref_primary_10_1111_febs_13777 crossref_primary_10_1155_2018_3797214 crossref_primary_10_1016_j_clim_2018_02_001 crossref_primary_10_3390_molecules24234229 crossref_primary_10_1128_IAI_00916_19 crossref_primary_10_1111_febs_13770 crossref_primary_10_1038_celldisc_2016_9 crossref_primary_10_1038_nprot_2017_016 crossref_primary_10_1093_nar_gkad458 crossref_primary_10_1093_nar_gky904 crossref_primary_10_1111_febs_13768 crossref_primary_10_1158_2159_8290_CD_19_1128 crossref_primary_10_1016_j_cell_2016_08_056 crossref_primary_10_1002_advs_202003902 crossref_primary_10_1186_s13578_025_01397_8 crossref_primary_10_1128_mSphere_00002_19 crossref_primary_10_3390_cells12192344 crossref_primary_10_1016_j_ymthe_2019_03_017 crossref_primary_10_1038_s41467_020_15454_y crossref_primary_10_1016_j_cell_2017_10_025 crossref_primary_10_1093_nar_gkae798 crossref_primary_10_3389_fpls_2023_1171154 crossref_primary_10_1038_s41467_018_05373_4 crossref_primary_10_3389_fcell_2019_00013 crossref_primary_10_1016_j_heliyon_2024_e38588 crossref_primary_10_1038_nbt_4062 crossref_primary_10_1016_j_neures_2018_07_003 crossref_primary_10_1038_s41467_019_11562_6 crossref_primary_10_1038_s41467_019_13621_4 crossref_primary_10_1038_s41477_019_0461_5 crossref_primary_10_1126_science_aau7187 crossref_primary_10_1016_j_molcel_2020_12_003 crossref_primary_10_1111_febs_13750 crossref_primary_10_1038_s41467_021_27722_6 crossref_primary_10_1038_s41588_019_0479_7 crossref_primary_10_1016_j_biomaterials_2021_121229 crossref_primary_10_1016_j_molmed_2015_07_006 crossref_primary_10_1016_j_omtn_2024_102256 crossref_primary_10_1016_j_ejphar_2019_04_042 crossref_primary_10_1097_HEP_0000000000000578 crossref_primary_10_1016_j_molcel_2021_07_034 crossref_primary_10_15252_embj_201797138 crossref_primary_10_1007_s13311_021_01081_y crossref_primary_10_15252_embj_2022112259 crossref_primary_10_1146_annurev_cancerbio_062624_104149 crossref_primary_10_1038_s41467_019_11955_7 crossref_primary_10_7554_eLife_94884 crossref_primary_10_1016_j_omtn_2022_07_013 crossref_primary_10_3390_ijms160922151 crossref_primary_10_1186_s13059_015_0808_9 crossref_primary_10_1016_j_rhum_2016_07_021 crossref_primary_10_1038_s41467_025_62343_3 crossref_primary_10_1038_nbt_3149 crossref_primary_10_1016_j_omtn_2021_12_033 crossref_primary_10_1093_nar_gkaf235 crossref_primary_10_1016_j_celrep_2019_04_028 crossref_primary_10_1002_advs_202306059 crossref_primary_10_1016_j_stem_2020_01_004 crossref_primary_10_1038_s41596_018_0113_7 crossref_primary_10_1146_annurev_bioeng_071516_044649 crossref_primary_10_1016_j_kint_2017_01_037 crossref_primary_10_3390_biomedicines11072054 crossref_primary_10_1016_j_jgg_2020_11_001 crossref_primary_10_1038_s41598_019_40003_z crossref_primary_10_1016_j_engmed_2024_100035 crossref_primary_10_1038_s41588_022_01131_x crossref_primary_10_1038_s41598_018_31433_2 crossref_primary_10_3390_cells9040993 crossref_primary_10_1007_s12264_020_00607_2 crossref_primary_10_1080_14737159_2024_2388777 crossref_primary_10_1038_s41467_017_00644_y crossref_primary_10_1080_22221751_2022_2140605 crossref_primary_10_3389_fgene_2015_00300 crossref_primary_10_1016_j_scib_2019_07_035 crossref_primary_10_1002_jcb_30578 crossref_primary_10_1038_s41589_019_0338_y crossref_primary_10_1002_cti2_1286 crossref_primary_10_1186_s13100_024_00313_0 crossref_primary_10_1016_j_semcancer_2023_10_002 crossref_primary_10_3389_fphar_2023_1284610 crossref_primary_10_2144_fsoa_2023_0257 crossref_primary_10_1038_nmeth_4286 crossref_primary_10_3390_cancers13071591 crossref_primary_10_1038_s41467_025_55957_0 crossref_primary_10_1038_s41568_024_00763_x crossref_primary_10_1016_j_jgg_2015_02_007 crossref_primary_10_1016_j_cels_2020_06_004 crossref_primary_10_1172_JCI90253 crossref_primary_10_1002_hep_29626 crossref_primary_10_1007_s10142_025_01623_z crossref_primary_10_1186_s13059_015_0843_6 crossref_primary_10_3390_biology10060530 crossref_primary_10_1016_j_jgg_2017_09_005 crossref_primary_10_1002_jcp_29324 crossref_primary_10_1002_advs_201902312 crossref_primary_10_1016_j_biortech_2020_124624 crossref_primary_10_1186_s12943_024_02029_4 crossref_primary_10_3390_cells9061447 crossref_primary_10_1124_dmd_121_000649 crossref_primary_10_1007_s10529_018_2608_2 crossref_primary_10_1093_hr_uhac148 crossref_primary_10_1371_journal_pgen_1009729 crossref_primary_10_1038_s10038_017_0376_9 crossref_primary_10_1007_s40142_021_00198_y crossref_primary_10_1016_j_biotechadv_2017_11_008 crossref_primary_10_1016_j_trac_2025_118297 crossref_primary_10_1002_eji_202048712 crossref_primary_10_1016_j_molcel_2018_04_023 crossref_primary_10_3389_fpls_2024_1279738 crossref_primary_10_1038_s41467_021_22932_4 crossref_primary_10_1186_s12920_018_0394_2 crossref_primary_10_1038_s41593_025_02040_y crossref_primary_10_1021_jacs_0c08996 crossref_primary_10_1158_0008_5472_CAN_24_0013 crossref_primary_10_1016_j_ymthe_2024_10_029 crossref_primary_10_1038_srep16277 crossref_primary_10_1111_jipb_13953 crossref_primary_10_3390_vetsci9040166 crossref_primary_10_1016_j_ab_2016_05_014 crossref_primary_10_1038_s41388_022_02417_4 crossref_primary_10_3390_biology10101038 crossref_primary_10_3390_epigenomes3030020 crossref_primary_10_1016_j_ibmb_2019_04_013 crossref_primary_10_1186_s13059_020_1939_1 crossref_primary_10_1016_j_cmet_2021_11_011 crossref_primary_10_1186_s13059_016_0900_9 crossref_primary_10_1016_j_cell_2016_04_003 crossref_primary_10_3390_cancers12113220 crossref_primary_10_1038_s41587_020_0412_8 crossref_primary_10_3390_biomedicines6040105 crossref_primary_10_1186_s12862_017_1036_6 crossref_primary_10_1007_s10529_022_03247_w crossref_primary_10_1007_s12268_016_0659_2 crossref_primary_10_1007_s13238_016_0368_0 crossref_primary_10_1016_j_csbj_2022_11_034 crossref_primary_10_1038_s41467_024_52490_4 crossref_primary_10_3390_ijms25042243 crossref_primary_10_3390_pharmaceutics12080759 crossref_primary_10_1038_s41592_020_01053_8 crossref_primary_10_1007_s12257_022_0348_6 crossref_primary_10_1111_pbi_70137 crossref_primary_10_1002_j_2040_4603_2019_tb00075_x crossref_primary_10_7554_eLife_83342 crossref_primary_10_1016_j_molimm_2017_12_005 crossref_primary_10_1111_resp_13527 crossref_primary_10_1016_j_omtm_2023_03_006 crossref_primary_10_3389_fpls_2020_00509 crossref_primary_10_1002_hep_29683 crossref_primary_10_1007_s13238_015_0169_x crossref_primary_10_1016_j_bbrc_2016_02_113 crossref_primary_10_3389_fcimb_2019_00069 crossref_primary_10_1016_j_toxlet_2017_08_079 crossref_primary_10_1371_journal_pone_0270008 crossref_primary_10_1093_nar_gkz425 crossref_primary_10_1136_jitc_2024_010145 crossref_primary_10_3390_cancers13215351 crossref_primary_10_4049_jimmunol_2100917 crossref_primary_10_3390_ijms25010658 crossref_primary_10_1016_j_canlet_2018_11_025 crossref_primary_10_1016_j_molp_2018_05_008 crossref_primary_10_1186_s12915_020_00911_3 crossref_primary_10_1038_s41596_023_00920_w crossref_primary_10_1089_hum_2020_241 crossref_primary_10_1016_j_tig_2017_07_006 crossref_primary_10_1016_j_jvir_2018_02_027 crossref_primary_10_1038_s41580_023_00697_6 crossref_primary_10_1093_bib_bbad131 crossref_primary_10_1186_s12943_022_01552_6 crossref_primary_10_7554_eLife_85542 crossref_primary_10_7554_eLife_87722 crossref_primary_10_1016_j_biocel_2022_106348 crossref_primary_10_1038_s41570_017_0078 crossref_primary_10_1111_pbi_13138 crossref_primary_10_1016_j_jve_2025_100597 crossref_primary_10_1016_j_ydbio_2021_01_003 crossref_primary_10_1021_envhealth_5c00072 crossref_primary_10_1016_j_chom_2023_05_018 crossref_primary_10_1186_s13059_019_1628_0 