Chronic inflammation in the etiology of disease across the life span

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that colle...

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Bibliographic Details
Published in:Nature medicine Vol. 25; no. 12; pp. 1822 - 1832
Main Authors: Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W, Fasano, Alessio, Miller, Gary W, Miller, Andrew H, Mantovani, Alberto, Weyand, Cornelia M, Barzilai, Nir, Goronzy, Jorg J, Rando, Thomas A, Effros, Rita B, Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M
Format: Journal Article
Language:English
Published: United States Nature Publishing Group 01.12.2019
Subjects:
Aging
Autoimmune Diseases - etiology
Autoimmune Diseases - physiopathology
Behavior
Biology
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Cardiovascular Diseases - physiopathology
Chronic Disease - epidemiology
Chronic infection
Cytokines
Diabetes
Diabetes mellitus
Diabetes Mellitus - etiology
Diabetes Mellitus - physiopathology
Environmental health
Etiology
Fatty liver
Health risk assessment
Health sciences
Hospitals
Humans
Infections
Inflammation
Inflammation - complications
Inflammation - epidemiology
Inflammation - physiopathology
Insulin resistance
Ischemia
Kidney diseases
Life span
Life Style
Liver diseases
Longevity - genetics
Longevity - physiology
Medicine
Metabolic syndrome
Mortality
Neoplasms - etiology
Neoplasms - physiopathology
Neurodegenerative diseases
Neurodegenerative Diseases - etiology
Neurodegenerative Diseases - physiopathology
Non-alcoholic Fatty Liver Disease - etiology
Non-alcoholic Fatty Liver Disease - physiopathology
Pathogens
Phenotypes
Psychological stress
Renal Insufficiency, Chronic - etiology
Renal Insufficiency, Chronic - physiopathology
Risk analysis
Risk Factors
Toxicants
ISSN:1078-8956, 1546-170X, 1546-170X
Online Access:Get full text
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Summary:Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
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ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/s41591-019-0675-0