Exposure to Phthalates and Phenols during Pregnancy and Offspring Size at Birth

Background: Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight. Objective: Our aim was to assess the relationships between prenatal exposures to phthalates...

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Bibliographic Details
Published in:Environmental health perspectives Vol. 120; no. 3; pp. 464 - 470
Main Authors: Philippat, Claire, Mortamais, Marion, Chevrier, Cécile, Petit, Claire, Calafat, Antonia M., Ye, Xiaoyun, Silva, Manori J., Brambilla, Christian, Pin, Isabelle, Charles, Marie-Aline, Cordier, Sylvaine, Slama, Rémy
Format: Journal Article
Language:English
Published: Research Triangle Park, NC National Institute of Environmental Health Sciences 01.03.2012
US Department of Health and Human Services
Subjects:
Adult
Biological and medical sciences
Biological markers
Birth
Birth Weight
Bisphenols
Case-Control Studies
Children's Health
Circumferences
Cohort Studies
Ecology, environment
Environment. Living conditions
Environmental Pollutants - toxicity
Environmental Pollutants - urine
Female
Fetus
France - epidemiology
Genitalia, Male - abnormalities
Growth
Head circumference
Health
Health aspects
Humans
Infant, Newborn
Infants
Inverse
Life Sciences
Male
Males
Maternal Exposure
Medical sciences
Metabolites
Middle Aged
Newborns
Offspring
Parabens
Phenols
Phenols - toxicity
Phenols - urine
Phthalates
Phthalic Acids - toxicity
Phthalic Acids - urine
Pregnancy
Pregnancy Outcome - epidemiology
Prenatal Exposure Delayed Effects - chemically induced
Prenatal Exposure Delayed Effects - epidemiology
Public health. Hygiene
Public health. Hygiene-occupational medicine
Statistical analysis
Toxicology
Urine
Young Adult
France
Human
Urine
Prognosis
Size
pregnancy exposure
Biological marker
Exposure
Birth
Pregnancy
Progeny
Fetal development
Phenol
Health and environment
Phenols
birth outcomes
urinary biomarkers
Female
Woman
fetal growth
phthalates
phenols
ISSN:0091-6765, 1552-9924, 1552-9924
Online Access:Get full text
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Summary:Background: Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight. Objective: Our aim was to assess the relationships between prenatal exposures to phthalates and phenols and fetal growth among male newborns. Methods: We conducted a case-control study on male malformations of the genitalia nested in two French mother-child cohorts with recruitment between 2002 and 2006. We measured, in maternal urinary samples collected between 6 and 30 gestational weeks, the concentrations (micrograms per liter) of 9 phenol (n = 191 pregnant women) and 11 phthalate metabolites (n = 287). Weight, length, and head circumference at birth were collected from maternity records. Statistical analyses were corrected for the oversampling of malformation cases. Results: Adjusted birth weight decreased by 77 g [95% confidence interval (CI): –129,–25] and by 49 g (95% CI:–86,–13) in association with a 1-unit increase in In-transformed 2,4-dichlorophenol (DCP) and 2,5-DCP urinary concentrations, respectively. Benzophenone-3 (BP3) In-transformed concentrations were positively associated with weight (26 g; 95% CI:–2 , 54) and head circumference at birth (0.1 cm; 95% CI: 0.0, 0.2). Head circumference increased by 0.3 cm (95% CI: 0.0, 0.7) in association with a 1-unit increase in In-transformed BPA concentration. For phthalate metabolites there was no evidence of monotonie associations with birth weight. Conclusions: Consistent with findings of a previous study, we observed evidence of an inverse association of 2,5-DCP and a positive association of BP3 with male birth weight.
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ISSN:0091-6765
1552-9924
1552-9924
DOI:10.1289/ehp.1103634