crossref_primary_10_1186_s13578_015_0027_9 crossref_primary_10_1002_biot_201700211 crossref_primary_10_1534_genetics_119_302964 crossref_primary_10_1038_s41587_020_0456_9 crossref_primary_10_1016_j_celrep_2024_114350 crossref_primary_10_1007_s40291_023_00642_5 crossref_primary_10_1016_j_ymben_2025_08_007 crossref_primary_10_1016_j_cellimm_2021_104436 crossref_primary_10_1016_j_tips_2021_10_012 crossref_primary_10_1089_crispr_2021_0063 crossref_primary_10_1038_s41589_019_0443_y crossref_primary_10_1016_j_gde_2019_03_003 crossref_primary_10_1016_j_tibtech_2015_12_014 crossref_primary_10_3390_cancers11091335 crossref_primary_10_1016_j_ccell_2020_04_006 crossref_primary_10_1093_nar_gkw066 crossref_primary_10_1126_scitranslmed_adp1720 crossref_primary_10_3390_cancers14153612 crossref_primary_10_1016_j_cmet_2022_02_009 crossref_primary_10_3389_fphar_2020_00119 crossref_primary_10_3389_fpls_2020_01254 crossref_primary_10_1016_j_molp_2017_11_010 crossref_primary_10_1158_0008_5472_CAN_21_4009 crossref_primary_10_1146_annurev_biodatasci_020520_113523 crossref_primary_10_1128_iai_00510_24 crossref_primary_10_1038_s41551_024_01278_4 crossref_primary_10_1038_s41556_020_00620_7 crossref_primary_10_1158_0008_5472_CAN_15_1248 crossref_primary_10_3390_epigenomes5030017 crossref_primary_10_1016_j_tibtech_2015_12_001 crossref_primary_10_1177_0022034516685045 crossref_primary_10_1093_plcell_koab099 crossref_primary_10_1016_j_nbd_2020_104954 crossref_primary_10_1172_JCI149526 crossref_primary_10_1242_jcs_245043 crossref_primary_10_1038_s41586_018_0393_7 crossref_primary_10_1371_journal_pone_0179410 crossref_primary_10_1016_j_critrevonc_2024_104287 crossref_primary_10_3390_ncrna8030032 crossref_primary_10_1038_nmeth_3733 crossref_primary_10_1038_s41571_019_0166_8 crossref_primary_10_1002_cptc_202100110 crossref_primary_10_1038_nbt_3863 crossref_primary_10_1038_s41418_021_00883_z crossref_primary_10_3390_ijms232012375 crossref_primary_10_1016_j_mcp_2024_102004 crossref_primary_10_1093_nar_gkaa865 crossref_primary_10_1186_s13059_020_01995_4 crossref_primary_10_1016_j_cell_2025_06_026 crossref_primary_10_3390_genes12111790 crossref_primary_10_1016_j_omtn_2022_03_020 crossref_primary_10_1002_hep_32417 crossref_primary_10_1073_pnas_1600582113 crossref_primary_10_1186_s12967_023_03967_1 crossref_primary_10_1124_mol_119_116897 crossref_primary_10_1002_anie_201806941 crossref_primary_10_1002_ange_202009062 crossref_primary_10_1093_plphys_kiac033 crossref_primary_10_1186_s13045_019_0719_4 crossref_primary_10_1039_C8IB00109J crossref_primary_10_1007_s12185_016_2017_z crossref_primary_10_15252_emmm_202012188 crossref_primary_10_1016_j_jgg_2019_11_002 crossref_primary_10_1016_j_lfs_2020_118525 crossref_primary_10_1016_j_nbt_2023_11_003 crossref_primary_10_1002_ange_201709201 crossref_primary_10_1055_s_0044_1785234 crossref_primary_10_1186_s13068_017_0957_z crossref_primary_10_1016_j_ymthe_2019_08_018 crossref_primary_10_1042_BST20200020 crossref_primary_10_1016_j_ab_2016_10_018 crossref_primary_10_1016_j_pharmthera_2020_107603 crossref_primary_10_1093_nar_gkz134 crossref_primary_10_1016_j_molcel_2017_09_029 crossref_primary_10_1038_s41598_022_12659_7 crossref_primary_10_1186_s13059_021_02321_2 crossref_primary_10_3389_fbioe_2022_1035543 crossref_primary_10_1016_j_omtm_2024_101203 crossref_primary_10_1093_biolre_ioz088 crossref_primary_10_1111_pbi_13635 crossref_primary_10_1093_biolre_ioz087 crossref_primary_10_1016_j_freeradbiomed_2016_08_003 crossref_primary_10_1016_j_copbio_2018_02_004 crossref_primary_10_1016_j_omtn_2022_01_005 crossref_primary_10_1007_s12031_017_0918_9 crossref_primary_10_3389_fgeed_2025_1565387 crossref_primary_10_1038_s41388_022_02372_0 crossref_primary_10_1016_j_molcel_2017_09_017 crossref_primary_10_1002_advs_202417478 crossref_primary_10_1016_j_molcel_2017_09_014 crossref_primary_10_1093_nar_gkaa425 crossref_primary_10_1038_s41419_022_05285_8 crossref_primary_10_29296_24999490_2025_02_03 crossref_primary_10_1038_s41419_023_05683_6 crossref_primary_10_1038_s41551_018_0215_0 crossref_primary_10_3390_ijms26136364 crossref_primary_10_1016_j_jgeb_2024_100427 crossref_primary_10_1038_s41588_020_0578_5 crossref_primary_10_3389_fgene_2018_00524 crossref_primary_10_1038_nbt_3853 crossref_primary_10_1016_j_omtn_2018_09_006 crossref_primary_10_1016_j_immuni_2015_05_004 crossref_primary_10_1093_glycob_cwy096 crossref_primary_10_1016_j_cels_2020_11_002 crossref_primary_10_1038_s41592_025_02652_z crossref_primary_10_1016_j_ccr_2023_215172 crossref_primary_10_1098_rsob_170121 crossref_primary_10_1111_jipb_13063 crossref_primary_10_3390_ijms222212322 crossref_primary_10_1186_s13059_018_1425_1 crossref_primary_10_1016_j_ymeth_2017_03_008 crossref_primary_10_1016_j_ymeth_2017_03_009 crossref_primary_10_1002_jcb_27609 crossref_primary_10_1016_j_stem_2016_04_013 crossref_primary_10_1016_j_ymeth_2017_03_007 crossref_primary_10_1016_j_biomaterials_2018_04_031 crossref_primary_10_1038_s41467_020_16880_8 crossref_primary_10_1371_journal_pone_0222778 crossref_primary_10_3390_ijms21249442 crossref_primary_10_1093_nar_gkw908 crossref_primary_10_1038_s41593_018_0077_5 crossref_primary_10_1038_s42003_023_05686_1 crossref_primary_10_3390_ijms241713447 crossref_primary_10_3390_cancers12102801 crossref_primary_10_1002_ggn2_202200014 crossref_primary_10_1016_j_omtn_2021_06_026 crossref_primary_10_32604_biocell_2022_021107 crossref_primary_10_1038_nmeth_3325 crossref_primary_10_1080_10409238_2024_2320659 crossref_primary_10_1016_j_tig_2025_06_003 crossref_primary_10_1089_crispr_2019_0077 crossref_primary_10_1093_narmme_ugaf001 crossref_primary_10_1161_CIRCRESAHA_118_313447 crossref_primary_10_1038_s41467_024_54477_7 crossref_primary_10_1073_pnas_1520110112 crossref_primary_10_1080_17425247_2023_2200246 crossref_primary_10_1080_10717544_2020_1850917 crossref_primary_10_1186_s12934_018_0867_1 crossref_primary_10_1038_s41467_024_50515_6 crossref_primary_10_1016_j_ymben_2015_12_003 crossref_primary_10_1038_s41467_024_51579_0 crossref_primary_10_1080_17460441_2017_1317244 crossref_primary_10_1038_s41598_024_80266_9 crossref_primary_10_1016_j_ymthe_2025_03_026 crossref_primary_10_1134_S0006297920110036 crossref_primary_10_1093_nar_gkac680 crossref_primary_10_1111_pbi_12755 crossref_primary_10_1128_AEM_01159_16 crossref_primary_10_1261_rna_078693_121 crossref_primary_10_3390_ijms24108468 crossref_primary_10_3390_ijms242216077 crossref_primary_10_1186_s13046_019_1322_9 crossref_primary_10_1038_cr_2016_3 crossref_primary_10_1016_j_biotechadv_2022_107935 crossref_primary_10_7554_eLife_60645 crossref_primary_10_1080_15592294_2021_1939477 crossref_primary_10_7554_eLife_94884_3 crossref_primary_10_1093_lifemedi_lnae031 crossref_primary_10_1007_s00253_016_7376_0 crossref_primary_10_1038_s41467_024_49926_2 crossref_primary_10_1186_s13287_024_03831_z crossref_primary_10_1007_s12033_020_00258_8 crossref_primary_10_1111_pcmr_12573 crossref_primary_10_1038_s41592_019_0436_5 crossref_primary_10_1128_spectrum_03846_23 crossref_primary_10_1002_ange_201606123 crossref_primary_10_1093_nar_gkw1326 crossref_primary_10_1038_nmeth_3312 crossref_primary_10_1080_07388551_2017_1312270 crossref_primary_10_1089_crispr_2019_0064 crossref_primary_10_1371_journal_pcbi_1008194 crossref_primary_10_3389_fbioe_2025_1562412 crossref_primary_10_1016_j_ijpara_2018_09_005 crossref_primary_10_1111_1759_7714_13485 crossref_primary_10_1111_jipb_13023 crossref_primary_10_1093_nar_gkad558 crossref_primary_10_1158_2326_6066_CIR_18_0272 crossref_primary_10_1038_s41598_025_86694_5 crossref_primary_10_1002_advs_201700611 