The age and genomic integrity of neurons after cortical stroke in humans

In this study, the authors use measures of carbon-14 in neuronal DNA from human stroke patient cortical tissue samples to show that, unlike previous studies done in rodents, they do not find any evidence of increased neurogenesis after an ischemic injury. In addition, DNA damage assays suggest that...

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Veröffentlicht in:	Nature neuroscience Jg. 17; H. 6; S. 801 - 803
Hauptverfasser:	Huttner, Hagen B, Bergmann, Olaf, Salehpour, Mehran, Rácz, Attila, Tatarishvili, Jemal, Lindgren, Emma, Csonka, Tamás, Csiba, László, Hortobágyi, Tibor, Méhes, Gábor, Englund, Elisabet, Solnestam, Beata Werne, Zdunek, Sofia, Scharenberg, Christian, Ström, Lena, Ståhl, Patrik, Sigurgeirsson, Benjamin, Dahl, Andreas, Schwab, Stefan, Possnert, Göran, Bernard, Samuel, Kokaia, Zaal, Lindvall, Olle, Lundeberg, Joakim, Frisén, Jonas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.06.2014 Nature Publishing Group
Schlagworte:	13/31 13/51 45/23 45/91 631/378/368/2431 Aged Aged, 80 and over Analysis Animal Genetics and Genomics Basic Medicine Behavioral Sciences Biological Techniques Biomedicine bomb peak brief-communication cell regeneration Cellular Senescence - physiology Chromosomes cortical stroke DNA DNA Fragmentation DNA repair DNA Repair - physiology Dynamical Systems Female Genetic aspects Genomes Hospitals Humans Ischemia Male Mathematics Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Middle Aged Neocortex - pathology Neocortex - physiology Neurobiology Neurogenesis Neurons Neurons - pathology Neurons - physiology Neurosciences Neurovetenskaper Physiological aspects Stroke Stroke (Disease) Stroke - genetics Stroke - pathology Hungary Sweden Germany
ISSN:	1097-6256, 1546-1726, 1546-1726
Online-Zugang:	Volltext
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