Chronic inflammation in the etiology of disease across the life span

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that colle...

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Vydané v:	Nature medicine Ročník 25; číslo 12; s. 1822 - 1832
Hlavní autori:	Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W, Fasano, Alessio, Miller, Gary W, Miller, Andrew H, Mantovani, Alberto, Weyand, Cornelia M, Barzilai, Nir, Goronzy, Jorg J, Rando, Thomas A, Effros, Rita B, Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Nature Publishing Group 01.12.2019
Predmet:	Aging Autoimmune Diseases - etiology Autoimmune Diseases - physiopathology Behavior Biology Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Chronic Disease - epidemiology Chronic infection Cytokines Diabetes Diabetes mellitus Diabetes Mellitus - etiology Diabetes Mellitus - physiopathology Environmental health Etiology Fatty liver Health risk assessment Health sciences Hospitals Humans Infections Inflammation Inflammation - complications Inflammation - epidemiology Inflammation - physiopathology Insulin resistance Ischemia Kidney diseases Life span Life Style Liver diseases Longevity - genetics Longevity - physiology Medicine Metabolic syndrome Mortality Neoplasms - etiology Neoplasms - physiopathology Neurodegenerative diseases Neurodegenerative Diseases - etiology Neurodegenerative Diseases - physiopathology Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - physiopathology Pathogens Phenotypes Psychological stress Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - physiopathology Risk analysis Risk Factors Toxicants
ISSN:	1078-8956, 1546-170X, 1546-170X
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Popis
Shrnutí:	Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23
ISSN:	1078-8956 1546-170X 1546-170X
DOI:	10.1038/s41591-019-0675-0