Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Background Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21 WAF1/Cip1 , showing that its chronic expression...

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Veröffentlicht in:	Genome Biology Jg. 19; H. 1; S. 37
Hauptverfasser:	Galanos, Panagiotis, Pappas, George, Polyzos, Alexander, Kotsinas, Athanassios, Svolaki, Ioanna, Giakoumakis, Nickolaos N., Glytsou, Christina, Pateras, Ioannis S., Swain, Umakanta, Souliotis, Vassilis L., Georgakilas, Alexandros G., Geacintov, Nicholas, Scorrano, Luca, Lukas, Claudia, Lukas, Jiri, Livneh, Zvi, Lygerou, Zoi, Chowdhury, Dipanjan, Sørensen, Claus Storgaard, Bartek, Jiri, Gorgoulis, Vassilis G.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 16.03.2018 Springer Nature B.V BMC
Schlagworte:	Animal Genetics and Genomics Bioinformatics Biomedical and Life Sciences Break-induced replication (BIR) Cancer Cell Line Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - metabolism Deoxyribonucleic acid DNA DNA - biosynthesis DNA damage DNA Repair evolution Evolutionary Biology Experiments fuels genetic instability genome Genomes Genomic Instability Human Genetics Humans Irritable bowel syndrome landscapes Life Sciences Microbial Genetics and Genomics Mutation p21WAF1/Cip1 p53 Protein Plant Genetics and Genomics Post-translation Rad52 Rad52 DNA Repair and Recombination Protein - physiology Rad52 protein Recruitment Replication Senescence Signatures Single nucleotide substitution (SNS) Therapeutic applications therapeutics Transcription transcription (genetics) Translesion DNA synthesis (TLS) Tumor Suppressor Protein p53 - physiology Tumors Single nucleotide substitution (SNS) Rad52 Single strand annealing (SSA) Translesion DNA synthesis (TLS) Break-induced replication (BIR) p21 Genomic instability p21WAF1/Cip1
ISSN:	1474-760X, 1474-7596, 1474-760X
Online-Zugang:	Volltext
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