Histone H4 lysine 16 acetylation regulates cellular lifespan

Cells undergoing developmental processes are characterized by persistent non-genetic alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA methylation and histone post-translational modifications. Sirtuins, a group of conserved NAD+-dependent deacetylases or AD...

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Bibliographic Details
Published in:	Nature (London) Vol. 459; no. 7248; pp. 802 - 807
Main Authors:	Dang, Weiwei, Steffen, Kristan K, Perry, Rocco, Dorsey, Jean A, Johnson, F. Brad, Shilatifard, Ali, Kaeberlein, Matt, Kennedy, Brian K, Berger, Shelley L
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.06.2009 Nature Publishing Group
Subjects:	Acetylation Acetyltransferases Acetyltransferases - metabolism Adenosine diphosphate Ageing, cell death Aging antagonists & inhibitors Apoptosis Binding sites Biological and medical sciences Causes of Cell Division Cell physiology Cells Changes chemistry Chromatin Chromatin - genetics Chromatin - metabolism cytology deficiency Epistasis, Genetic Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Gene Silencing Genetics Health aspects Histone Acetyltransferases Histone Deacetylase Inhibitors Histone Deacetylases Histone Deacetylases - deficiency Histone Deacetylases - metabolism histones Histones - chemistry Histones - genetics Histones - metabolism Humanities and Social Sciences Life span lysine Lysine - metabolism metabolism Methylation Molecular and cellular biology multidisciplinary Mutant Proteins Mutant Proteins - genetics Mutant Proteins - metabolism Mutation Physiological aspects Post-translational modification Proteins Ribosomal DNA Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary) senescence Silent Information Regulator Proteins, Saccharomyces cerevisiae Silent Information Regulator Proteins, Saccharomyces cerevisiae - antagonists & inhibitors Silent Information Regulator Proteins, Saccharomyces cerevisiae - deficiency Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 2 Sirtuins Sirtuins - antagonists & inhibitors Sirtuins - deficiency Sirtuins - metabolism Studies Telomere Telomere - genetics Telomere - metabolism transcription (genetics) Transcription, Genetic Yeasts United States Ascomycota Chromatin Yeast Longevity Fungi Histone H4 Gene silencing Regulation(control) Lysine Cell component Epigenetics Acetylation Saccharomyces cerevisiae
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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