crossref_primary_10_1038_s41598_017_16947_5 crossref_primary_10_1038_nrg3899 crossref_primary_10_1080_2162402X_2018_1494110 crossref_primary_10_3389_fonc_2020_00442 crossref_primary_10_1002_jgm_3107 crossref_primary_10_1038_s42003_024_06999_5 crossref_primary_10_1038_srep34529 crossref_primary_10_1146_annurev_biochem_062917_012708 crossref_primary_10_1158_0008_5472_CAN_18_1102 crossref_primary_10_1038_s41467_023_38439_z crossref_primary_10_3390_v17010110 crossref_primary_10_1186_s13046_020_01622_x crossref_primary_10_1016_j_biotechadv_2022_107924 crossref_primary_10_1038_s41467_018_06132_1 crossref_primary_10_1038_s41401_019_0322_9 crossref_primary_10_1016_j_ijbiomac_2024_134580 crossref_primary_10_1161_CIRCGENETICS_117_001556 crossref_primary_10_1038_s41467_021_25552_0 crossref_primary_10_23902_trkjnat_1622077 crossref_primary_10_1111_nph_20141 crossref_primary_10_3389_fgeed_2021_799722 crossref_primary_10_1111_nph_14702 crossref_primary_10_1002_bies_201700023 crossref_primary_10_1038_s43586_021_00093_4 crossref_primary_10_3390_ncrna8050062 crossref_primary_10_1007_s10974_019_09518_w crossref_primary_10_1016_j_lfs_2020_118165 crossref_primary_10_1038_s41598_020_68257_y crossref_primary_10_1080_10717544_2018_1474964 crossref_primary_10_1186_s12885_024_11895_6 crossref_primary_10_3389_fimmu_2021_688132 crossref_primary_10_1016_j_stemcr_2025_102499 crossref_primary_10_1111_febs_14816 crossref_primary_10_1016_j_omtn_2019_04_015 crossref_primary_10_1073_pnas_1707054114 crossref_primary_10_1039_c5ib00263j crossref_primary_10_1016_j_bbrc_2025_152512 crossref_primary_10_1016_j_jgg_2024_05_010 crossref_primary_10_1016_j_molcel_2015_04_028 crossref_primary_10_1242_dev_139683 crossref_primary_10_1017_S0033583519000052 crossref_primary_10_1016_j_tig_2023_10_012 crossref_primary_10_1016_j_ddtec_2018_01_001 crossref_primary_10_1038_s41588_020_0596_3 crossref_primary_10_1038_nrg_2016_118 crossref_primary_10_1093_nar_gkw930 crossref_primary_10_1182_bloodadvances_2023010838 crossref_primary_10_1038_s41467_024_49254_5 crossref_primary_10_3390_biom13071022 crossref_primary_10_1186_s13024_017_0193_9 crossref_primary_10_1038_s41551_022_00865_7 crossref_primary_10_3390_ncrna4030023 crossref_primary_10_1016_j_jgg_2024_05_005 crossref_primary_10_1016_j_ygeno_2020_11_022 crossref_primary_10_1016_j_copbio_2016_03_016 crossref_primary_10_1002_tcr_201800036 crossref_primary_10_1016_j_actbio_2025_03_032 crossref_primary_10_1097_GCO_0000000000001022 crossref_primary_10_1016_j_molmet_2020_101137 crossref_primary_10_3390_ijms242417315 crossref_primary_10_3390_jcdd9040111 crossref_primary_10_1002_sen2_70014 crossref_primary_10_1016_j_tibtech_2023_09_010 crossref_primary_10_1016_j_cell_2017_09_043 crossref_primary_10_1017_S001667231600001X crossref_primary_10_1007_s00122_019_03464_4 crossref_primary_10_1093_bib_bbv068 crossref_primary_10_1371_journal_pone_0319259 crossref_primary_10_1063_1674_0068_cjcp2312129 crossref_primary_10_3389_fgeed_2020_617910 crossref_primary_10_1016_j_copbio_2015_08_006 crossref_primary_10_1007_s00335_015_9565_z crossref_primary_10_3389_fgene_2024_1434002 crossref_primary_10_1007_s00018_022_04324_z crossref_primary_10_1093_nar_gkv546 crossref_primary_10_3390_v13112113 crossref_primary_10_1038_s41588_022_01110_2 crossref_primary_10_1016_j_cels_2024_08_007 crossref_primary_10_1016_j_ymthe_2018_02_031 crossref_primary_10_1093_biomethods_bpy002 crossref_primary_10_1186_s13059_020_02046_8 crossref_primary_10_1016_j_chembiol_2015_12_009 crossref_primary_10_1038_nrm_2016_79 crossref_primary_10_1007_s42994_023_00133_5 crossref_primary_10_1002_med_21439 crossref_primary_10_1038_nrg_2017_97 crossref_primary_10_3390_cancers12092624 crossref_primary_10_1038_s44318_024_00158_6 crossref_primary_10_1007_s11248_019_00181_y crossref_primary_10_1038_s41417_023_00608_z crossref_primary_10_3389_fcell_2021_761709 crossref_primary_10_3389_fimmu_2016_00696 crossref_primary_10_1038_s41596_021_00677_0 crossref_primary_10_1002_bit_25851 crossref_primary_10_1038_s41467_018_05067_x crossref_primary_10_26508_lsa_201800283 crossref_primary_10_7554_eLife_28083 crossref_primary_10_1038_s41421_018_0049_7 crossref_primary_10_1126_scitranslmed_aav8826 crossref_primary_10_1186_s13058_019_1241_x crossref_primary_10_14245_ns_2550462_231 crossref_primary_10_1002_bies_202300210 crossref_primary_10_1007_s00335_021_09928_7 crossref_primary_10_1039_D2BM01466A crossref_primary_10_1038_s41586_023_06564_w crossref_primary_10_1053_j_semperi_2018_09_003 crossref_primary_10_1016_j_cell_2015_06_059 crossref_primary_10_1016_j_neuroscience_2020_06_013 crossref_primary_10_1038_s41596_023_00823_w crossref_primary_10_1631_jzus_B2100009 crossref_primary_10_1111_imr_13241 crossref_primary_10_2337_dbi20_0047 crossref_primary_10_1038_nmeth_3274 crossref_primary_10_1016_j_clon_2019_09_057 crossref_primary_10_1016_j_molcel_2015_02_032 crossref_primary_10_1016_j_jep_2023_116525 crossref_primary_10_1038_nchembio_2253 crossref_primary_10_1016_j_ymthe_2021_08_024 crossref_primary_10_1016_j_brainres_2015_11_009 crossref_primary_10_15252_msb_20199427 crossref_primary_10_1038_s41588_022_01132_w crossref_primary_10_3389_fgeed_2024_1304110 crossref_primary_10_1016_j_csbj_2019_04_012 crossref_primary_10_1186_s12935_019_0773_6 crossref_primary_10_1038_s41419_021_04000_3 crossref_primary_10_1016_j_gene_2022_146518 crossref_primary_10_1161_CIRCRESAHA_122_321692 crossref_primary_10_15252_msb_202110768 crossref_primary_10_3389_fnins_2021_632522 crossref_primary_10_1038_nrg_2017_47 crossref_primary_10_1038_s41467_017_01222_y crossref_primary_10_1128_MCB_00512_15 crossref_primary_10_1007_s40778_018_0140_x crossref_primary_10_1016_j_ymthe_2025_01_031 crossref_primary_10_1186_s43141_021_00225_z crossref_primary_10_3390_ijms24043499 crossref_primary_10_3390_v13112157 crossref_primary_10_1093_jxb_erad175 crossref_primary_10_1016_j_ijcard_2016_11_177 crossref_primary_10_1038_s41419_021_04288_1 crossref_primary_10_1093_nar_gkx1222 crossref_primary_10_1016_j_indcrop_2025_120605 crossref_primary_10_1038_nature22334 crossref_primary_10_3389_fphar_2025_1552741 crossref_primary_10_1016_j_tplants_2025_08_009 crossref_primary_10_1093_gpbjnl_qzaf034 crossref_primary_10_1016_j_jbspin_2016_09_012 crossref_primary_10_1016_j_ymben_2018_04_011 crossref_primary_10_1038_s41380_023_02377_5 crossref_primary_10_1080_24701394_2018_1472773 crossref_primary_10_1002_advs_202402327 crossref_primary_10_1016_j_biotechadv_2016_08_002 crossref_primary_10_1016_j_tibtech_2024_02_007 crossref_primary_10_1007_s11262_022_01960_2 crossref_primary_10_1371_journal_pgen_1011314 crossref_primary_10_1093_nar_gkw883 crossref_primary_10_1016_j_tibtech_2020_11_011 crossref_primary_10_1186_s11658_023_00483_4 crossref_primary_10_1016_j_omtn_2018_11_008 crossref_primary_10_1016_j_omtn_2024_102390 crossref_primary_10_1002_smtd_201600052 crossref_primary_10_1101_gad_311688_118 crossref_primary_10_1016_j_yexcr_2023_113551 crossref_primary_10_1038_s41467_018_07324_5 crossref_primary_10_1186_s13072_015_0050_4 crossref_primary_10_4103_abr_abr_41_19 crossref_primary_10_1016_j_lfs_2019_116636 crossref_primary_10_1038_s41419_019_1983_5 crossref_primary_10_1016_j_tibtech_2020_11_012 crossref_primary_10_1128_spectrum_02627_24 crossref_primary_10_1016_j_molcel_2023_01_010 crossref_primary_10_1016_j_molmed_2019_06_008 crossref_primary_10_1038_s41587_024_02213_3 crossref_primary_10_1038_nchembio_2224 crossref_primary_10_1038_s41467_018_04048_4 crossref_primary_10_1038_s41419_024_06462_7 crossref_primary_10_1146_annurev_genom_083117_021632 