Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

The perpetuation of inflammation is an important pathophysiological contributor to the global medical burden. Chronic inflammation is promoted by non-programmed cell death 1 , 2 ; however, how inflammation is instigated, its cellular and molecular mediators, and its therapeutic value are poorly defi...

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Published in:	Nature (London) Vol. 569; no. 7755; pp. 236 - 240
Main Authors:	Silvestre-Roig, Carlos, Braster, Quinte, Wichapong, Kanin, Lee, Ernest Y., Teulon, Jean Marie, Berrebeh, Nihel, Winter, Janine, Adrover, José M., Santos, Giancarlo Santiago, Froese, Alexander, Lemnitzer, Patricia, Ortega-Gómez, Almudena, Chevre, Raphael, Marschner, Julian, Schumski, Ariane, Winter, Carla, Perez-Olivares, Laura, Pan, Chang, Paulin, Nicole, Schoufour, Tom, Hartwig, Helene, González-Ramos, Silvia, Kamp, Frits, Megens, Remco T. A., Mowen, Kerri A., Gunzer, Matthias, Maegdefessel, Lars, Hackeng, Tilman, Lutgens, Esther, Daemen, Mat, von Blume, Julia, Anders, Hans-Joachim, Nikolaev, Viacheslav O., Pellequer, Jean-Luc, Weber, Christian, Hidalgo, Andrés, Nicolaes, Gerry A. F., Wong, Gerard C. L., Soehnlein, Oliver
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.05.2019 Nature Publishing Group
Subjects:	13/1 13/2 13/21 13/31 13/51 14 14/1 14/19 14/28 14/3 14/69 631/80/82 64/110 64/60 692/420/256/2515 692/699/75/593/2100 82/29 82/51 Animal models Animals Apoptosis Arteries - pathology Arteriosclerosis Artificial intelligence Atherosclerosis Atherosclerosis - pathology Biochemistry Cell adhesion & migration Cell Death Cell Membrane - drug effects Cell Membrane - metabolism Cellular Biology Chemokines Cytotoxicity Destabilization Disease Models, Animal Ejection Female Histone H4 Histones Histones - antagonists & inhibitors Histones - metabolism Humanities and Social Sciences Inflammation Inflammation - metabolism Inflammation - pathology Lesions Letter Leukocytes Leukocytes (neutrophilic) Life Sciences Lysis Mice Mice, Inbred C57BL Mortality multidisciplinary Muscles Myocytes, Smooth Muscle - pathology Neutralization Neutropenia Neutrophils Neutrophils - cytology Observations Open source software Peptides Physiological aspects Plaques Porosity Protein Binding - drug effects Proteins Science Science (multidisciplinary) Smooth muscle Vascular diseases Germany
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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