The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine

Osteopontin (Opn), a multifunctional extracellular matrix protein, is implicated in the pathogenesis of various inflammatory disorders. Under physiologic conditions, its expression is restricted to certain tissues including bone and kidney tubule. However, cellular activation during disease developm...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 3; p. e0173629
Main Authors:	Ito, Koyu, Nakajima, Akira, Fukushima, Yuji, Suzuki, Keiichiro, Sakamoto, Keiko, Hamazaki, Yoko, Ogasawara, Kouetsu, Minato, Nagahiro, Hattori, Masakazu
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15.03.2017 Public Library of Science (PLoS)
Subjects:	Animal tissues Animals Antigens Bacteria Bacterial Physiological Phenomena Biocompatibility Biology Biology and Life Sciences Blocking antibodies Disease Epithelium Extracellular matrix Fecal microflora Gene Expression Profiling Homeostasis Homeostasis - physiology Immune system Immunoglobulins Immunology Inflammatory bowel disease Inflammatory diseases Intestinal microflora Intestine Intestines Intestines - microbiology Laboratory animals Lamina propria Lymphocytes Lymphocytes T Matrix protein Medicine Medicine and Health Sciences Mice Mice, Transgenic Microbiota Microbiota (Symbiotic organisms) Osteopontin Osteopontin - physiology Pathogenesis Peptides Physiological aspects Rodents Stem cells Survival Survival factor
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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