crossref_primary_10_1016_j_biotechadv_2017_03_006 crossref_primary_10_1007_s00299_016_1985_z crossref_primary_10_1016_j_copbio_2016_01_005 crossref_primary_10_3390_ijms20184504 crossref_primary_10_1038_s41598_017_18172_6 crossref_primary_10_15252_emmm_202013466 crossref_primary_10_1146_annurev_biochem_013118_111552 crossref_primary_10_7554_eLife_21863 crossref_primary_10_7554_eLife_63254 crossref_primary_10_1038_s41592_024_02537_7 crossref_primary_10_1016_j_cell_2016_10_044 crossref_primary_10_3390_cells12222593 crossref_primary_10_1016_j_csbj_2020_03_020 crossref_primary_10_1126_science_abc6500 crossref_primary_10_1002_adfm_202501532 crossref_primary_10_1016_j_addr_2019_08_011 crossref_primary_10_1016_j_expneurol_2024_114817 crossref_primary_10_1038_s41389_021_00354_7 crossref_primary_10_1038_s41587_024_02240_0 crossref_primary_10_1038_s41467_022_29514_y crossref_primary_10_1002_bab_1913 crossref_primary_10_1038_s41598_023_41367_z crossref_primary_10_1038_s41589_025_01986_1 crossref_primary_10_3390_ijms24043844 crossref_primary_10_1097_COH_0000000000000963 crossref_primary_10_3389_fbioe_2021_758561 crossref_primary_10_1016_j_omtm_2025_101416 crossref_primary_10_1038_s41588_018_0070_7 crossref_primary_10_15252_embr_201846955 crossref_primary_10_1016_j_pnpbp_2017_05_019 crossref_primary_10_1007_s40142_016_0104_3 crossref_primary_10_1038_s41467_024_51694_y crossref_primary_10_1016_j_jbiotec_2020_05_005 crossref_primary_10_1038_s41467_018_05868_0 crossref_primary_10_3390_ijms22073296 crossref_primary_10_1007_s12035_022_03041_9 crossref_primary_10_1038_s41592_019_0508_6 crossref_primary_10_1111_pbi_13296 crossref_primary_10_1002_anie_201504741 crossref_primary_10_1517_14712598_2015_1036736 crossref_primary_10_3389_fonc_2019_01458 crossref_primary_10_1007_s11033_022_07713_6 crossref_primary_10_1016_j_biopha_2020_110572 crossref_primary_10_1111_febs_15652 crossref_primary_10_1007_s10529_020_02860_x crossref_primary_10_1038_nrmicro_2017_29 crossref_primary_10_1038_s41556_020_0563_3 crossref_primary_10_1038_s41467_019_09148_3 crossref_primary_10_1038_s41587_021_01112_1 crossref_primary_10_1002_gcc_23142 crossref_primary_10_1038_mtna_2016_58 crossref_primary_10_1186_s12985_023_02216_7 crossref_primary_10_1016_j_aca_2021_339131 crossref_primary_10_1016_j_molmed_2017_05_004 crossref_primary_10_1146_annurev_bioeng_081723_013033 crossref_primary_10_3233_JCB_15009 crossref_primary_10_1109_RBME_2024_3494715 crossref_primary_10_1002_biot_201700584 crossref_primary_10_1371_journal_pone_0199473 crossref_primary_10_3389_fbioe_2023_1218832 crossref_primary_10_1007_s00401_024_02835_6 crossref_primary_10_1038_517560a crossref_primary_10_1182_blood_2024024599 crossref_primary_10_1016_j_bbamcr_2016_06_009 crossref_primary_10_1016_j_ymthe_2024_06_016 crossref_primary_10_1038_s41587_024_02320_1 crossref_primary_10_1016_j_canlet_2016_02_058 crossref_primary_10_1111_pbi_13232 crossref_primary_10_1016_j_cell_2023_05_003 crossref_primary_10_3389_fpls_2021_773656 crossref_primary_10_1002_1873_3468_14017 crossref_primary_10_1016_j_pmpp_2024_102482 crossref_primary_10_1038_mt_2015_213 crossref_primary_10_3390_ijms17030291 crossref_primary_10_1016_j_tibtech_2024_04_002 crossref_primary_10_3390_cells9122573 crossref_primary_10_1007_s12035_024_04143_2 crossref_primary_10_1016_j_focha_2023_100229 crossref_primary_10_1016_j_molcel_2017_03_007 crossref_primary_10_1002_biot_201700596 crossref_primary_10_1126_science_abg6155 crossref_primary_10_4251_wjgo_v16_i8_3651 crossref_primary_10_1016_j_bbrc_2016_10_130 crossref_primary_10_1124_pharmrev_120_000269 crossref_primary_10_1093_plphys_kiac017 crossref_primary_10_1186_s13059_018_1581_3 crossref_primary_10_2217_epi_2016_0012 crossref_primary_10_1021_jacs_2c02271 crossref_primary_10_1016_j_gene_2019_143968 crossref_primary_10_15252_embj_2022112559 crossref_primary_10_1089_scd_2015_0131 crossref_primary_10_1038_s41467_022_34252_2 crossref_primary_10_1016_j_phrs_2024_107263 crossref_primary_10_1016_j_tig_2021_11_006 crossref_primary_10_3390_ijms23095090 crossref_primary_10_1016_j_cell_2015_02_038 crossref_primary_10_1038_s41583_020_0334_y crossref_primary_10_1038_s41556_019_0454_7 crossref_primary_10_1101_gr_191452_115 crossref_primary_10_1038_nature21076 crossref_primary_10_1016_j_stem_2020_10_014 crossref_primary_10_1016_j_stem_2020_10_015 crossref_primary_10_1002_ana_26656 crossref_primary_10_1016_j_coph_2015_08_008 crossref_primary_10_1016_j_bej_2024_109279 crossref_primary_10_15252_embj_2019101533 crossref_primary_10_1002_adfm_202301256 crossref_primary_10_1038_s41592_024_02502_4 crossref_primary_10_1016_j_bbrc_2016_04_037 crossref_primary_10_1002_biot_201700582 crossref_primary_10_1002_anie_202009240 crossref_primary_10_1038_ncomms14633 crossref_primary_10_1002_ange_201914575 crossref_primary_10_1016_j_lungcan_2019_04_023 crossref_primary_10_7554_eLife_53868
Cites_doi	10.1002/j.1460-2075.1993.tb05691.x 10.1016/j.ccr.2010.11.023 10.1158/1078-0432.CCR-13-3122 10.1038/nature02371 10.1101/gad.831000 10.1016/0092-8674(94)90429-4 10.1093/database/bau093 10.1038/nature11003 10.1158/0008-5472.CAN-11-0140 10.1186/1471-2105-12-323 10.1126/science.1091266 10.1093/bioinformatics/btr260 10.1038/nature12466 10.1038/nature09627 10.1016/j.cell.2013.06.044 10.1073/pnas.95.25.14628 10.1038/nature08460 10.1126/science.1247005 10.1016/j.cell.2014.02.001 10.1038/nature09626 10.1038/nature12688 10.1038/nature10868 10.1038/nrd3320 10.1038/jid.2009.177 10.1038/onc.2008.313 10.1158/2159-8290.CD-11-0341 10.1038/nrc2069 10.1038/nrc2748 10.1126/science.280.5372.2112 10.1038/nmeth.2598 10.1016/j.redox.2014.02.006 10.1073/pnas.0810485105 10.1038/nbt.2675 10.1038/nature13579 10.1016/j.cell.2014.05.010 10.1126/science.1246981 10.1038/nbt.1775 10.1158/2159-8290.CD-13-0424 10.1128/MCB.06373-11 10.1038/nbt.2647 10.1158/0008-5472.CAN-07-2615 10.1371/journal.pbio.1000073 10.1038/nbt.2889 10.1038/nmeth.1923 10.1038/nmeth.2600 10.1073/pnas.1208507109 10.1126/science.1225829 10.1046/j.1356-9597.2001.00492.x 10.1016/j.cell.2014.09.029 10.1016/S1097-2765(00)80216-6 10.1038/nrc2713
ContentType	Journal Article
Copyright	Springer Nature Limited 2014 COPYRIGHT 2015 Nature Publishing Group Copyright Nature Publishing Group Jan 29, 2015
Copyright_xml	– notice: Springer Nature Limited 2014 – notice: COPYRIGHT 2015 Nature Publishing Group – notice: Copyright Nature Publishing Group Jan 29, 2015
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 5PM
DOI	10.1038/nature14136
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials - QC Biological Science Collection eLibrary ProQuest Central ProQuest Technology Collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database ProQuest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database ProQuest Health & Medical Collection Medical Database Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest advanced technologies & aerospace journals ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest One Academic ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology New Engineering collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Agricultural Science Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PATMY name: Environmental Science Database url: http://search.proquest.com/environmentalscience sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Physics
EISSN	1476-4687
EndPage	588
ExternalDocumentID	PMC4420636 3580322101 A660142558 A400038886 25494202 10_1038_nature14136
Genre	Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GeographicLocations	United States
GeographicLocations_xml	– name: United States
