Structures of transcription pre-initiation complex with TFIIH and Mediator

For the initiation of transcription, RNA polymerase II (Pol II) assembles with general transcription factors on promoter DNA to form the pre-initiation complex (PIC). Here we report cryo-electron microscopy structures of the Saccharomyces cerevisiae PIC and PIC–core Mediator complex at nominal resol...

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Bibliographic Details
Published in:	Nature (London) Vol. 551; no. 7679; pp. 204 - 209
Main Authors:	Schilbach, S., Hantsche, M., Tegunov, D., Dienemann, C., Wigge, C., Urlaub, H., Cramer, P.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.11.2017 Nature Publishing Group
Subjects:	13/109 14/28 631/1647/296 631/337/572 631/45/147 631/535/1258/1259 631/92/607/1167 82/58 82/80 82/83 Analysis Brewer's yeast Coordination compounds Cryoelectron Microscopy Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism DNA binding proteins DNA repair DNA-directed RNA polymerase Electron microscopy Genetic aspects Genetic transcription Homology Humanities and Social Sciences Identification and classification Initiation complex Kinases Mediator Complex - chemistry Mediator Complex - metabolism Mediator Complex - ultrastructure Microscopy Models, Molecular multidisciplinary Observations Open spaces Phosphorylation Promoter Regions, Genetic Protein Binding Protein Subunits - chemistry Protein Subunits - metabolism Proteins Ribonucleic acid RNA RNA polymerase II RNA Polymerase II - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - ultrastructure Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - ultrastructure Science Structure Transcription (Genetics) Transcription factors Transcription Factors, TFII - chemistry Transcription Factors, TFII - metabolism Transcription Factors, TFII - ultrastructure Transcription Initiation, Genetic Yeast Germany
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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