Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages

Activation of cannabinoid receptor 2 (CB2R) ameliorates inflammation, but the underlying mechanism remains unclear. In the present study, we examined whether activation of CB2R could suppress the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome. In peritoneal macropha...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 9; p. e0155076
Main Authors:	Ke, Ping, Shao, Bo-Zong, Xu, Zhe-Qi, Wei, Wei, Han, Bin-Ze, Chen, Xiong-Wen, Su, Ding-Feng, Liu, Chong
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 09.09.2016 Public Library of Science (PLoS)
Subjects:	AMP-Activated Protein Kinases - metabolism Animals Attenuation Autophagy Autophagy - genetics Autophagy - immunology Biology and Life Sciences Cannabinoid CB2 receptors Cell activation Cell death Cell Line Cells, Cultured Colitis Colitis - chemically induced Colitis - genetics Colitis - metabolism Colitis - pathology Colon Dextran Sulfate - adverse effects Experiments House mouse IL-1β Inflammasomes Inflammasomes - metabolism Inflammation Inflammatory bowel disease Infrared imaging systems Interleukin-1beta - metabolism Laboratory animals Leucine Lipopolysaccharides Lipopolysaccharides - immunology Macrophage Activation Macrophages Macrophages - metabolism Macrophages, Peritoneal - metabolism Male Medicine and Health Sciences Mice Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Peritoneum Phagocytosis Pharmacology Pharmacy Polymerase chain reaction Proteins Receptor, Cannabinoid, CB2 - genetics Receptor, Cannabinoid, CB2 - metabolism Ribosomal Protein S6 Kinases, 70-kDa - metabolism Rodents Signal Transduction Signaling siRNA TOR protein TOR Serine-Threonine Kinases - metabolism
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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