GrantInformation_xml	– fundername: NIMH NIH HHS grantid: DP1 MH100706 – fundername: NINDS NIH HHS grantid: R01 NS062849 – fundername: NCCDPHP CDC HHS grantid: DP1-MH100706 – fundername: NINDS NIH HHS grantid: R01-NS07312401
GroupedDBID	--- --Z -DZ -ET -~X .55 .CO .XZ 00M 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3V. 4.4 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAYZH AAZLF ABAWZ ABDBF ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACUHS ACWUS ADBBV ADFRT ADUKH ADYSU ADZCM AENEX AEUYN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B0M BBNVY BCU BDKGC BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HG6 HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PKN PM3 PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YNT YOC YQT YR2 YR5 YXB YZZ Z5M ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~KM AARCD AAYXX ABFSG ABUFD ACSTC ADXHL AETEA AFANA AFFHD ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM ACMFV AEIIB PMFND ESTFP 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK ADGHP C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 5PM
ID	FETCH-LOGICAL-c881t-3cda3e23e3fcf0767b075c3d3dda2b4c003f964cf4057b2e05d75a4c70678a613
IEDL.DBID	P5Z
ISICitedReferencesCount	2108
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000348775000036&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0028-0836 1476-4687
IngestDate	Tue Nov 04 01:49:30 EST 2025 Thu Nov 20 07:39:22 EST 2025 Tue Oct 07 07:02:51 EDT 2025 Sat Nov 29 13:16:53 EST 2025 Sat Nov 29 13:06:22 EST 2025 Sat Nov 29 11:39:13 EST 2025 Sat Nov 29 11:43:08 EST 2025 Tue Jun 10 15:33:48 EDT 2025 Tue Jun 10 15:31:53 EDT 2025 Sat Nov 29 10:01:43 EST 2025 Sun Nov 23 08:44:38 EST 2025 Wed Nov 26 10:15:30 EST 2025 Wed Nov 26 09:32:46 EST 2025 Thu Apr 03 07:09:17 EDT 2025 Sat Nov 29 05:17:39 EST 2025 Tue Nov 18 22:53:25 EST 2025 Fri Feb 21 02:37:57 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	7536
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c881t-3cda3e23e3fcf0767b075c3d3dda2b4c003f964cf4057b2e05d75a4c70678a613
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work.
OpenAccessLink	http://doi.org/10.1038/nature14136
PMID	25494202
PQID	1651539733
PQPubID	40569
PageCount	6
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_4420636 proquest_miscellaneous_1652425801 proquest_journals_1651539733 gale_infotracmisc_A660142558 gale_infotracmisc_A400038886 gale_infotracgeneralonefile_A660142558 gale_infotracgeneralonefile_A400038886 gale_infotraccpiq_660142558 gale_infotraccpiq_400038886 gale_infotracacademiconefile_A660142558 gale_infotracacademiconefile_A400038886 gale_incontextgauss_ISR_A660142558 gale_incontextgauss_ISR_A400038886 pubmed_primary_25494202 crossref_primary_10_1038_nature14136 crossref_citationtrail_10_1038_nature14136 springer_journals_10_1038_nature14136
PublicationCentury	2000
PublicationDate	2015-01-29
PublicationDateYYYYMMDD	2015-01-29
PublicationDate_xml	– month: 01 year: 2015 text: 2015-01-29 day: 29
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationSubtitle	International weekly journal of science
PublicationTitle	Nature (London)
PublicationTitleAbbrev	Nature
PublicationTitleAlternate	Nature
PublicationYear	2015
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Shalem (CR3) 2014; 343 Nishimasu (CR14) 2014; 156 Johannessen (CR23) 2010; 468 Gasiunas, Barrangou, Horvath, Siksnys (CR13) 2012; 109 Shi, Kong, Ribas, Lo (CR29) 2011; 71 Lin (CR36) 2008; 68 Kretzschmar, Kaiser, Lottspeich, Meisterernst (CR18) 1994; 78 Barbie (CR45) 2009; 462 Lemon, Tjian (CR16) 2000; 14 Boutros (CR2) 2004; 303 Lappano, Maggiolini (CR32) 2011; 10 Marinho, Real, Cyrne, Soares, Antunes (CR21) 2014; 2 Smalley (CR49) 2010; 130 Zhang (CR6) 2011; 29 Corcoran (CR27) 2012; 2 Langmead, Salzberg (CR47) 2012; 9 Hart (CR51) 1998; 280 Hsu, Lander, Zhang (CR41) 2014; 157 Villanueva (CR28) 2010; 18 Gilbert (CR42) 2014; 159 Neely (CR20) 1999; 4 Peabody (CR15) 1993; 12 Wu (CR22) 2014; 32 Musgrove, Sutherland (CR25) 2009; 9 Berns (CR1) 2004; 428 Desgrosellier, Cheresh (CR34) 2010; 10 Wilks (CR37) 2014; 2014 CR19 Dorsam, Gutkind (CR31) 2007; 7 Li, Dewey (CR48) 2011; 12 Maeder (CR9) 2013; 10 Barretina (CR35) 2012; 483 Jinek (CR12) 2012; 337 Nazarian (CR24) 2010; 468 Wong (CR50) 2012; 32 Anders, Niewoehner, Duerst, Jinek (CR40) 2014; 513 Luo (CR44) 2008; 105 Gilbert (CR7) 2013; 154 Rizos (CR38) 2014; 20 Mali (CR11) 2013; 31 Konieczkowski (CR39) 2014; 4 Liberzon (CR46) 2011; 27 Beerli, Segal, Dreier, Barbas (CR5) 1998; 95 Prahallad (CR26) 2012; 483 van Essen, Engist, Natoli, Saccani (CR17) 2009; 7 Franke (CR33) 2008; 27 Johannessen (CR30) 2013; 504 Wang, Wei, Sabatini, Lander (CR4) 2014; 343 Konermann (CR8) 2013; 500 Perez-Pinera (CR10) 2013; 10 Hsu (CR43) 2013; 31 LA Gilbert (BFnature14136_CR42) 2014; 159 C Wilks (BFnature14136_CR37) 2014; 2014 S Konermann (BFnature14136_CR8) 2013; 500 H Rizos (BFnature14136_CR38) 2014; 20 O Shalem (BFnature14136_CR3) 2014; 343 C Anders (BFnature14136_CR40) 2014; 513 DJ Konieczkowski (BFnature14136_CR39) 2014; 4 EA Musgrove (BFnature14136_CR25) 2009; 9 B Luo (BFnature14136_CR44) 2008; 105 PP Wong (BFnature14136_CR50) 2012; 32 D van Essen (BFnature14136_CR17) 2009; 7 CM Johannessen (BFnature14136_CR30) 2013; 504 A Liberzon (BFnature14136_CR46) 2011; 27 ML Maeder (BFnature14136_CR9) 2013; 10 K Berns (BFnature14136_CR1) 2004; 428 F Zhang (BFnature14136_CR6) 2011; 29 KE Neely (BFnature14136_CR20) 1999; 4 P Mali (BFnature14136_CR11) 2013; 31 G Gasiunas (BFnature14136_CR13) 2012; 109 CM Johannessen (BFnature14136_CR23) 2010; 468 RB Corcoran (BFnature14136_CR27) 2012; 2 H Shi (BFnature14136_CR29) 2011; 71 JS Desgrosellier (BFnature14136_CR34) 2010; 10 BFnature14136_CR19 R Nazarian (BFnature14136_CR24) 2010; 468 A Prahallad (BFnature14136_CR26) 2012; 483 R Lappano (BFnature14136_CR32) 2011; 10 J Villanueva (BFnature14136_CR28) 2010; 18 B Li (BFnature14136_CR48) 2011; 12 P Perez-Pinera (BFnature14136_CR10) 2013; 10 HS Marinho (BFnature14136_CR21) 2014; 2 PD Hsu (BFnature14136_CR41) 2014; 157 H Nishimasu (BFnature14136_CR14) 2014; 156 RR Beerli (BFnature14136_CR5) 1998; 95 X Wu (BFnature14136_CR22) 2014; 32 M Kretzschmar (BFnature14136_CR18) 1994; 78 MJ Hart (BFnature14136_CR51) 1998; 280 J Barretina (BFnature14136_CR35) 2012; 483 M Boutros (BFnature14136_CR2) 2004; 303 T Wang (BFnature14136_CR4) 2014; 343 RT Dorsam (BFnature14136_CR31) 2007; 7 DA Barbie (BFnature14136_CR45) 2009; 462 LA Gilbert (BFnature14136_CR7) 2013; 154 M Jinek (BFnature14136_CR12) 2012; 337 WM Lin (BFnature14136_CR36) 2008; 68 TF Franke (BFnature14136_CR33) 2008; 27 B Langmead (BFnature14136_CR47) 2012; 9 DS Peabody (BFnature14136_CR15) 1993; 12 PD Hsu (BFnature14136_CR43) 2013; 31 B Lemon (BFnature14136_CR16) 2000; 14 KS Smalley (BFnature14136_CR49) 2010; 130 26000839 - Mol Cell. 2015 May 21;58(4):560-2 25798470 - Nat Methods. 2015 Feb;12(2):102-3 25631441 - Nature. 2015 Jan 29;517(7536):560-2 27863416 - Oncotarget. 2016 Dec 6;7(49):80103-80104 29729207 - Acta Physiol (Oxf). 2018 Sep;224(1):e13087
