Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic, including Indonesia. However, there are only limited data regarding the precise prevalence of the COVID-19 pandemic in Indonesia. Here, to estimate the magnitude o...

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Veröffentlicht in:PLOS ONE Jg. 16; H. 5; S. e0251234
Hauptverfasser: Megasari, Ni Luh Ayu, Utsumi, Takako, Yamani, Laura Navika, Juniastuti, Gunawan, Emily, Furukawa, Koichi, Nishimura, Mitsuhiro, Lusida, Maria Inge, Mori, Yasuko
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science (PLoS) 06.05.2021
Public Library of Science
Schlagworte:
Adolescent
Adult
Analysis
Antibodies
Antibodies, Viral
Asymptomatic
Biology and life sciences
Blood & organ donations
Collaboration
Coronaviruses
COVID-19
Criteria
Data analysis
Disease susceptibility
Disease transmission
Editing
Epidemiology
Fatalities
Female
Graduate schools
Graduate studies
Health facilities
Health risks
Humans
Immunoglobulin G
Indonesia
Infections
Infectious diseases
Laboratories
Male
Medical personnel
Medical research
Medicine
Medicine and Health Sciences
Methodology
Middle Aged
Patients
People and Places
Polymerase chain reaction
Population
Public health
Q
R
Research facilities
Respiratory diseases
Rural areas
SARS-CoV-2
Science
Seroepidemiologic Studies
Seroepidemiology
Serology
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Tropical diseases
University graduates
Viral diseases
Young Adult
Indonesia
East Java Indonesia
China
Japan
ISSN:1932-6203, 1932-6203
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Zusammenfassung:Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic, including Indonesia. However, there are only limited data regarding the precise prevalence of the COVID-19 pandemic in Indonesia. Here, to estimate the magnitude of SARS-CoV-2 infection in East Java, Indonesia, we investigated the prevalence of immunoglobulin G (IgG) antibodies. We enrolled 1,819 individuals from June to December 2020 and observed that the subjects’ overall prevalence of IgG antibody to SARS-CoV-2 was 11.4% (207/1,819). The prevalence of anti-SARS-CoV-2 antibodies differed significantly between the job/occupation groups (P = 0.0001). A greater prevalence of IgG was detected in laboratory technicians (who take samples from suspected cases and deal with polymerase chain reaction [PCR] procedures, 22.2%) compared to medical personnel who see and take direct care of patients with COVID-19 (e.g., physicians and nurses, 6.0%), other staff in medical facilities (2.9%), general population (12.1%) and non-COVID-19 patients (14.6%). The highest prevalence among age groups was in the 40–49-year-olds (14.8%), and the lowest prevalence was in the 20–29-year-olds (7.4%). However, the younger population still showed a higher prevalence than generally reported, suggesting greater exposure to the virus but less susceptibility to the disease. A geographical difference was also observed: a higher prevalence in Surabaya (13.1%) than in Jombang (9.9%). In conclusion, the COVID-19 outbreak among asymptomatic populations was characterized by a high prevalence of infection in East Java, Indonesia.
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0251234