References_xml	– volume: 14 start-page: 2551 year: 2000 end-page: 2569 ident: CR16 article-title: Orchestrated response: a symphony of transcription factors for gene control publication-title: Genes Dev. – volume: 95 start-page: 14628 year: 1998 end-page: 14633 ident: CR5 article-title: Toward controlling gene expression at will: specific regulation of the promoter by using polydactyl zinc finger proteins constructed from modular building blocks publication-title: Proc. Natl Acad. Sci. USA – volume: 2 start-page: 535 year: 2014 end-page: 562 ident: CR21 article-title: Hydrogen peroxide sensing, signaling and regulation of transcription factors publication-title: Redox Biol. – volume: 500 start-page: 472 year: 2013 end-page: 476 ident: CR8 article-title: Optical control of mammalian endogenous transcription and epigenetic states publication-title: Nature – volume: 12 start-page: 323 year: 2011 ident: CR48 article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome publication-title: BMC Bioinformatics – volume: 483 start-page: 100 year: 2012 end-page: 103 ident: CR26 article-title: Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR publication-title: Nature – volume: 4 start-page: 649 year: 1999 end-page: 655 ident: CR20 article-title: Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays publication-title: Mol. Cell – volume: 31 start-page: 827 year: 2013 end-page: 832 ident: CR43 article-title: DNA targeting specificity of RNA-guided Cas9 nucleases publication-title: Nature Biotechnol. – volume: 9 start-page: 631 year: 2009 end-page: 643 ident: CR25 article-title: Biological determinants of endocrine resistance in breast cancer publication-title: Nature Rev. Cancer – volume: 337 start-page: 816 year: 2012 end-page: 821 ident: CR12 article-title: A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity publication-title: Science – volume: 130 start-page: 28 year: 2010 end-page: 37 ident: CR49 article-title: Understanding melanoma signaling networks as the basis for molecular targeted therapy publication-title: J. Invest. Dermatol. – volume: 10 start-page: 973 year: 2013 end-page: 976 ident: CR10 article-title: RNA-guided gene activation by CRISPR-Cas9-based transcription factors publication-title: Nature Methods – volume: 109 start-page: E2579 year: 2012 end-page: E2586 ident: CR13 article-title: Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria publication-title: Proc. Natl Acad. Sci. USA – ident: CR19 – volume: 4 start-page: 816 year: 2014 end-page: 827 ident: CR39 article-title: A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors publication-title: Cancer Discov. – volume: 2014 start-page: bau093 year: 2014 ident: CR37 article-title: The Cancer Genomics Hub (CGHub): overcoming cancer through the power of torrential data publication-title: Database – volume: 157 start-page: 1262 year: 2014 end-page: 1278 ident: CR41 article-title: Development and applications of CRISPR-Cas9 for genome engineering publication-title: Cell – volume: 68 start-page: 664 year: 2008 end-page: 673 ident: CR36 article-title: Modeling genomic diversity and tumor dependency in malignant melanoma publication-title: Cancer Res. – volume: 428 start-page: 431 year: 2004 end-page: 437 ident: CR1 article-title: A large-scale RNAi screen in human cells identifies new components of the p53 pathway publication-title: Nature – volume: 468 start-page: 968 year: 2010 end-page: 972 ident: CR23 article-title: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation publication-title: Nature – volume: 12 start-page: 595 year: 1993 end-page: 600 ident: CR15 article-title: The RNA binding site of bacteriophage MS2 coat protein publication-title: EMBO J. – volume: 7 start-page: e73 year: 2009 ident: CR17 article-title: Two modes of transcriptional activation at native promoters by NF-κB p65 publication-title: PLoS Biol. – volume: 32 start-page: 670 year: 2014 end-page: 676 ident: CR22 article-title: Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells publication-title: Nature Biotechnol. – volume: 156 start-page: 935 year: 2014 end-page: 949 ident: CR14 article-title: Crystal structure of Cas9 in complex with guide RNA and target DNA publication-title: Cell – volume: 504 start-page: 138 year: 2013 end-page: 142 ident: CR30 article-title: A melanocyte lineage program confers resistance to MAP kinase pathway inhibition publication-title: Nature – volume: 513 start-page: 569 year: 2014 end-page: 573 ident: CR40 article-title: Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease publication-title: Nature – volume: 462 start-page: 108 year: 2009 end-page: 112 ident: CR45 article-title: Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 publication-title: Nature – volume: 27 start-page: 6473 year: 2008 end-page: 6488 ident: CR33 article-title: PI3K/Akt: getting it right matters publication-title: Oncogene – volume: 10 start-page: 977 year: 2013 end-page: 979 ident: CR9 article-title: CRISPR RNA-guided activation of endogenous human genes publication-title: Nature Methods – volume: 343 start-page: 80 year: 2014 end-page: 84 ident: CR4 article-title: Genetic screens in human cells using the CRISPR-Cas9 system publication-title: Science – volume: 105 start-page: 20380 year: 2008 end-page: 20385 ident: CR44 article-title: Highly parallel identification of essential genes in cancer cells publication-title: Proc. Natl Acad. Sci. USA – volume: 10 start-page: 9 year: 2010 end-page: 22 ident: CR34 article-title: Integrins in cancer: biological implications and therapeutic opportunities publication-title: Nature Rev. Cancer – volume: 483 start-page: 603 year: 2012 end-page: 607 ident: CR35 article-title: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity publication-title: Nature – volume: 343 start-page: 84 year: 2014 end-page: 87 ident: CR3 article-title: Genome-scale CRISPR-Cas9 knockout screening in human cells publication-title: Science – volume: 303 start-page: 832 year: 2004 end-page: 835 ident: CR2 article-title: Genome-wide RNAi analysis of growth and viability in cells publication-title: Science – volume: 71 start-page: 5067 year: 2011 end-page: 5074 ident: CR29 article-title: Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to B-RAF inhibition publication-title: Cancer Res. – volume: 10 start-page: 47 year: 2011 end-page: 60 ident: CR32 article-title: G protein-coupled receptors: novel targets for drug discovery in cancer publication-title: Nature Rev. Drug Discov. – volume: 20 start-page: 1965 year: 2014 end-page: 1977 ident: CR38 article-title: BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact publication-title: Clin. Cancer Res. – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: CR47 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nature Methods – volume: 29 start-page: 149 year: 2011 end-page: 153 ident: CR6 article-title: Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription publication-title: Nature Biotechnol. – volume: 78 start-page: 525 year: 1994 end-page: 534 ident: CR18 article-title: A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators publication-title: Cell – volume: 31 start-page: 833 year: 2013 end-page: 838 ident: CR11 article-title: CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering publication-title: Nature Biotechnol. – volume: 32 start-page: 1633 year: 2012 end-page: 1644 ident: CR50 article-title: Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor ( ) publication-title: Mol. Cell. Biol. – volume: 154 start-page: 442 year: 2013 end-page: 451 ident: CR7 article-title: CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes publication-title: Cell – volume: 159 start-page: 647 year: 2014 end-page: 661 ident: CR42 article-title: Genome-scale CRISPR-mediated control of gene repression and activation publication-title: Cell – volume: 27 start-page: 1739 year: 2011 end-page: 1740 ident: CR46 article-title: Molecular signatures database (MSigDB) 3.0 publication-title: Bioinformatics – volume: 468 start-page: 973 year: 2010 end-page: 977 ident: CR24 article-title: Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation publication-title: Nature – volume: 280 start-page: 2112 year: 1998 end-page: 2114 ident: CR51 article-title: Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13 publication-title: Science – volume: 7 start-page: 79 year: 2007 end-page: 94 ident: CR31 article-title: G-protein-coupled receptors and cancer publication-title: Nature Rev. Cancer – volume: 2 start-page: 227 year: 2012 end-page: 235 ident: CR27 article-title: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib publication-title: Cancer Discov. – volume: 18 start-page: 683 year: 2010 end-page: 695 ident: CR28 article-title: Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K publication-title: Cancer Cell – volume: 12 start-page: 595 year: 1993 ident: BFnature14136_CR15 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1993.tb05691.x – volume: 18 start-page: 683 year: 2010 ident: BFnature14136_CR28 publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.11.023 – volume: 20 start-page: 1965 year: 2014 ident: BFnature14136_CR38 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-13-3122 – volume: 428 start-page: 431 year: 2004 ident: BFnature14136_CR1 publication-title: Nature doi: 10.1038/nature02371 – volume: 14 start-page: 2551 year: 2000 ident: BFnature14136_CR16 publication-title: Genes Dev. doi: 10.1101/gad.831000 – volume: 78 start-page: 525 year: 1994 ident: BFnature14136_CR18 publication-title: Cell doi: 10.1016/0092-8674(94)90429-4 – volume: 2014 start-page: bau093 year: 2014 ident: BFnature14136_CR37 publication-title: Database doi: 10.1093/database/bau093 – volume: 483 start-page: 603 year: 2012 ident: BFnature14136_CR35 publication-title: Nature doi: 10.1038/nature11003 – volume: 71 start-page: 5067 year: 2011 ident: BFnature14136_CR29 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-11-0140 – volume: 12 start-page: 323 year: 2011 ident: BFnature14136_CR48 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-12-323 – volume: 303 start-page: 832 year: 2004 ident: BFnature14136_CR2 publication-title: Science doi: 10.1126/science.1091266 – volume: 27 start-page: 1739 year: 2011 ident: BFnature14136_CR46 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr260 – volume: 500 start-page: 472 year: 2013 ident: BFnature14136_CR8 publication-title: Nature doi: 10.1038/nature12466 – volume: 468 start-page: 968 year: 2010 ident: BFnature14136_CR23 publication-title: Nature doi: 10.1038/nature09627 – volume: 154 start-page: 442 year: 2013 ident: BFnature14136_CR7 publication-title: Cell doi: 10.1016/j.cell.2013.06.044 – volume: 95 start-page: 14628 year: 1998 ident: BFnature14136_CR5 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.95.25.14628 – volume: 462 start-page: 108 year: 2009 ident: BFnature14136_CR45 publication-title: Nature doi: 10.1038/nature08460 – volume: 343 start-page: 84 year: 2014 ident: BFnature14136_CR3 publication-title: Science doi: 10.1126/science.1247005 – volume: 156 start-page: 935 year: 2014 ident: BFnature14136_CR14 publication-title: Cell doi: 10.1016/j.cell.2014.02.001 – volume: 468 start-page: 973 year: 2010 ident: BFnature14136_CR24 publication-title: Nature doi: 10.1038/nature09626 – volume: 504 start-page: 138 year: 2013 ident: BFnature14136_CR30 publication-title: Nature doi: 10.1038/nature12688 – volume: 483 start-page: 100 year: 2012 ident: BFnature14136_CR26 publication-title: Nature doi: 10.1038/nature10868 – volume: 10 start-page: 47 year: 2011 ident: BFnature14136_CR32 publication-title: Nature Rev. Drug Discov. doi: 10.1038/nrd3320 – volume: 130 start-page: 28 year: 2010 ident: BFnature14136_CR49 publication-title: J. Invest. Dermatol. doi: 10.1038/jid.2009.177 – volume: 27 start-page: 6473 year: 2008 ident: BFnature14136_CR33 publication-title: Oncogene doi: 10.1038/onc.2008.313 – volume: 2 start-page: 227 year: 2012 ident: BFnature14136_CR27 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-11-0341 – volume: 7 start-page: 79 year: 2007 ident: BFnature14136_CR31 publication-title: Nature Rev. Cancer doi: 10.1038/nrc2069 – volume: 10 start-page: 9 year: 2010 ident: BFnature14136_CR34 publication-title: Nature Rev. Cancer doi: 10.1038/nrc2748 – volume: 280 start-page: 2112 year: 1998 ident: BFnature14136_CR51 publication-title: Science doi: 10.1126/science.280.5372.2112 – volume: 10 start-page: 977 year: 2013 ident: BFnature14136_CR9 publication-title: Nature Methods doi: 10.1038/nmeth.2598 – volume: 2 start-page: 535 year: 2014 ident: BFnature14136_CR21 publication-title: Redox Biol. doi: 10.1016/j.redox.2014.02.006 – volume: 105 start-page: 20380 year: 2008 ident: BFnature14136_CR44 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0810485105 – volume: 31 start-page: 833 year: 2013 ident: BFnature14136_CR11 publication-title: Nature Biotechnol. doi: 10.1038/nbt.2675 – volume: 513 start-page: 569 year: 2014 ident: BFnature14136_CR40 publication-title: Nature doi: 10.1038/nature13579 – volume: 157 start-page: 1262 year: 2014 ident: BFnature14136_CR41 publication-title: Cell doi: 10.1016/j.cell.2014.05.010 – volume: 343 start-page: 80 year: 2014 ident: BFnature14136_CR4 publication-title: Science doi: 10.1126/science.1246981 – volume: 29 start-page: 149 year: 2011 ident: BFnature14136_CR6 publication-title: Nature Biotechnol. doi: 10.1038/nbt.1775 – volume: 4 start-page: 816 year: 2014 ident: BFnature14136_CR39 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-13-0424 – volume: 32 start-page: 1633 year: 2012 ident: BFnature14136_CR50 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.06373-11 – volume: 31 start-page: 827 year: 2013 ident: BFnature14136_CR43 publication-title: Nature Biotechnol. doi: 10.1038/nbt.2647 – volume: 68 start-page: 664 year: 2008 ident: BFnature14136_CR36 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-2615 – volume: 7 start-page: e73 year: 2009 ident: BFnature14136_CR17 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000073 – volume: 32 start-page: 670 year: 2014 ident: BFnature14136_CR22 publication-title: Nature Biotechnol. doi: 10.1038/nbt.2889 – volume: 9 start-page: 357 year: 2012 ident: BFnature14136_CR47 publication-title: Nature Methods doi: 10.1038/nmeth.1923 – volume: 10 start-page: 973 year: 2013 ident: BFnature14136_CR10 publication-title: Nature Methods doi: 10.1038/nmeth.2600 – volume: 109 start-page: E2579 year: 2012 ident: BFnature14136_CR13 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1208507109 – volume: 337 start-page: 816 year: 2012 ident: BFnature14136_CR12 publication-title: Science doi: 10.1126/science.1225829 – ident: BFnature14136_CR19 doi: 10.1046/j.1356-9597.2001.00492.x – volume: 159 start-page: 647 year: 2014 ident: BFnature14136_CR42 publication-title: Cell doi: 10.1016/j.cell.2014.09.029 – volume: 4 start-page: 649 year: 1999 ident: BFnature14136_CR20 publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80216-6 – volume: 9 start-page: 631 year: 2009 ident: BFnature14136_CR25 publication-title: Nature Rev. Cancer doi: 10.1038/nrc2713 – reference: 25631441 - Nature. 2015 Jan 29;517(7536):560-2 – reference: 27863416 - Oncotarget. 2016 Dec 6;7(49):80103-80104 – reference: 29729207 - Acta Physiol (Oxf). 2018 Sep;224(1):e13087 – reference: 26000839 - Mol Cell. 2015 May 21;58(4):560-2 – reference: 25798470 - Nat Methods. 2015 Feb;12(2):102-3
SSID	ssj0005174
Score	2.6732583
Snippet	Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe... Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. We describe structure-guided...
SourceID	pubmedcentral proquest gale pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	583
SubjectTerms	45/23 631/337/572/2102 Cell Line, Tumor Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR-Associated Proteins - genetics CRISPR-Associated Proteins - metabolism CRISPR-Cas Systems - genetics Crystal structure DNA, Complementary - biosynthesis DNA, Complementary - genetics Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzymes Epigenetics Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Library Genetic aspects Genetic engineering Genetic Engineering - methods Genetic Loci - genetics Genetic regulation Genetic research Genetic Testing Genetic transcription Genome, Human - genetics Genomes Genomics Health aspects Humanities and Social Sciences Humans Indoles - pharmacology Melanoma Melanoma - drug therapy Melanoma - genetics multidisciplinary Nucleotide sequence Proteins Proto-Oncogene Proteins B-raf - antagonists & inhibitors Reproducibility of Results RNA, Untranslated - biosynthesis RNA, Untranslated - genetics RNA, Untranslated - metabolism Science Sulfonamides - pharmacology Transcription factors Transcriptional Activation - genetics Up-Regulation - genetics
Title	Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
URI	https://link.springer.com/article/10.1038/nature14136 https://www.ncbi.nlm.nih.gov/pubmed/25494202 https://www.proquest.com/docview/1651539733 https://www.proquest.com/docview/1652425801 https://pubmed.ncbi.nlm.nih.gov/PMC4420636
Volume	517
WOSCitedRecordID	wos000348775000036&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAQT databaseName: Nature customDbUrl: eissn: 1476-4687 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: RNT dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.nature.com providerName: Nature Publishing – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M0K dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7P dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PCBAR dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7S dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PATMY dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7X7 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: KB. dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7RV dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest advanced technologies & aerospace journals customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: P5Z dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: BENPR dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2M dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 8C1 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2O dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2P dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYBhIvwMZX2KgC4lsKS5wPO0-oqzYxjZaoG6jwEiWOMypB2i0tgv-eO8fpklKVB15OrXw-OfL57myff0fIMyFgl5zliLGfM8tjNLEScEQW5-CsmGQptatiE2ww4KNRGOkDt1KnVdY2URnqbCLwjHzfwZrd4Dxd9930wsKqUXi7qktobJAtREnAhRn5X69SPJZQmPX7PNvl-xVspgMmPGh5pGW73HBMy0mTSzenyiEd3f7fT7lDbulQ1OxWurNNrslih9xQKaGi3CHbetmX5iuNTf36LvkAPyc_pFXC1Epzho6uNjsgCh9JVEe8ZvrbTApTarRDmZm94fFpNLR6SRmaKo9d_rpHPh0dnvXeW7oggyU4d2aWK7LEldSVbi5ymwUshYBDuJmbZQlNPQEWIg8DT-QYBaZU2n7G_MQTDF1iAoHDfbJZTAr5kJihD2G9cJ0gpI6XiSCVvqAhSBUSQrgsNMibelJiodHKsWjG91jdmrs8bsygATpXM08rkI7VbE9xdmOEvSgwr-Y8mZdlfHw6jLueuiPlfC1TALtXsHE-N8hLzZRPYFQi0W8Z4NsQTqsl7h-cDZm7LU4xHV_EDTkrWht9X7Razyu1WDWc9YwNiXstRjA6oiVnVXOzd635sbaJZXyl9gZ5smjGnpjnV8jJXPHgHhjCJoM8qNbbYkbxKMOjNjUIa63EBQMipbdbivE3hZjuQb8AFeB5vWYbw_pbUR6tH_4uuQkWDHNeLRrukc3Z5Vw-JtfFz9m4vOyQDTb8jHTEFOVAec_pkK2Dw0E0hH8nB2-B9u0TpLSv6EdFI6SsoqcdZcygX9Q963_5A5wmmkk
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VAoIL0PIyLWAQhYJkNd51vPYBoSpQNWqIqrRIuW3t9bpEAjutE6B_it_IjB-pHaJw6oFbpJ0dreOZb3bWs98AvFIKs-QoJo79WFiOYIEVYCCyPA-DldAiZK2i2YTo973h0D9cgd_VXRgqq6wwMQfqKFV0Rr5jU89uDJ6cfxifWdQ1ir6uVi00CrM40Bc_MWXL3nc_4vvdYmzv03Fn3yq7CljK8-yJxVUUcM245rGKMYsXIUZNxSMeRQELHYVmHvuuo2LayoRMt9qRaAeOEoTrAUY_1HsNriOOCyohE0NxWVIyx_pc3gdscW-noOm0MWS4jQg4HwdqgXC-SHPuS20eAPfu_m9_3T24U261zd3CN9ZgRSfrcDMveVXZOqyVsJaZ2yX39tv70MOf6XdtZWi62pxQIK9gFVXRJZDiCNsML8wgMXXJ5qgjszPoHh0OrE6Q-WZep69_PYAvV_J8D2E1SRP9GEy_jWmL4rbrM9uJlBvqtmI-alUat6iRb8C7ygikKtnYqSnIN5lXBXBP1izGQJ-qhMcFCclisZdkTZJoPRKqGzoNplkmu0cDuevk34A9b6mQi9k5YnjbM-BNKRSnuCoVlHc18NmILqyh7h-SNZ0bDUk1Hp3Jmp4Fo7W5rxujp4VZLFrOcsGaxs2GIIKqauhZNFyfXXmaLDE_k5duZsCL2TDNpDrGRKfTXIZyfNwWGvCo8O_ZG6WjGoe1mAGi4fkzAWKCb44ko685I7yD81wygK0KI2rL-ttQnixf_nO4tX_8uSd73f7BBtxGtKb6Xov5m7A6OZ_qp3BD_ZiMsvNnOfyZcHLVoPEHwgvpxQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwED-N8SFegI2vsAEBMb6kqI2dzweEpo6KalNVdUOaeDGJ44xKkHZLC-xf46_jLnG6pFTlaQ-8VfL55NTn389nn-8AXkiJXnKSUo791Lccn0VWhERkBQGSla_8mLXLYhN-vx8cH4eDNfhdvYWhsMoKEwugTsaSzshbNtXsRvLkvJXqsIjBXvf95NSiClJ001qV0yhNZF-d_0T3LX_X28O53mGs--Go89HSFQYsGQT21OIyibhiXPFUpujR-zEyqOQJT5KIxY5Ek09Dz5EpbWtiptpu4ruRI33C-AiZEPVegas--pjk-A3czxfhJQsZoPXbwDYPWmXKThvpw2uw4SIn1EhxMWBz4da2IMPu7f_5b7wDt_QW3Nwt18wGrKlsE64XobAy34QNDXe5-Vrn5H5zFw7w5_i7snI0aWVOieAruEVV9DikPNo243MzykylszyqxOwMe4eDodWJ8tAs4vfVr3vw6VK-7z6sZ-NMPQQzdNGdkdz2QmY7ifRi5UoWolapcOuahAa8rQxCSJ2lnYqFfBNFtAAPRM16DFxrlfCkTE6yXOw5WZagdB8ZzfhJNMtz0Tscil2nuBsOgpVCHnrtiO1uYMArLZSOcVQy0m848NsojVhD3T8kazq3GpJyMjoVNT1LWmt9XzZaT0qzWDac1YI1jdsNQQRb2dCzrLneu1p1QnNBLi6WnAHP5s3Uk-IbMzWeFTLk--N20YAH5Vqfzygd4TiszQzwGygwF6AM8c2WbPS1yBTvYD-PDGCnwovasP42lEerh_8UbiBWiINef38LbiKIU9ivxcJtWJ-ezdRjuCZ_TEf52ZMCCU34ctmY8QcR0_K4
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome-scale+transcriptional+activation+by+an+engineered+CRISPR-Cas9+complex&rft.jtitle=Nature+%28London%29&rft.au=Konermann%2C+Silvana&rft.au=Brigham%2C+Mark+D&rft.au=Trevino%2C+Alexandro+E&rft.au=Joung%2C+Julia&rft.date=2015-01-29&rft.pub=Nature+Publishing+Group&rft.issn=0028-0836&rft.spage=583&rft_id=info:doi/10.1038%2Fnature14136&rft.externalDocID=A400038886
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon